DRSC/TRiP Functional Genomics Resources

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Protein Alignment CDKN2A and mlt-2

DIOPT Version :10

Sequence 1:XP_011515977.1 Gene:CDKN2A / 1029 HGNCID:1787 Length:184 Species:Homo sapiens
Sequence 2:NP_492036.2 Gene:mlt-2 / 172459 WormBaseID:WBGene00007252 Length:668 Species:Caenorhabditis elegans


Alignment Length:147 Identity:41/147 - (27%)
Similarity:60/147 - (40%) Gaps:30/147 - (20%)


- Green bases have known domain annotations that are detailed below.


Human     1 MEPAAGSSME----PSADWLATAAARGRVEEVRALL-------------EAGALPNAPNSYGRRP 48
            |..||...::    |..::| .||..|.::::..||             :..||..|        
 Worm     1 MSGAAADGIDDRDIPKQEFL-DAAFNGDIDKIDGLLRDKKVHIDSVDDDQVTALHIA-------- 56

Human    49 IQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRL 113
               ..||:.::...||.:||..:..:...:| ..|.|||||.|..|..|.:.||..:...|.|..
 Worm    57 ---AAMGNNKLVVRLLDYGANIHAVNHLGMT-AYHYAAREGKLAVLDTLMQRGASKNQTTALGVT 117

Human   114 PVDLAEELGHRDVARYL 130
            .:.||...||.||.|.|
 Worm   118 ALTLACAGGHADVVRRL 134

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CDKN2AXP_011515977.1 ANKYR <16..148 CDD:440430 37/128 (29%)
ANK repeat 16..42 CDD:293786 9/38 (24%)
ANK repeat 44..74 CDD:293786 6/29 (21%)
ANK repeat 76..108 CDD:293786 12/31 (39%)
mlt-2NP_492036.2 ANKYR 4..241 CDD:440430 40/144 (28%)
ANK repeat 51..79 CDD:293786 9/38 (24%)
ANK repeat 81..112 CDD:293786 12/31 (39%)
ANK repeat 144..179 CDD:293786
ANK repeat 181..214 CDD:293786
PHA03095 201..>351 CDD:222980
ANK repeat 273..305 CDD:293786
ANK repeat 307..338 CDD:293786
Blue background indicates that the domain is not in the aligned region.

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