Protein Alignment PAK4 and mbt

DIOPT Version :10

• Sequence 1: NP_005875.1
• Gene: PAK4 / 10298
• HGNCID: 16059
• Length: 591
• Species: Homo sapiens
• Sequence 2: NP_523375.2
• Gene: mbt / 32631
• FlyBaseID: FBgn0025743
• Length: 639
• Species: Drosophila melanogaster
• Alignment Length: 666
• Identity: 336/666 - (50%)
• Similarity: 401/666 - (60%)
• Gaps: 107/666 - (16%)

Human     1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSL-----IEESARRPKPLVDPACIT 60
            ||.|:||:..||.|||||||||||||:.|.|:.|||.||.|:     |.:|:.||.|||||:.||
  Fly     1 MFSKKKKKPLISMPSNFEHRVHTGFDKRENKYVGLPLQWASIVGNNQILKSSNRPLPLVDPSEIT 65

Human    61 SIQPGAPKTIVR-------GSKGAKDGALTLLLDEFENMS------------------------- 93
            ..:....|||||       ....:.:.:.|:::.....|:
  Fly    66 PTEILDLKTIVRPHHNNNKADTTSLNSSSTMMMGSMAPMNPMAPGAHPMMSHGPGMMMPPETGGI 130

Human    94 -------VTRSNSLRRDSPPPPAR-ARQENGMPEEPATTARGGPGKAG-SRGRF----------- 138
                   |.||||||..|||...| |.....:|||....|.|.||..| |.|.|
  Fly   131 VLPKTSHVARSNSLRSSSPPRVRRVANVPPSVPEEEGPPAAGTPGVGGASSGGFKPPGAHPSLLY 195

Human   139 -AGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQPAGLASGAKLAAG 202
             :.|:.|.|.:|          |.:.|......|:...:..|.||..:  ||....:....:|:|
  Fly   196 NSQHAHANGATG----------PLAVRTDQTNLQQYRSNLAPPSGGSM--PQQQQTSPVGSVASG 248

Human   203 RPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGL--AIPQSSSSSSRPPTRAR--GAPSPGVLG 263
            ...|                  |....||.|.|..  ..|.|.....:...:|:  |..:...|.
  Fly   249 TRSN------------------HSHTNNGNSGGSYPPMYPTSHQQQQQQQQQAKQGGDQNQNPLH 295

Human   264 PH--------------ASEPQLAPPACTPAAPAVPGPPGPRSPQ-REPQRVSHEQFRAALQLVVD 313
            ||              ||....:....:.||....|..|..:.| ::.||::|||||||||:||.
  Fly   296 PHAHPHPHHHQHLAKSASRASSSSGGASSAAQQASGASGGAAGQPKQDQRLTHEQFRAALQMVVS 360

Human   314 PGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENV 378
            .||||..||:|.||||||||.|||||.:|:|:.|||||||||||||||||||||||||||.|.|:
  Fly   361 AGDPRENLDHFNKIGEGSTGTVCIATDKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYHHPNI 425

Human   379 VEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKS 443
            ||.|:|:||.||||||||:||||||||||||:||:|||||.||...|:||:.||:||||||||||
  Fly   426 VETYSSFLVNDELWVVMEYLEGGALTDIVTHSRMDEEQIATVCKQCLKALAYLHSQGVIHRDIKS 490

Human   444 DSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEM 508
            |||||..||||||||||||||||:|:|:|||||||||||:||:||||||||||||||||||||||
  Fly   491 DSILLAADGRVKLSDFGFCAQVSQELPKRKSLVGTPYWMSPEVISRLPYGPEVDIWSLGIMVIEM 555

Human   509 VDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLA 573
            ||||||:||||||:||:.|||..||.|||.|||||.|:.||||:|||||||||||||||.||||.
  Fly   556 VDGEPPFFNEPPLQAMRRIRDMQPPNLKNAHKVSPRLQSFLDRMLVRDPAQRATAAELLAHPFLR 620

Human   574 KAGPPASIVPLMRQNR 589
            :||||:.:|||||..|
  Fly   621 QAGPPSLLVPLMRNAR 636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAK4	NP_005875.1	CRIB_PAK_like	10..55	CDD:238526	29/49 (59%)
		Linker	25..320		102/371 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..301		58/238 (24%)
		GEF-interaction domain (GID)	298..323		17/24 (71%)
		STKc_PAK4	300..591	CDD:132988	231/290 (80%)
mbt	NP_523375.2	CRIB_PAK_like	9..54	CDD:238526	25/44 (57%)
		STKc_PAK_II	360..620	CDD:270815	209/259 (81%)