Protein Alignment APC2 and Apc2

DIOPT Version :9

• Sequence 1: XP_006722671.2
• Gene: APC2 / 10297
• HGNCID: 24036
• Length: 2404
• Species: Homo sapiens
• Sequence 2: NP_001334699.1
• Gene: Apc2 / 42871
• FlyBaseID: FBgn0026598
• Length: 1067
• Species: Drosophila melanogaster
• Alignment Length: 1469
• Identity: 393/1469 - (26%)
• Similarity: 561/1469 - (38%)
• Gaps: 502/1469 - (34%)

Human   385 ATRDQEDTARTLLAMSSSPESCVAMRRSGCLPLLLQILHGTEAAAGGRAGAPGAPGAKDARMRAN 449
            |||  .:..|..|.:|.:||:|.|:|.|.|:.||:||||..:            .|...|:..|:
  Fly     8 ATR--LELTRNFLELSRNPETCTALRSSDCIQLLVQILHAND------------EGLSTAKKYAS 58

Human   450 AALHNIVFSQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDGGPEGGGAGSAPIPIEPQICQ 514
            .||||||.:.|::...::|:::|.:|:||..||......||:      ||.|.:......|  ..
  Fly    59 QALHNIVHNNPEEKERQREVKMLRLLDQILDYCNFLHTQLQS------GGEAIADDEDRHP--LA 115

Human   515 ATCAVMKLSFDEEYRRAMNELGGLQAVAELLQVDYEMH--KMTRDPLNLALRRYAGMTLTNLTFG 577
            |...:||.|||||:|:.|.|||.|:|:..|:.:|:.:|  ...|:..| |||.|..|.|||||||
  Fly   116 AMKLLMKASFDEEHRQTMCELGALKAIPNLVHLDHAVHGPAAGREQCN-ALRSYGLMALTNLTFG 179

Human   578 D--VANKATLCARRGCMEAIVAQLASDSEELHQVVSSILRNLSWRADINSKKVLREAGSVTALVQ 640
            |  |.||:.||.:|..||.::|||.:..:||.||::.:|||||||||.:.|.:..|.|:||:|.:
  Fly   180 DENVHNKSYLCGQRQFMEVVIAQLNTAPDELLQVLAGVLRNLSWRADKHMKTIFNELGTVTSLAR 244

Human   641 CVLRATKESTLKSVLSALWNLSAHSTENKAAICQVDGALGFLVSTLTYKCQSNSLAIIESGGGIL 705
            ..::...|:|||::||||||||||.:.|||..|.|||||.|||..|:|:..|.:|.|||:.||||
  Fly   245 AAMQNKNENTLKAILSALWNLSAHCSTNKAEFCAVDGALAFLVGMLSYEGPSKTLKIIENAGGIL 309

Human   706 RNVSSLVATREDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSARSARDQELLWDLGAV 770
            |||||.:|..|.|||:||.:|||..|||.|.|.|||:|||:||||||||||...||:.|.|..|:
  Fly   310 RNVSSHIAVCEPYRQILRRYNCLAILLQQLKSESLTVVSNSCGTLWNLSARCPEDQQYLIDHNAI 374

Human   771 GMLRNLVHSKHKMIAMGSAAALRNLLAHRPAKHQAAATAVSPGSCVPSLYVRKQRALEAELDARH 835
            .:||.|:.||:.|||.|||:||:||:..|
  Fly   375 PLLRALISSKNSMIAEGSASALKNLVNFR------------------------------------ 403

Human   836 LAQALEHLEKQGPPAAEAATKKPLPPLRHLDGLAQDYASDSGCFDDDDAPSSLAAAAATGEPASP 900
                              ||::.:|            ..|.|
  Fly   404 ------------------ATQELMP------------NGDGG----------------------- 415

Human   901 AALSLFLGSPFLQGQALARTPPTRRGGKEAEKDTSGEAAVAAKAKAKLALAVARIDQLVEDISAL 965
               ||.|......|..|.|.                                         .|:|
  Fly   416 ---SLPLDKEAGHGGTLPRR-----------------------------------------FSSL 436

Human   966 HTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEGGRREAGSRAHPLLRLKAAHASLSNDSLNS 1030
            ..||:.:.||....|...:......:.|.                             |.:|:.|
  Fly   437 RLSSNPTGSLKKVRPSTVSTTGFLNRKCE-----------------------------SRESIYS 472

Human  1031 G-SASDGYCPREHMLPCPLAALASRREDP-----RCGQPRPS-----RLDLDLP----------- 1073
            | |.|..|..:......|...:....|.|     :..:.:|:     .:|||.|
  Fly   473 GKSDSTKYSTKSEGAKNPFEIVTPTEEQPIDYSMKYMEHKPNSSKTFEIDLDQPTDFSARYKERR 537

