Protein Alignment PAK4 and wis4

DIOPT Version :10

• Sequence 1: NP_005875.1
• Gene: PAK4 / 10298
• HGNCID: 16059
• Length: 591
• Species: Homo sapiens
• Sequence 2: NP_593557.1
• Gene: wis4 / 2542873
• PomBaseID: SPAC9G1.02
• Length: 1401
• Species: Schizosaccharomyces pombe
• Alignment Length: 323
• Identity: 102/323 - (31%)
• Similarity: 160/323 - (49%)
• Gaps: 52/323 - (16%)

Human   305 RAALQLVVDPGDPRSYLDNFIKIG-----------------EGSTGIVCIATVRSSGKLVAVKKM 352
            |.|:..|:|....|:  .:|||:.                 .|..|.|.......:|.|:|||::
pombe  1006 RLAIGHVLDDSVFRN--RDFIKLASSFSNITIRWQQGHFVRSGMFGDVYTGVNMETGDLLAVKEI 1068

Human   353 DLRKQQRR------ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR 411
            .|  |..|      :.:.||:.::....|.|||..|...:..:::::.|||.:||:|.|::.|.|
pombe  1069 KL--QDSRTFRSTVDQIHNEMTVLERLNHPNVVTYYGVEVHREKVYIFMEFCQGGSLADLLAHGR 1131

Human   412 MNEEQIAAV-CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVS----KEV-- 469
            :.:|.:..| .:.:|:.|:.:|:|.::|||||..:|||.|.|.:|.||||....||    .||
pombe  1132 IEDENVLKVYVVQLLEGLAYIHSQHILHRDIKPANILLDHRGMIKYSDFGSALYVSPPTDPEVRY 1196

Human   470 ----PRRKSLVGTPYWMAPELISRLPYGP--EVDIWSLGIMVIEMVDGEPPYF---NEPPLKAMK 525
                |..:.|.|||.:||||:|.....|.  .:||||||.:::||:.|..|:.   ||..:  |.
pombe  1197 EDIQPELQHLAGTPMYMAPEIILGTKKGDFGAMDIWSLGCVILEMMTGSTPWSEMDNEWAI--MY 1259

Human   526 MIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAK-------AGPPASI 581
            .:.....|.:....|:|...:.|:::...|||.||..|.:||.||::..       ..|||:|
pombe  1260 HVAAMHTPSIPQNEKISSLARDFIEQCFERDPEQRPRAVDLLTHPWITDFRKKTIITMPPATI 1322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAK4	NP_005875.1	CRIB_PAK_like	10..55	CDD:238526
		Linker	25..320		5/14 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..301
		GEF-interaction domain (GID)	298..323		5/17 (29%)
		STKc_PAK4	300..591	CDD:132988	102/323 (32%)
wis4	NP_593557.1	STKc_MEKK4	1036..1306	CDD:270796	90/273 (33%)