DRSC/TRiP Functional Genomics Resources

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Protein Alignment TRAIP and nopo

DIOPT Version :10

Sequence 1:NP_005870.2 Gene:TRAIP / 10293 HGNCID:30764 Length:469 Species:Homo sapiens
Sequence 2:NP_611305.1 Gene:nopo / 37083 FlyBaseID:FBgn0034314 Length:435 Species:Drosophila melanogaster


Alignment Length:452 Identity:117/452 - (25%)
Similarity:200/452 - (44%) Gaps:97/452 - (21%)


- Green bases have known domain annotations that are detailed below.


Human     7 CTICSDFFDHSRDVAAIHCGHTFHLQCLIQWFETAPSRTCPQCRIQVGKRTIINKLFFDLAQEEE 71
            |.||::.|..:.:|.|..|||.||..||.||.:.  |:||||||.:...|.|. :::|:||..:.
  Fly     6 CVICAELFGQADEVFATVCGHMFHHNCLNQWLDR--SKTCPQCRNKCTTRNIF-RVYFNLANLDV 67

Human    72 NVLDAEFLKNELDNVRAQLSQKDKEK-RDSQVIIDTLRDTLEERNATVVSLQQALGKAEMLCSTL 135
            :.:|...|:.:|||....:...:||: :|.|.|.| |::|.::...|:..|:|.:.|.:.|.|:.
  Fly    68 SHIDVGSLQEQLDNAMLSMKMVEKERNKDEQQIRD-LKETQKKCLKTIAGLEQKVQKKDFLISSY 131

Human   136 KKQMKYLEQQQDETKQAQEEARRLRSKMKTMEQIELLLQSQRPEVEEMIRDMGVGQSAVEQLAVY 200
            .:|:..|:.........::|.:.|:|::::||.|..:|.:...:.:.::::    ::....||.:
  Fly   132 VEQIGVLKSDAHVVDGLRKENKTLKSQIQSMEGISAILAAGSADADRLLKN----EADPHVLANW 192

Human   201 CVSLKKEYENLK----EARKASGEVADKLRKDLFSSRSKLQTVYSELD------QAKL---ELKS 252
            ..:||:|....:    |.|.....|.:.|||::...| ||:...|.|:      |.||   |.|:
  Fly   193 VSTLKRELRQCESKKTELRNVVKVVQNDLRKEIELKR-KLEERVSHLESDLYQAQEKLQAFENKT 256

Human   253 AQKDLQSA----DKEIMSLKKKLTMLQETLNLPPVASETVDRLVLESPAPVEVNLKLRRPSFRDD 313
            |..|..:|    :..|::||::    :....:.|...|.:.| :.||.:|. :|:|         
  Fly   257 AYLDSPNASCGLNSNILALKRE----ERRTTISPTVKENIKR-IEESTSPY-LNIK--------- 306

Human   314 IDLNATFDVDTPPARPSSSQHGYYE------KLCLEKSH-SPIQDVPKKICKGPRKESQLSLGGQ 371
                             ||..|...      .:.|.||. |||:.|.               ||.
  Fly   307 -----------------SSSVGLAHLLNTKGNIGLAKSKISPIKGVG---------------GGV 339

Human   372 SCAG----EPDEELVGAFPIFVRNAILGQKQPKRPRSESSCSKDVVRTG----FDGLGGRTK 425
            |...    :...:|...:.||        |:|:.....||.|.....||    ::|:||..|
  Fly   340 SMTSGTIRKTSSDLSEKYSIF--------KKPRLLLGSSSSSALTATTGSNFVYNGMGGSEK 393

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TRAIPNP_005870.2 RING-H2_TRAIP 6..50 CDD:438143 20/42 (48%)
EnvC 65..>278 CDD:443969 57/230 (25%)
Interaction with CYLD. /evidence=ECO:0000269|PubMed:14676304 211..469 57/247 (23%)
PIP-box. /evidence=ECO:0000269|PubMed:26711499 460..469
nopoNP_611305.1 RING-H2_TRAIP 5..47 CDD:438143 20/42 (48%)
SMC_N <75..>255 CDD:481474 47/185 (25%)
Blue background indicates that the domain is not in the aligned region.

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