Protein Alignment PAK4 and nak1

DIOPT Version :10

• Sequence 1: NP_005875.1
• Gene: PAK4 / 10298
• HGNCID: 16059
• Length: 591
• Species: Homo sapiens
• Sequence 2: NP_596023.1
• Gene: nak1 / 2539963
• PomBaseID: SPBC17F3.02
• Length: 652
• Species: Schizosaccharomyces pombe
• Alignment Length: 251
• Identity: 90/251 - (35%)
• Similarity: 141/251 - (56%)
• Gaps: 7/251 - (2%)

Human   327 IGEGSTGIVCIATVRSSGKLVAVKKMDL-RKQQRRELLFNEVVIMRDYQH---ENVVEMYNSYLV 387
            :|.||.|.|.......:.:.||:|.::| ..:.....:..||.::.:.:.   ||:::.:.||||
pombe    16 VGRGSYGAVYRGICNLTKETVAIKILNLDTDEDEVSDIQKEVAVLSELKQSDVENIIKYHGSYLV 80

Human   388 GDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDG 452
            |..||::|::..||::..::....::|..|:.:....||||..:|..|:||||||:.:||::..|
pombe    81 GTNLWIIMDYCHGGSVRTLMEAGPISEPCISLILRETLQALKFIHHAGIIHRDIKAANILVSMSG 145

Human   453 RVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI-SRLPYGPEVDIWSLGIMVIEMVDGEPPYF 516
            .|||.|||..|:::....:|.:.:|||||||||:| ....|....|||||||...|:..|.||:.
pombe   146 NVKLCDFGVAAELNINRRKRITFIGTPYWMAPEVIRDGQEYNVMADIWSLGITAYEIATGSPPHA 210

Human   517 NEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 572
            .|.|.:|:.:|....||||..  ..|..||.|:...|...|.:|..::||||..|:
pombe   211 KEDPFRAVYLIAHTAPPRLNG--NFSALLKEFIASCLQDVPQRRLDSSELLKSKFI 264

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAK4	NP_005875.1	CRIB_PAK_like	10..55	CDD:238526
		Linker	25..320
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..301
		GEF-interaction domain (GID)	298..323
		STKc_PAK4	300..591	CDD:132988	90/251 (36%)
nak1	NP_596023.1	Protein Kinases, catalytic domain	8..282	CDD:473864	90/251 (36%)