DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NET1 and Exn

DIOPT Version :9

Sequence 1:	NP_001040625.1	Gene:	NET1 / 10276	HGNCID:	14592	Length:	596	Species:	Homo sapiens
Sequence 2:	NP_001097630.2	Gene:	Exn / 39900	FlyBaseID:	FBgn0261547	Length:	2029	Species:	Drosophila melanogaster

Alignment Length:	589	Identity:	128/589 - (21%)
Similarity:	223/589 - (37%)	Gaps:	155/589 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    19 RASGLSTEGATGPSADTSGSE--LDGRCSLRRGSSFTFLTPGPNWDFTLKRKRREKDDDVVSLSS 81
            :.||:|...::|.|..::|:|  |....|....|.|
  Fly  1453 QTSGISVASSSGSSGVSTGNEAGLGDELSSEPHSLF----------------------------- 1488

Human    82 LDLKEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQSFTLRGDHRSPASAQKFSSRSTVPT 146
                  ||:   ||.::.|.|.|.|..|:..........:...|:...:.....:...:...:..
  Fly  1489 ------SNE---PLYQMYSAAKLESITRDLEAHGSSDGYEEIGLQAKAKPEPLVKPRPTALQLVE 1544

Human   147 PAKRRSSALWSEMLDI---TMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAY--HDPMLK 206
            |....|..||||:.::   .:..:||:||...|||.:|:...|...::.|.|.|:.:  |:..|.
  Fly  1545 PKNGPSRTLWSEIPEVIHSCILPTLTSRERSLQEAKFEIITSEASYLKSLNLLRRHFMNHNAFLD 1609

Human   207 LSIMSEEELTHIFGDLDSYI-PLH---EDLLTRIGEATKPDGTVEQIGHILVSWLPR-------- 259
            .|::|.::...:|    ||| |:|   |.|||.: ||...|       :|::..|.|
  Fly  1610 SSVLSAKDRKALF----SYIVPVHECSERLLTEL-EACWQD-------NIMLLGLSRCIYEIAER 1662

Human   260 -LNAYRGYCSNQ-LAAKAL--LDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPL 320
             .:.|..:|.:| ...:.|  |.:.|:....|..|:|...||....|:|.|||.:|..|:.:.||
  Fly  1663 HFHVYVAFCEHQGRMDRTLRRLKESKESLAFQQHLERLEASPSCCGLNLHSFLMLPMQRITRLPL 1727

Human   321 LLKEIL-KHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDK----LEYLDEKQR--- 377
            |:..:. |.:|....:.:..:..:.::|.|:...|......|..:.:::    ||:....:.
  Fly  1728 LIDAVFSKESPLNREEYESWKLTLALVQKVVGQCNEAANRWEQAFELERIARQLEFPSHVRALAI 1792

Human   378 ----DPRIEAS-KVLLCHGEL----------RSKSGHKL-----YIFLFQDILVLTRPVTRNERH 422
                .||..|. :.|:..|||          :...|.:|     |.|||.|:|:|.:   |....
  Fly  1793 APVGVPRAGAKPRFLVKRGELTHLLWRGEDAKLTFGKRLTKISIYAFLFSDLLLLCK---RRGES 1854

Human   423 SYQVY----RQPI------PVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQ 477
            .:.|:    |..:      .:.:|..:||:|                :..||:..:...:....:
  Fly  1855 CFSVFDYCPRSMLTLAAGDSLPQLPTKDLKD----------------QAGKNLILMTLLENCDRK 1903

Human   478 S--HTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLPE-LHE--EC---------EGNHPS 528
            :  ..|....|..:|:|...:|           |||.:...| |:|  :|         |.:.|.
  Fly  1904 TVELVLSCPSVSDQQRWLQAMR-----------PPEAETPGEKLYESWDCPQVVAKHSYESDEPD 1957

Human   529 ARKL 532
            ..:|
  Fly  1958 VLQL 1961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NET1	NP_001040625.1	Necessary for nuclear localization. /evidence=ECO:0000250	1..74		11/56 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		8/26 (31%)
		Nuclear localization signal. /evidence=ECO:0000250	12..19		128/589 (22%)
		Nuclear localization signal. /evidence=ECO:0000250	66..72		0/5 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..146		0/18 (0%)
		RhoGEF	178..354	CDD:214619	51/194 (26%)
		PH_Net1	368..502	CDD:270044	32/172 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	562..596
Exn	NP_001097630.2	RhoGEF	1581..1763	CDD:279015	50/193 (26%)
		PH_ephexin	1805..1931	CDD:269929	30/155 (19%)
		SH3_ephexin1_like	1944..1998	CDD:212727	3/18 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840