Protein Alignment PAK4 and pak-2

DIOPT Version :10

• Sequence 1: NP_005875.1
• Gene: PAK4 / 10298
• HGNCID: 16059
• Length: 591
• Species: Homo sapiens
• Sequence 2: NP_505809.2
• Gene: pak-2 / 179527
• WormBaseID: WBGene00006443
• Length: 522
• Species: Caenorhabditis elegans
• Alignment Length: 602
• Identity: 253/602 - (42%)
• Similarity: 322/602 - (53%)
• Gaps: 131/602 - (21%)

Human     4 KRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLI--EESARRPKPLVDPACITSIQPGA 66
            ::.|:.|||.|||||||:|.|||.....:||||:|||:|:  ..|..||||:|||:|||.:....
 Worm     9 RKVKKSEISTPSNFEHRIHAGFDARSGTYTGLPKQWQALLGPPRSISRPKPMVDPSCITPVDVAE 73

Human    67 PKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPATTARGGPGK 131
            .||::||.                      |:|.|.:||.|       .||...|..:.    .:
 Worm    74 LKTVIRGP----------------------SSSFRYNSPLP-------FGMTNSPMPSV----AR 105

Human   132 AGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQPAGLASG 196
            :.|....|..|.....|..|....|...|.|.|
 Worm   106 SNSLRISATASPVVNVSSARHSFRPTLPPVSQR-------------------------------- 138

Human   197 AKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGV 261
                 |.||                        |.||...|.:     .:.:||.    :.:.||
 Worm   139 -----GYPF------------------------NDPSYAPLPL-----RNQKPPM----STTFGV 165

Human   262 LGPH-------------ASEPQLAPPACTPAAPAVPGPPGPRSPQREP---QRVSHEQFRAALQL 310
            ..||             .:.|||.|.:          |..|::.:::|   :.||.|:||.||:.
 Worm   166 EKPHQYQQIITIVAPSRTTTPQLQPKS----------PSTPQAMRQQPKCTEGVSDEEFRNALKF 220

Human   311 VVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQH 375
            |||..||||.|.::.:|||||||:|..|...|:.::||||:|:||||||||||||||.|:|.|||
 Worm   221 VVDGTDPRSDLTDYKQIGEGSTGVVEAAYKISTKQIVAVKRMNLRKQQRRELLFNEVSILRQYQH 285

Human   376 ENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 440
            .|:|..::|:||.|||||||||:|||:||||||.|||.|.|||.:...||.||..|||:.|||||
 Worm   286 PNIVRFFSSHLVDDELWVVMEFMEGGSLTDIVTATRMTEPQIATISRQVLGALDFLHARKVIHRD 350

Human   441 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMV 505
            ||||||||..||.|||:|||||.|:|:|||||:||||||||.|.|:|:|.||....||||.|||:
 Worm   351 IKSDSILLKRDGTVKLTDFGFCGQLSEEVPRRRSLVGTPYWTAAEVIAREPYDTRADIWSFGIML 415

Human   506 IEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHP 570
            ||||:||||:||:.|.:|||.|||....|.....|||..|...|...:|:|..:|..|.:||:||
 Worm   416 IEMVEGEPPFFNDQPFQAMKRIRDEHEARFSRHAKVSVELSELLSHCIVKDVNKRWPAKDLLRHP 480

Human   571 FLAKAGPPASIVPLMRQ 587
            |.|||...:||.||:.|
 Worm   481 FFAKAQHSSSIAPLLLQ 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAK4	NP_005875.1	CRIB_PAK_like	10..55	CDD:238526	27/46 (59%)
		Linker	25..320		76/312 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..301		39/221 (18%)
		GEF-interaction domain (GID)	298..323		15/24 (63%)
		STKc_PAK4	300..591	CDD:132988	176/288 (61%)
pak-2	NP_505809.2	CRIB_PAK_like	14..60	CDD:238526	26/45 (58%)
		Protein Kinases, catalytic domain	223..483	CDD:473864	160/259 (62%)