DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PAK4 and hpo

DIOPT Version :9

Sequence 1:	NP_001014831.1	Gene:	PAK4 / 10298	HGNCID:	16059	Length:	591	Species:	Homo sapiens
Sequence 2:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster

Alignment Length:	277	Identity:	101/277 - (36%)
Similarity:	156/277 - (56%)	Gaps:	12/277 - (4%)

- Green bases have known domain annotations that are detailed below.

Human   317 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVK----KMDLRKQQRRELLFNEVVIMRDYQHEN 377
            |....|...|:||||.|.|..|..:.|..:||:|    :.||.:      :..|:.||:......
  Fly    38 PEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESDLHE------IIKEISIMQQCDSPY 96

Human   378 VVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR--MNEEQIAAVCLAVLQALSVLHAQGVIHRD 440
            ||..|.||....:||:.||:...|:::||:...:  :.|::||.:....||.|..||.:..||||
  Fly    97 VVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRD 161

Human   441 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMV 505
            ||:.:|||..:|..||:|||...|::..:.:|.:::|||:|||||:|..:.|....|||||||..
  Fly   162 IKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITA 226

Human   506 IEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHP 570
            :||.:|:|||....|::|:.||....||..:...:.|.....|:.:.||::|..||||.|||:|.
  Fly   227 LEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHE 291

Human   571 FLAKAGPPASIVPLMRQ 587
            |:..|...:.:.|::.:
  Fly   292 FIRNAKHRSILKPMLEE 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PAK4	NP_001014831.1	CRIB_PAK_like	10..55	CDD:238526
		Linker	25..320		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..301
		GEF-interaction domain (GID)	298..323		1/5 (20%)
		STKc_PAK4	300..591	CDD:132988	101/277 (36%)
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	98/260 (38%)
		S_TKc	42..293	CDD:214567	97/256 (38%)
		Mst1_SARAH	608..655	CDD:288481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910