DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPEG and CG10126

DIOPT Version :9

Sequence 1:	XP_011508781.1	Gene:	SPEG / 10290	HGNCID:	16901	Length:	3277	Species:	Homo sapiens
Sequence 2:	NP_788664.2	Gene:	CG10126 / 41579	FlyBaseID:	FBgn0038088	Length:	227	Species:	Drosophila melanogaster

Alignment Length:	173	Identity:	36/173 - (20%)
Similarity:	66/173 - (38%)	Gaps:	41/173 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   387 LSEASGRLSALGRSPRLV-RAGSRILDKLQFF------------EERRRSLERSDSPPA------ 432
            ||..:..:..|||:.|.: ..||:.|::.:|.            ||.::.....|...:
  Fly    52 LSRGATGILGLGRAFRAMDDDGSKALNEEEFITGIRDTGLDVSEEEIKQMFATFDEDGSGSINMT 116

Human   433 ----PLRPWVPLRKARSLEQ-----PKSERGAPWGTPGASQEELRAPGSVAERRRLFQQKAASLD 488
                .|||.:|..:...::|     .:.|.|.      .:.::|:...||.|..: :|....|.|
  Fly   117 EFLLKLRPPMPQSRLNIIDQAFNKMDRDEDGV------ITIQDLKNVYSVKEHPK-YQSGEKSED 174

Human   489 ERTRQRSPASDLELRFAQELGRIRRSTSREELVRSHESLRATL 531
            |      ..:|....|....|.:....:|||.|..:.::.|::
  Fly   175 E------ILTDFLHNFEGGRGNLDGKITREEFVNYYATISASI 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPEG	XP_011508781.1	I-set	43..125	CDD:254352
		Ig	45..125	CDD:299845
		I-set	732..821	CDD:254352
		Ig	755..822	CDD:299845
		SPEG_u2	822..878	CDD:293256
		I-set	879..969	CDD:254352
		IGc2	892..959	CDD:197706
		I-set	983..1068	CDD:254352
		Ig	995..1065	CDD:143165
		I-set	1074..1163	CDD:254352
		Ig	1091..1163	CDD:299845
		I-set	1198..1287	CDD:254352
		Ig	1215..1287	CDD:299845
		I-set	1400..1490	CDD:254352
		I-set	1495..1584	CDD:254352
		Ig	1512..1581	CDD:143165
		STKc_SPEG_rpt1	1608..1864	CDD:271010
		S_TKc	1611..1864	CDD:214567
		I-set	2594..2684	CDD:254352
		Ig	2615..2684	CDD:299845
		STKc_SPEG_rpt2	2972..3228	CDD:271013
		S_TKc	2976..3228	CDD:214567
CG10126	NP_788664.2	EF-hand_7	62..119	CDD:290234	11/56 (20%)
		EFh	64..119	CDD:238008	9/54 (17%)
		EFh	97..154	CDD:238008	9/62 (15%)
		EF-hand_7	98..158	CDD:290234	9/65 (14%)
		EF-hand_7	134..204	CDD:290234	18/82 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900