Protein Alignment PAK4 and pak4

DIOPT Version :10

• Sequence 1: NP_005875.1
• Gene: PAK4 / 10298
• HGNCID: 16059
• Length: 591
• Species: Homo sapiens
• Sequence 2: XP_012823244.1
• Gene: pak4 / 100036644
• XenbaseID: XB-GENE-1013749
• Length: 665
• Species: Xenopus tropicalis
• Alignment Length: 661
• Identity: 444/661 - (67%)
• Similarity: 480/661 - (72%)
• Gaps: 81/661 - (12%)

Human     1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQPG 65
            ||||:|||:|||||.||||||||||||.|||||||||||||||||||:||||||||:.||:|...
 Frog    16 MFGKKKKRIEISAPLNFEHRVHTGFDQQEQKFTGLPRQWQSLIEESAKRPKPLVDPSYITTINHV 80

Human    66 APKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSP---PPPARARQENGMPE-------- 119
            ..||||||||.:.||:|..|||||:.||:.|||||||:||   |...|..|||||.|
 Frog    81 PQKTIVRGSKMSLDGSLAWLLDEFDAMSICRSNSLRRESPPCHPREDRFHQENGMSEVRVRQQRE 145

Human   120 ---------------------------------EPATTARGG--------PGKAGSRGRFAGHSE 143
                                             ||:...|..        |.|.|:|....|...
 Frog   146 DGQRGSERNRSEHSRRERQREEHKAVPQQPRGQEPSNKHRPPPPDYPKDIPEKRGTRSHEKGDGR 210

Human   144 AGGGSGDR-----------RRAGPEKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQPAGLASGA 197
            ......||           |..|.|||||||...:.|..:|.|||||||||.:.||..:......
 Frog   211 REYPVNDRGYSEPVERVVKREKGEEKRPKSSYTSAEGSPQSPRDKRPLSGPSIRTPGSSSTEGVV 275

Human   198 K-LAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIPQS-SSSSSRP-----PTRARG 255
            | ...||.|||||||:|| |||||   ||.| |:..|...|....: |.|||||     ..:...
 Frog   276 KQTQTGRAFNTYPRAETD-PSRGA---PHQV-PDSHSTVPLDSKSTVSKSSSRPQQGQVKPKLPD 335

Human   256 APSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSY 320
            .|.|..|.||:|:|||:.|..|      ..|..|||||||||||||||||||||:||||||||:|
 Frog   336 KPHPTQLVPHSSDPQLSHPVQT------QHPAQPRSPQREPQRVSHEQFRAALQMVVDPGDPRTY 394

Human   321 LDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 385
            |||||||||||||||||||::||||||||||||||||||||||||||||||||||||||||||||
 Frog   395 LDNFIKIGEGSTGIVCIATIKSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSY 459

Human   386 LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTH 450
            ||||||||:||||||||||||||||||||||||.||::||:||||||||||||||||||||||||
 Frog   460 LVGDELWVIMEFLEGGALTDIVTHTRMNEEQIATVCVSVLKALSVLHAQGVIHRDIKSDSILLTH 524

Human   451 DGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPY 515
            |||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   525 DGRVKLSDFGFCAQVNKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPY 589

Human   516 FNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPAS 580
            ||||||||||||||||||:|||..||||.|||||||||||||:|||:|.||||||||.|||||:.
 Frog   590 FNEPPLKAMKMIRDNLPPKLKNAQKVSPLLKGFLDRLLVRDPSQRASANELLKHPFLGKAGPPSC 654

Human   581 IVPLMRQNRTR 591
            |||||||||.|
 Frog   655 IVPLMRQNRLR 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAK4	NP_005875.1	CRIB_PAK_like	10..55	CDD:238526	41/44 (93%)
		Linker	25..320		170/364 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..301		101/275 (37%)
		GEF-interaction domain (GID)	298..323		22/24 (92%)
		STKc_PAK4	300..591	CDD:132988	270/290 (93%)
pak4	XP_012823244.1	CRIB_PAK_like	24..70	CDD:238526	41/45 (91%)
		Protein Kinases, catalytic domain	374..665	CDD:473864	270/290 (93%)