Protein Alignment APC2 and Apc2

DIOPT Version :10

• Sequence 1: XP_054175471.1
• Gene: APC2 / 10297
• HGNCID: 24036
• Length: 2404
• Species: Homo sapiens
• Sequence 2: NP_001359169.1
• Gene: Apc2 / 23805
• MGIID: 1346052
• Length: 2317
• Species: Mus musculus
• Alignment Length: 2347
• Identity: 1892/2347 - (80%)
• Similarity: 1998/2347 - (85%)
• Gaps: 52/2347 - (2%)

Human    71 ISGGA---RGAAQREEAPDPGAPPAQLHTLQELKMASSVAPYEQLVRQVEALKAENSHLRQELRD 132
            :|||.   ||:..|.:.      |.::..||||||.||:|.|||||||||||||||:||||||||
Mouse    10 VSGGMWGHRGSRPRTQT------PGRIVALQELKMTSSMASYEQLVRQVEALKAENTHLRQELRD 68

Human   133 NSSHLSKLETETSGMKEVLKHLQGKLEQEARVLVSSGQTEVLEQLKALQMDITSLYNLKFQPPTL 197
            |||||||||||||||||||||||||||||||||||||||||||||||||.||:|||||||..|.|
Mouse    69 NSSHLSKLETETSGMKEVLKHLQGKLEQEARVLVSSGQTEVLEQLKALQTDISSLYNLKFHAPAL 133

Human   198 GPEPAARTPEGSPVHGSGPSKDSFGELSRATIRLLEELDRERCFLLNEIEKEEKEKLWYYSQLQG 262
            |||||||||||||||||||||||||||||||||||||||:||||||:||||||||||||||||||
Mouse   134 GPEPAARTPEGSPVHGSGPSKDSFGELSRATIRLLEELDQERCFLLSEIEKEEKEKLWYYSQLQG 198

Human   263 LSKRLDELPHVETQFSMQMDLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDKEL 327
            |||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   199 LSKRLDELPHVDTQFSMQMDLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDKEL 263

Human   328 LEAQDRVQQTEPQALLAVKSVPVDEDPETEVPTHPEDGTPQPGNSKVEVVFWLLSMLATRDQEDT 392
            |||||||||||||||||||.|.|:|:.|.||||||||||||||||||||||||||||||||||||
Mouse   264 LEAQDRVQQTEPQALLAVKPVAVEEEQEAEVPTHPEDGTPQPGNSKVEVVFWLLSMLATRDQEDT 328

Human   393 ARTLLAMSSSPESCVAMRRSGCLPLLLQILHGTEAAAGGRAGAPGAPGAKDARMRANAALHNIVF 457
            |||||||||||||||||||||||||||||||||||.:.||||.||||||||||||||||||||||
Mouse   329 ARTLLAMSSSPESCVAMRRSGCLPLLLQILHGTEAGSVGRAGIPGAPGAKDARMRANAALHNIVF 393

Human   458 SQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDGGPEGGGAGSAPIPIEPQICQATCAVMKL 522
            ||||||||||||||||||||||||||||||||||||.|.| .|.|..|:||||||||||||||||
Mouse   394 SQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDSGTE-SGTGDTPVPIEPQICQATCAVMKL 457

Human   523 SFDEEYRRAMNELGGLQAVAELLQVDYEMHKMTRDPLNLALRRYAGMTLTNLTFGDVANKATLCA 587
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   458 SFDEEYRRAMNELGGLQAVAELLQVDYEMHKMTRDPLNLALRRYAGMTLTNLTFGDVANKATLCA 522

Human   588 RRGCMEAIVAQLASDSEELHQVVSSILRNLSWRADINSKKVLREAGSVTALVQCVLRATKESTLK 652
            ||||||||||||.|:|||||||||||||||||||||||||||||.||:|||::|||||:||||||
Mouse   523 RRGCMEAIVAQLGSESEELHQVVSSILRNLSWRADINSKKVLREVGSMTALMECVLRASKESTLK 587

Human   653 SVLSALWNLSAHSTENKAAICQVDGALGFLVSTLTYKCQSNSLAIIESGGGILRNVSSLVATRED 717
            ||||||||||||||||||||||||||||||||||||:||.||||:||||||||||||||:|||||
Mouse   588 SVLSALWNLSAHSTENKAAICQVDGALGFLVSTLTYRCQGNSLAVIESGGGILRNVSSLIATRED 652

