DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NET1 and trio

DIOPT Version :9

Sequence 1:	NP_001040625.1	Gene:	NET1 / 10276	HGNCID:	14592	Length:	596	Species:	Homo sapiens
Sequence 2:	NP_651960.2	Gene:	trio / 43974	FlyBaseID:	FBgn0024277	Length:	2263	Species:	Drosophila melanogaster

Alignment Length:	480	Identity:	103/480 - (21%)
Similarity:	188/480 - (39%)	Gaps:	94/480 - (19%)

- Green bases have known domain annotations that are detailed below.

Human   114 RRFGQTIQSFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEA 178
            :..|.:.|...|..|..|..|:......|.....||..||...::.::...::|     .||:|.
  Fly  1227 KSLGMSQQQLLLGSDGNSSISSSSGDRHSDPTLEAKLNSSNKENKEINEEKRKS-----ARRKEF 1286

Human   179 IY-EMSRGEQDLIEDLKLARKAYHDPM-----LKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIG 237
            |. |:.:.|:..:.||....|.:.:..     :..:::.:|::  |||::......|:.:..|
  Fly  1287 IMAELMQTERAYVNDLATCIKCFLEEFRAGKSVPSALIGQEDV--IFGNIKEIHHFHQKIFLR-- 1347

Human   238 EATKPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKL 302
            |..|.:...|.:||..|:|..:.:.|..||.|:..:..||.|  ......:.|||.||      :
  Fly  1348 ELEKYETMPEDVGHCFVTWASKFDMYVHYCKNKPTSNNLLVQ--HGGSFFEELQRRLE------V 1404

Human   303 D--LWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESE---- 361
            |  |.::|..|..|:.||.||||::|....:.|.:::         :|:...:|:.|..::
  Fly  1405 DHPLPAYLIKPVQRITKYQLLLKDLLSCCEESHGEIK---------EGLEVMLNVPKKANDAMHL 1460

Human   362 -----CQYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNER 421
                 |...:|||..:..:......:..:::        :.|.:..:|||:..|:..:.|..:..
  Fly  1461 SLLENCDVSVDKLGEVVLQDAFQAWDTKQII--------RKGRERRVFLFELYLLFAKEVKESNV 1517

Human   422 HSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSH---TLQA 483
            ..|| ::..:...::.:.:..:||......:.|.                  ||..|.   .|:|
  Fly  1518 VKYQ-FKSKLMTTDMGITEHIEGDETKFAVWTGR------------------SPMLSDCRIVLKA 1563

Human   484 NDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEGNHPSARKLTAQRRASTVSSVTQVE 548
            ..:..||.|...:|..:.....:|:...|...|..|.  ..:..|:|.|..|
  Fly  1564 TSLETKQIWVKKLREVMQETCFSGTSLTLPKSPAKHS--GSSQRSSRDLDEQ------------- 1613

Human   549 VDENAY-RC-----GSGMQMAEDSK 567
            :.||.: ||     |||.....|:|
  Fly  1614 LTENDHDRCSLASFGSGNTTDSDNK 1638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NET1	NP_001040625.1	Necessary for nuclear localization. /evidence=ECO:0000250	1..74
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		Nuclear localization signal. /evidence=ECO:0000250	12..19
		Nuclear localization signal. /evidence=ECO:0000250	66..72
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..146		4/18 (22%)
		RhoGEF	178..354	CDD:214619	45/183 (25%)
		PH_Net1	368..502	CDD:270044	22/136 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	562..596		2/6 (33%)
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544
		RhoGEF	1287..1456	CDD:279015	47/189 (25%)
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	24/148 (16%)
		PH	1495..1580	CDD:278594	19/103 (18%)
		SH3_Kalirin_1	1643..1707	CDD:212786
		RhoGEF	1945..2122	CDD:279015
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940