Protein Alignment CWC27 and CG5808

DIOPT Version :10

• Sequence 1: NP_005860.2
• Gene: CWC27 / 10283
• HGNCID: 10664
• Length: 472
• Species: Homo sapiens
• Sequence 2: NP_651291.1
• Gene: CG5808 / 42957
• FlyBaseID: FBgn0027617
• Length: 653
• Species: Drosophila melanogaster
• Alignment Length: 556
• Identity: 126/556 - (22%)
• Similarity: 217/556 - (39%)
• Gaps: 163/556 - (29%)

Human    15 VLLKTTAGDIDIELWSKEAPKACRNFIQLCLEAYYDNTIFHRVVPGFIVQGGDPTGTGSGGESIY 79
            |:::||.||:.::|:..|.|.||.||::||...||:..:||.|..|||.|.|||:|.|.||.||:
  Fly     3 VVIETTMGDLTVDLFISERPIACLNFLKLCRLKYYNFNLFHTVQQGFIAQTGDPSGAGDGGSSIW 67

Human    80 GAP-------FKDEFHSRLRFNRRGLVAMANAGSHDNGSQFFFTLG-RADELNNKHTIFGKVT-G 135
            |..       |:.||..::..:..|::::.:||.:..|||||.||| ....|:..|.:.|:|. |
  Fly    68 GVVEGPQKRFFEAEFLPKINHSSAGMLSLVSAGKNLVGSQFFLTLGENLTSLDGNHCVIGEVVEG 132

Human   136 DTVYNMLRLSEVDIDDDERPHNPHKIKSCEVLFNPFDDIIPREIKRLKKEKPEEEVKKLKPKGTK 200
            ..|  :.:|::..:||..||:...:|....||.:||.:  ||.: :.....|....::||.
  Fly   133 HEV--LRKLNDAIVDDSFRPYQDIRITHTVVLEDPFPN--PRGL-QAPSRSPSPSAERLKN---- 188

Human   201 NFSLLSFGEEAEEEE---------EEVNRVSQSMKGKSKSS-HDLLKDDPHLSSVP--------- 246
                   |..|.:|:         ||:..:....:.|:::: .:::.|.|.....|
  Fly   189 -------GRIAADEDIDDTDGMTAEEMQEMLAEREAKARATILEIVGDLPDADMAPPENVLFVCK 246

Human   247 ------------------------VVESEK-GDAPD--LVDDGEDESAE---------------- 268
                                    |:...| ||:..  .|:..:.:|.|
  Fly   247 LNPVTTDDDLEIIFSSFGVLKGCEVIRDRKTGDSLQYAFVEFEDQKSCEAAYFKMDNVLIDDRRI 311

Human   269 HDEY---------------IDGDEKNLMRERIAKKLKKDTSANVKSAGEGEVE-KKSVSRSEELR 317
            |.::               |:||.:.|    ....|:.|......:.|....| .|..:|:|:.|
  Fly   312 HVDFSQSVSKVTWRGKGRGIEGDYRKL----DFNNLRDDKDHRKPNNGRSRTEDHKERNRTEDFR 372

Human   318 KEARQLKRELLAAKQKKVENAAKQAEKRSEEEEAPPDGAVAEYRREKQKYEALRKQQSKKGTSRE 382
                               |....||:|...|:          |.::|....:||...::..|:|
  Fly   373 -------------------NRMSSAERRKAREQ----------RHQEQSERDVRKNLQRRTRSKE 408

Human   383 DQTLALLNQFKSKLTQAIAETPENDIPETEVEDDEGWMSHVLQFEDKSRKVKDAS------MQDS 441
            ....::....||: .:::.|....:....               |.:|.:.:||:      .:|.
  Fly   409 KDEKSVYRSKKSQ-NESVRENSNRERNRN---------------EKRSSRSRDATHRRYSRSRDR 457

Human   442 DTFEIYDPRNPVNKRRR-----EESKKLMREKKERR 472
            :......||:.:.:|.|     |..:...||:.|||
  Fly   458 EERRPSRPRDQLGRRSRSRDQKERRRSRPREQNERR 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CWC27	NP_005860.2	cyclophilin_CeCYP16-like	8..178	CDD:238906	64/171 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..386		40/257 (16%)
		DUF5401	<302..>472	CDD:375164	32/181 (18%)
		CWC27_CTD	376..428	CDD:412084	5/51 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	398..472		14/84 (17%)
CG5808	NP_651291.1	cyclophilin_RRM	4..169	CDD:238902	62/168 (37%)
		RRM_PPIL4	237..319	CDD:409681	9/81 (11%)
		PRK12678	344..>510	CDD:237171	36/195 (18%)
		U2AF_lg	467..>572	CDD:273727	8/27 (30%)