Human  1074 GCQAEPPAREATSADARVRTIKLSPTYQHVPLLEGASRAGAEPLAGPG-ISPGARKQAWLPADHL 1137
            ..|...|..::.:.:.|.:.::|:           .|.:..|....|| ::..|.||     ...
  Fly   538 SAQTAQPELKSETNEIRSKELQLT-----------KSSSATELRNSPGLVAVSAAKQ-----KIA 586

Human  1138 SKVPEKLAAAPLSVASKALQKLAAQEG-PLSLSRCSSLSSLSSAGRPGPSEGGDLDDSDSSLEGL 1201
            ::...:.|..|::.         .:|| |.|.||..||:||:                    |..
  Fly   587 TETETETAERPINY---------CEEGTPGSFSRFDSLNSLT--------------------EKP 622

Human  1202 EEAGPSEAELDSTWRAPGATS-LPVAIPAPRRNRGRGLGVEDATPSSSSENYVQETPLVLSRCSS 1265
            |:..|.        :.|..|: |||             .|:..||.:...  ..||||:.||.||
  Fly   623 EKCMPP--------KTPTKTAVLPV-------------HVDGNTPQNIDS--ALETPLMFSRRSS 664

Human  1266 VSSL-GSFESPSIA--SSIPSEPCSGQGSGTISPSELPDSPGQTMPPSRSKTPPLAPAPQGPPEA 1327
            :.|| |..|:.:..  .|:.|| .|...||.||||||||||.|:|             ||.|...
  Fly   665 MDSLVGDDETVACEDNGSVISE-YSRMQSGVISPSELPDSPTQSM-------------PQSPRRD 715

Human  1328 TQFSLQWESYVKRFLDIADCRERCRLPSELDAGSVRFTVEKPDENFSCASSLSALALHEHYVQQD 1392
            .:.|.|      ..||..:.:.......:|:    ||.||.....||||:|||.|::     ..|
  Fly   716 RKVSTQ------NNLDTPEQKPSTVFEDKLN----RFHVEHTPAAFSCATSLSNLSM-----MDD 765

Human  1393 VELRLLPSACPERGGGAGGAGLHFAGHRRREEGPAP--------TGSRPRGAADQELELLRECLG 1449
            .....:..   :||....|            .|.||        |....:..::.:|.:|
  Fly   766 SNANAIRG---QRGNDING------------NGDAPRSYCTEDTTAVLSKAPSNSDLSIL----- 810

Human  1450 AAVPARLRKVASALVPGRRA--------LP--------------VPVYMLVPAPAPAQEDDSCTD 1492
             ::|..|....:..||..||        :|              :|.|:.|       .|:....
  Fly   811 -SIPNDLNANEAQPVPAPRADVTGMDTRMPAEDAISKMRCGGNALPSYLPV-------SDEMSKY 867

Human  1493 SAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSR 1557
            ..|.:|..||..:.||..|:
  Fly   868 YVEDSPCTFSVISGLSHLTV--------------------------------------------- 887

Human  1558 GAGKNRAG--LELPLGRPPSAPADKDGSKPGRTRGDG----------ALQSLCLTTPTEEAVYCF 1610
              |..:||  |:||:.....|.|.|...:....:||.          :|.||.:
  Fly   888 --GSAKAGPVLKLPMRTAEEAQAPKLPPRRSAVQGDAEPRLPPKKSDSLSSLSM----------- 939

Human  1611 YGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAPPPARTQPSLIADETP 1675
               |||::        .:..:.||.....|.:|.|                 |.|..||
  Fly   940 ---DSDDD--------CNLLSQAIAAGSCRPQPSG-----------------ASTSSSL------ 970

Human  1676 PCYSLSSSASSL-SEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALP 1739
                .::|.|:| .|...|:....|  |.:|..:.|    ...|.......::.|.::||
  Fly   971 ----ANASTSTLCRENGQSKKQVEH--GDKPNYSSD----DSLDDDDDDARSKSLFEQCI----- 1020

Human  1740 RRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDR 1778
                 :||:.:.........|.|  |.|   :|.:..||
  Fly  1021 -----LSGMHKSNDALESEGEPP--GQR---QEISARDR 1049

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147381
Domainoid	1	1.000	191	1.000	Domainoid score	I3246
eggNOG	1	0.900	-	-		E1_KOG2122
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002986
OrthoInspector	1	1.000	-	-		mtm8653
orthoMCL	1	0.900	-	-		OOG6_105450
Panther	1	1.100	-	-	O	PTHR12607
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2401
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.770