Human   718 YRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSARSARDQELLWDLGAVGMLRNLVHSKHK 782
            ||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||
Mouse   653 YRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSARSPRDQELLWDLGAVGMLRNLVHSKHK 717

Human   783 MIAMGSAAALRNLLAHRPAKHQAAATAVSPGSCVPSLYVRKQRALEAELDARHLAQALEHLEKQG 847
            ||||||||||||||||||||:||||.|||||:||||||||||||||||||.|||..||.|||||.
Mouse   718 MIAMGSAAALRNLLAHRPAKYQAAAMAVSPGTCVPSLYVRKQRALEAELDTRHLVHALGHLEKQS 782

Human   848 PPAAEAATKKPLPPLRHLDGLAQDYASDSGCFDDDDAPSSLAAAAATGEPASPAALSLFLGSPFL 912
            .|.||..:|||||||||||||.|||||||||||||||| ||||||.|.||||||.:|:|||.|||
Mouse   783 LPEAETTSKKPLPPLRHLDGLVQDYASDSGCFDDDDAP-SLAAAATTAEPASPAVMSMFLGGPFL 846

Human   913 QGQALARTPPTRRGGKEAEKDTSGEAAVAAKAKAKLALAVARIDQLVEDISALHTSSDDSFSLSS 977
            ||||||||||.|:||.||||:..|||||||||||||||||||||:||||||||||||||||||||
Mouse   847 QGQALARTPPARQGGLEAEKEAGGEAAVAAKAKAKLALAVARIDRLVEDISALHTSSDDSFSLSS 911

Human   978 GDPGQEAPREGRAQSCSPCRGPEGGRREAGSRAHPLLRLKAAHASLSNDSLNSGSASDGYCPREH 1042
            |||||||||||||||||||||.|||||||||||||||||||||.|||||||||||.|||||.|||
Mouse   912 GDPGQEAPREGRAQSCSPCRGTEGGRREAGSRAHPLLRLKAAHTSLSNDSLNSGSTSDGYCTREH 976

Human  1043 MLPCPLAALASRREDPRCGQPRPSRLDLDLPGCQAEPPAREATSADARVRTIKLSPTYQHVPLLE 1107
            |.||||||||..|:||..||.||||||||||. :||.|||:..:.|||||||||||||||||||:
Mouse   977 MTPCPLAALAEHRDDPVRGQTRPSRLDLDLPS-RAELPARDTAATDARVRTIKLSPTYQHVPLLD 1040

Human  1108 GASRAGAEPLAGPGISPGARKQAWLPADHLSKVPEKLAAAPLSVASKALQKLAAQEGPLSLSRCS 1172
            ||:.||..||.|||.|||||||||:|||.||||||||.|:||.:|||.||||.||:||:||||||
Mouse  1041 GAAGAGVRPLVGPGTSPGARKQAWIPADSLSKVPEKLVASPLPIASKVLQKLVAQDGPMSLSRCS 1105

Human  1173 SLSSLSSAGRPGPSEGGDLDDSDSSLEGLEEAGPSEAELDSTWRAPGATSLPVAIPAPRRNRGRG 1237
            |||||||.|...||:..:| ||||||||||||||.||||...|||.|:|||||:||||:|.|.||
Mouse  1106 SLSSLSSTGHAVPSQAENL-DSDSSLEGLEEAGPGEAELGRAWRASGSTSLPVSIPAPQRGRSRG 1169

Human  1238 LGVEDATPSSSSENYVQETPLVLSRCSSVSSLGSFESPSIASSIPSEPCSGQGSGTISPSELPDS 1302
            ||||||||||||||.||||||||||||||||||||||.||||||||:||||.||||:||||||||
Mouse  1170 LGVEDATPSSSSENCVQETPLVLSRCSSVSSLGSFESRSIASSIPSDPCSGLGSGTVSPSELPDS 1234

Human  1303 PGQTMPPSRSKTPPLAPAPQGPPEATQFSLQWESYVKRFLDIADCRERCRLPSELDAGSVRFTVE 1367
            |||||||||||||   |||.|.||.:|||||||||||||||||||||||:.||||||||||||||
Mouse  1235 PGQTMPPSRSKTP---PAPPGQPETSQFSLQWESYVKRFLDIADCRERCQPPSELDAGSVRFTVE 1296

