DRSC/TRiP Functional Genomics Resources

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Protein Alignment SPEG and CaMKI

DIOPT Version :9

Sequence 1:XP_011508781.1 Gene:SPEG / 10290 HGNCID:16901 Length:3277 Species:Homo sapiens
Sequence 2:NP_524622.1 Gene:CaMKI / 43792 FlyBaseID:FBgn0016126 Length:405 Species:Drosophila melanogaster


Alignment Length:436 Identity:118/436 - (27%)
Similarity:186/436 - (42%) Gaps:90/436 - (20%)


- Green bases have known domain annotations that are detailed below.


Human  1607 LSDFYDIHQEIGRGAFSYLRRIVERSS-GLEFAAKFIPSQA-KPK-ASARREARLL--------- 1659
            :.:.|::|..:|.||||.:|....:.| |..||.|.|..:| |.| .|...|.|:|         
  Fly    27 IEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKGKEESLENEIRVLRRFSANHFD 91

Human  1660 ------ARLQHDCVLYFHEAFERRRGLVIVTELCT-EELLERIARKPTVCESEIRAYMRQVLEGI 1717
                  .||.|..::...|.:|.:..:.:|.||.| .||.:||..|.:..|.:....:||:||.:
  Fly    92 GKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASHLIRQILEAV 156

Human  1718 HYLHQSHVLHLDVKPENLLVWDGAAGEQQVRICDFGNAQELTPG-EPQYCQYGTPEFVAPEIVNQ 1781
            .|:|:..|:|.|:||||||.: ....:.::.|.|||.::....| ....|  |||.:||||::.|
  Fly   157 DYMHEQGVVHRDLKPENLLYY-SPDDDSKIMISDFGLSKMEDSGIMATAC--GTPGYVAPEVLAQ 218

Human  1782 SPVSGVTDIWPVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGF---LI 1843
            .|.....|:|.:||::::.|.|..||..|||......|...:..|:...:..:|..|:.|   |:
  Fly   219 KPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESAKHFIKNLM 283

Human  1844 KVLVQDRLRPTAEETLEHPWFKTQAKGAEVS--------TDHLKLFLSRRRWQRSQISYKCHLVL 1900
            .|.|:.|.  |.::.|.|.|.    .|.|.|        ::.||...::.||::   :|....|:
  Fly   284 CVTVEKRY--TCKQALGHAWI----SGNEASSRNIHGTVSEQLKKNFAKSRWKQ---AYYAATVI 339

Human  1901 RPIPELLRAPPERVWVTMPRRPPPSGGLSSSSDSEEEELEELPSVPRPLQPEFSGSRVSLTDIPT 1965
            |.:..:                    .|:|:|::                 .|..|..|     .
  Fly   340 RQMQRM--------------------ALNSNSNA-----------------NFDSSNSS-----N 362

Human  1966 EDEALGTPETGAATPMDWQEQGRAPSQDQEAPSPEALPSPGQEPAA 2011
            :|....|..|||     |.....:..|..::.:.|...|.|...||
  Fly   363 QDSTTPTAATGA-----WTSNVLSSQQSVQSHAQEMNKSGGSTNAA 403

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SPEGXP_011508781.1 I-set 43..125 CDD:254352
Ig 45..125 CDD:299845
I-set 732..821 CDD:254352
Ig 755..822 CDD:299845
SPEG_u2 822..878 CDD:293256
I-set 879..969 CDD:254352
IGc2 892..959 CDD:197706
I-set 983..1068 CDD:254352
Ig 995..1065 CDD:143165
I-set 1074..1163 CDD:254352
Ig 1091..1163 CDD:299845
I-set 1198..1287 CDD:254352
Ig 1215..1287 CDD:299845
I-set 1400..1490 CDD:254352
I-set 1495..1584 CDD:254352
Ig 1512..1581 CDD:143165
STKc_SPEG_rpt1 1608..1864 CDD:271010 89/278 (32%)
S_TKc 1611..1864 CDD:214567 89/275 (32%)
I-set 2594..2684 CDD:254352
Ig 2615..2684 CDD:299845
STKc_SPEG_rpt2 2972..3228 CDD:271013
S_TKc 2976..3228 CDD:214567
CaMKINP_524622.1 STKc_CaMKI 27..301 CDD:270985 89/278 (32%)
S_TKc 31..302 CDD:214567 89/275 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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