Protein Alignment BCKDK and Pdk

DIOPT Version :10

• Sequence 1: NP_005872.2
• Gene: BCKDK / 10295
• HGNCID: 16902
• Length: 412
• Species: Homo sapiens
• Sequence 2: NP_001097240.1
• Gene: Pdk / 35970
• FlyBaseID: FBgn0017558
• Length: 422
• Species: Drosophila melanogaster
• Alignment Length: 335
• Identity: 100/335 - (29%)
• Similarity: 164/335 - (48%)
• Gaps: 41/335 - (12%)

Human    89 KSARYLQQELPVRIAHRIKGFRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQY-- 151
            ||..:|::|||||:|:.:|....||..:....::..|...|:::|:.:..:...:...|..|.
  Fly    49 KSYIFLRKELPVRLANIMKEIALLPDNLLHTRSVSEVSSWYVKSFEDVLVYEKAEPTHDNLQKFV 113

Human   152 --CQLVRQLLDDHKDVVTLLAEGLRESRKH------IEDEKLVRYFLDKTLTSRLGIRMLATHHL 208
              ..|:|   :.|.|||..:|:|:.|.:::      ...|..::||||:...||:.||||...|.
  Fly   114 ADLDLIR---NRHNDVVQTMAQGVIEMKENEGGQVDAPTESSIQYFLDRLYMSRISIRMLINQHT 175

Human   209 ALHEDKPD----FVGIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGH-------VAARF 262
            .|....|.    .:|.:........::....:.||.||:..|..:|.:.|..|       :..|.
  Fly   176 LLFGGNPHAGGRHIGCLDPACDLSDVVRDAYENARFLCDQYYLTSPALEIQQHSSEPGDNLPIRT 240

Human   263 PFIPMPLDYILPELLKNAMRATMESH-LDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLD 326
            .::|..|.|:|.||.||:|||.:|.| .|....:|.:.:.|.....|:.::|||:||||.....|
  Fly   241 VYVPSHLYYMLFELFKNSMRAVVEHHGHDNNDTLPPLKVAICKGKEDICVKISDQGGGIPRSQTD 305

Human   327 RVMDYHFTTAEASTQDPRISPLFGHLDMHSGAQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQG 391
            ::..|.::||...::.          |:|    :.|:.|:|:|||.||.||.|..|.:.|.|.:|
  Fly   306 QLFKYMYSTAPQPSKS----------DLH----TVPLAGYGYGLPISRLYARYFHGDIVLLSCEG 356

Human   392 IGTD--VYLR 399
            .|||  :||:
  Fly   357 FGTDAIIYLK 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BCKDK	NP_005872.2	BCDHK_Adom3	69..222	CDD:463093	41/146 (28%)
		HATPase_PDK-like	226..401	CDD:340406	59/184 (32%)
Pdk	NP_001097240.1	BCDHK_Adom3	32..193	CDD:463093	41/146 (28%)
		HATPase_PDK-like	197..366	CDD:340406	58/182 (32%)