DRSC/TRiP Functional Genomics Resources

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Protein Alignment CWC27 and Moca-cyp

DIOPT Version :10

Sequence 1:NP_005860.2 Gene:CWC27 / 10283 HGNCID:10664 Length:472 Species:Homo sapiens
Sequence 2:NP_733246.1 Gene:Moca-cyp / 43374 FlyBaseID:FBgn0039581 Length:970 Species:Drosophila melanogaster


Alignment Length:564 Identity:152/564 - (26%)
Similarity:216/564 - (38%) Gaps:158/564 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    22 GDIDIELWSKEAPKACRNFIQLCL-----------EAYYDNTIFHRVVPGFIVQGGD-PTGTGSG 74
            |.|..||::..|||...||..||.           :..|...||||||..|:||.|| ..|.|:|
  Fly    27 GRIVFELFNDVAPKTAENFRALCTGEKGFGLITGKKLQYKGVIFHRVVKDFMVQAGDFSAGNGTG 91

Human    75 GESIYGAPFKDEFHSRLRFNRRGLVAMANAGSHDNGSQFFFTLGRADELNNKHTIFGKV-TGDTV 138
            ||||||..|:||...: :.:|..|::|||.|.:.||||||.|...|..|:|.|.:||:| :|..:
  Fly    92 GESIYGGTFEDESFEK-KHDRPFLLSMANRGKNTNGSQFFITTQPAPHLDNIHVVFGQVISGQEL 155

Human   139 YNMLRLSEVDIDDDERPHNPHKIKSCEVLFNPFDDIIPREIKRLKKEKPEEEVKKLKPKGTKNFS 203
              :.:|..:.:|.:.||.....|.:|            .|:.|..|.|.|   ||.|.:.|..  
  Fly   156 --VRQLEGLPVDRNSRPLQDAAIANC------------GELVRQTKAKKE---KKHKRRSTAT-- 201

Human   204 LLSFGEEAEEEEEEVN-RVSQSMKGKSKSSHDLLKDDPHLSSVPVVESEKGDAP-DLVDDGEDES 266
                 |::..||.|.. :|.:..|.|.:|.    ||....|.....|:.:|:.. |.....:||.
  Fly   202 -----EDSNSEESEAEAKVVRKAKKKKRSR----KDTKSQSDSEDNETSRGNGKHDQTPQDDDED 257

Human   267 AEHDEY--------IDGDE------KNLMRERIAKKL------------------KKDTSAN--- 296
            .|..|.        ||.:|      |.|||...:|.|                  .:|.|.|   
  Fly   258 REEGELHPLVTITKIDPNEIPEVSNKFLMRAERSKSLDREERGARGQDRDRGKDQDRDRSRNNFG 322

Human   297 ---------------VKSAGEGEVEKKSVSRSEELR----KEARQLKRELLAAKQKKVENAAKQA 342
                           ||..|.......|.|||....    |.|:  ||.:..:..:::|..:|..
  Fly   323 WSKKQAPPTSRSGRIVKGRGVFRFRTPSRSRSRSTTPPHWKHAQ--KRTIKLSDLERIEEESKMR 385

Human   343 E----------KRSEEE--------------------EAPPDGAVAEYRREKQKYEALR---KQQ 374
            |          ||..||                    :..||....|: :.|.|..|.|   |::
  Fly   386 EEEMKRREHERKRRHEEATKNPKQSFFELSHASTYGGKITPDRFSPEH-KAKSKDTADRGKAKER 449

Human   375 SKKGTSREDQTLALLNQFKSKLTQAIAETPENDIPETEVEDDEGWMSHVLQFEDKSRKVKDASMQ 439
            .|.|...:.:.:..:.:.||....|:....:.   |:|||.:          :::..|||..|.|
  Fly   450 EKAGEKDKARDVTPVKRRKSMDMNALDYEQQT---ESEVESE----------DEEQLKVKPPSKQ 501

Human   440 D--------SDTFEIYDPRNPVN---KRRREESKKLMREKKERR 472
            |        .|.....|.|.|..   |.:|..|:...|:...||
  Fly   502 DIRVEPSTSKDRNAKRDERKPTEEKAKPKRSRSRSPRRQSPARR 545

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CWC27NP_005860.2 cyclophilin_CeCYP16-like 8..178 CDD:238906 62/168 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 206..386 58/268 (22%)
DUF5401 <302..>472 CDD:375164 46/217 (21%)
CWC27_CTD 376..428 CDD:412084 9/51 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 398..472 19/84 (23%)
Moca-cypNP_733246.1 cyclophilin 13..180 CDD:469651 62/167 (37%)
PRK12678 612..>804 CDD:237171
Blue background indicates that the domain is not in the aligned region.

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