Human  1368 KPDENFSCASSLSALALHEHYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRRREE------GP 1426
            |||||||||||||||||||.||||||||||.|.|||||..|.|       |||||:|      ||
Mouse  1297 KPDENFSCASSLSALALHELYVQQDVELRLRPPACPERAVGGG-------GHRRRDEAASRLDGP 1354

Human  1427 APTGSRPRGAADQELELLRECLGAAVPARLRKVASALVPGRRALPVPVYMLVPAPAPAQEDDSCT 1491
            ||.|||.|.|.|:|||.||||||||:||||||||||||||||:|||||||||  ||||:.|||.|
Mouse  1355 APAGSRARSATDKELEALRECLGAAMPARLRKVASALVPGRRSLPVPVYMLV--PAPARGDDSGT 1417

Human  1492 DSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSARQAMGHRHKAGGAGRSAEQS 1556
            ||||||||||||||||||||||||.||:|.||..||:||||...|||...||.||.|||:|.|.:
Mouse  1418 DSAEGTPVNFSSAASLSDETLQGPSRDKPAGPGDRQKPTGRAAPARQTRSHRPKAAGAGKSTEHT 1482

Human  1557 RGAGKNRAGLELPLGRPPSAPADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPA 1621
            ||..:|||||||||.||.||.:::|.|...|||||||||||||||||||||||||  ||||||||
Mouse  1483 RGPCRNRAGLELPLSRPQSARSNRDSSCQTRTRGDGALQSLCLTTPTEEAVYCFY--DSDEEPPA 1545

Human  1622 AAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAPPPARTQPSLIADETPPCYSLSSSASS 1686
            .||.|  ||.||||||..||:|.||||  .||:||..|..|.|.||.||.|||||||||:|||||
Mouse  1546 TAPPP--RRASAIPRALKREKPAGRKE--TPSRAAQPATLPVRAQPRLIVDETPPCYSLTSSASS 1606

Human  1687 LSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRR 1751
            |||||..|.||.|.||        |..|..:||||||||.|||||||||.|:||||..|.|.|||
Mouse  1607 LSEPEAPEQPANHARG--------PEQGSKQDSSPSPRAEEELLQRCISLAMPRRRTQVPGSRRR 1663

Human  1752 KPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAA-ATREASSES 1815
            ||||.|.|.||.|.:::..||.||||.|||||||||:|||||||||||||||||| |:.||||||
Mouse  1664 KPRALRSDIRPTEITQKCQEEVAGSDPASDLDSVEWQAIQEGANSIVTWLHQAAAKASLEASSES 1728

Human  1816 DSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQK 1880
            ||:||.|||:|.||||||.|.||||:...|.|.|.||||||..|.|.:||||.|.||||.:||||
Mouse  1729 DSLLSLVSGVSAGSTLQPSKLRKGRKPAAEAGGAWRPEKRGTTSTKINGSPRLPNGPEKAKGTQK 1793

Human  1881 TTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLH 1945
            ...|...:||||||||...||.|.|.||..||..||:|.......||....|.|||.||||||||
Mouse  1794 MMAGESTMLRGRTVIYSAGPASRTQSKGISGPCTTPKKTGTSGTTQPETVTKAPSPEQQRSRSLH 1858

Human  1946 RPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPGASPVP 2010
            ||.|.||||.|..|||||||||||||||||||||||||||||||:.|..|...|.|||||.|.||
Mouse  1859 RPGKISELAALRHPPRSATPPARLAKTPSSSSSQTSPASQPLPRRSPLATPTGGPLPGPGGSLVP 1923

Human  2011 KTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVR 2075
            |:|||.|||||||||:||||||||||||||.||||||..||||.|||||.|..|||||.||||||
Mouse  1924 KSPARALLAKQHKTQKSPVRIPFMQRPARRVPPPLARPSPEPGSRGRAGAEGTPGARGSRLGLVR 1988

Human  2076 VASALSSGSESSDRSGFRRQLTFIKESPG-LRRRRSELSSAESAASAPQGASPRRGRPALPAVFL 2139
            :|||.|||||||||||||||||||||||| |||||||||||:|.||..|.|||||||||||||||
Mouse  1989 MASARSSGSESSDRSGFRRQLTFIKESPGLLRRRRSELSSADSTASTSQAASPRRGRPALPAVFL 2053

Human  2140 CSSRCEELRAAPRQGPAP-ARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYASL 2203
            |||||:|||.:|||   | |.||.|.|:|....|..|||:|||||||||||...|||||||||||
Mouse  2054 CSSRCDELRVSPRQ---PLAAQRSPQAKPGLAPRAPRRTSSESPSRLPVRASPGRPETVKRYASL 2115

Human  2204 PHISVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATAL 2268
            |||||:||.|.||......|:|.||.||||.|||||||.||||||||:|||||||||||||||||
Mouse  2116 PHISVSRRSDSAVSVPTTQANATRRGSDGEARPLPRVAPPGTTWRRIKDEDVPHILRSTLPATAL 2180

Human  2269 PLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAGGQLSLLGSDVDG 2333
            |||.|:|||:|||.|.|||||||||||:||..|||||||||||:|:||.|||.|.::..||||||
Mouse  2181 PLRVSSPEDSPAGTPQRKTSDAVVQTEDVATSKTNSSTSPSLESRDPPQAPASGPVAPQGSDVDG 2245

Human  2334 PSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSARVPPFNYVPSPMVVAA-TTDSAAEKAPAT 2397
            |.|.|.|.||||.||||...:.|||.||||||||:|||||||||||||..|. .:|||.||||.:
Mouse  2246 PVLTKPPASAPFPHEGLSAVIAGFPTSRHGSPSRAARVPPFNYVPSPMAAATMASDSAVEKAPVS 2310

Human  2398 ASATLLE 2404
            :.|:|||
Mouse  2311 SPASLLE 2317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
APC2	XP_054175471.1	APC_N_CC	107..158	CDD:435517	48/50 (96%)
		Suppressor_APC	225..306	CDD:463275	77/80 (96%)
		APC_rep	458..532	CDD:465870	65/73 (89%)
		armadillo repeat	531..574	CDD:293788	42/42 (100%)
		armadillo repeat	582..619	CDD:293788	34/36 (94%)
		armadillo repeat	628..661	CDD:293788	27/32 (84%)
		armadillo repeat	669..710	CDD:293788	37/40 (93%)
		Arm	716..755	CDD:425727	38/38 (100%)
		armadillo repeat	719..753	CDD:293788	33/33 (100%)
		armadillo repeat	761..797	CDD:293788	35/35 (100%)
		Arm_APC_u3	798..1045	CDD:435476	214/246 (87%)
		APC_r	1361..1382	CDD:461781	20/20 (100%)
		PHA03247	<1436..2012	CDD:223021	402/576 (70%)
		APC_basic	1887..2214	CDD:428690	245/328 (75%)
		PHA03247	2103..>2328	CDD:223021	168/226 (74%)
Apc2	NP_001359169.1	APC_N_CC	43..94	CDD:435517	48/50 (96%)
		Suppressor_APC	161..242	CDD:463275	77/80 (96%)
		APC_rep	394..467	CDD:465870	65/73 (89%)
		armadillo repeat	466..509	CDD:293788	42/42 (100%)
		armadillo repeat	517..554	CDD:293788	34/36 (94%)
		armadillo repeat	563..596	CDD:293788	27/32 (84%)
		armadillo repeat	604..645	CDD:293788	37/40 (93%)
		Arm	651..690	CDD:425727	38/38 (100%)
		armadillo repeat	654..688	CDD:293788	33/33 (100%)
		Arm	692..732	CDD:425727	38/39 (97%)
		armadillo repeat	696..732	CDD:293788	35/35 (100%)
		Arm_APC_u3	733..979	CDD:435476	214/246 (87%)
		APC_r	1178..1201	CDD:461781	21/22 (95%)
		APC_r	1290..1311	CDD:461781	20/20 (100%)
		PHA03247	<1328..1665	CDD:223021	248/359 (69%)
		APC_r	1413..1435	CDD:461781	20/21 (95%)
		PHA03247	<1548..1987	CDD:223021	309/450 (69%)
		APC_basic	1800..2132	CDD:428690	248/334 (74%)
		PTZ00449	<2042..2239	CDD:185628	148/199 (74%)