Protein Alignment STAG1 and psc3

DIOPT Version :10

• Sequence 1: NP_005853.2
• Gene: STAG1 / 10274
• HGNCID: 11354
• Length: 1258
• Species: Homo sapiens
• Sequence 2: NP_001343016.1
• Gene: psc3 / 2542387
• PomBaseID: SPAC17H9.20
• Length: 962
• Species: Schizosaccharomyces pombe
• Alignment Length: 1040
• Identity: 213/1040 - (20%)
• Similarity: 408/1040 - (39%)
• Gaps: 206/1040 - (19%)

Human     1 MITSELPVLQDSTNETTAHSDAGSELEETEVKGKRKRGRPGRPPSTNKKPRKSPGEKSRIEAGIR 65
            |::.....:..|:| :::..::..:.|:| :..|::..||      |.|             |:
pombe    22 MLSQSFDPMSSSSN-SSSEENSDDDYEKT-ISSKKRHPRP------NSK-------------GV- 64

Human    66 GAGRGRANGHPQQNGEGEPV-TLFEVVKLGKSAMQSVVDDWIESYKQDRDIALLDLINFFIQCSG 129
            ...|.|.|...:::.:.|.. .||..:...|.....:...|...|.:|...||.:||||.::|.|
pombe    65 NVKRSRRNAIVEEDPQEEIFNNLFAFLLDQKVDTMDIAVSWFADYAKDNQSALANLINFILKCCG 129

Human   130 CRGTVRIEMFRNMQNAEIIRKMTEEFDE--DSGDYPLTMPGPQWKKFRSNFCEFIGVLIRQCQY- 191
            |...:.:...::..:|.......:...|  .:.||||.....:::.||......:...:.|...
pombe   130 CNRAINVFDVQDQDSASATLSQIQLSVERTSTRDYPLNSKNLKFRNFRKRLTGLLSNFVSQLSIR 194

Human   192 SIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNLSIHQDNTQRQYEAE-- 254
            :.:|:..:.:.::|.:..:|.|.:|..|||:|:..:.:||.|...:..|........:|.|.|
pombe   195 NYLYNSTVFEDIMSWVVAMSSSTMRPIRHTATVFCLNIMTFLCEKSKELLNEHAIATKQLEKEEK 259

Human   255 RNKMIGKRANERLELLLQKRKELQENQDEIENMMNSIFKGIFVHRYRDAIAEIRAICIEEIGVWM 319
            |:::...|.||    |.....|:.:.||.:...:|..|..:|||||||...:||..|::|:|||:
pombe   260 RSRVNRNRINE----LNNSLGEIVKQQDTLTTYLNDYFDSVFVHRYRDVEPKIRVDCLQELGVWI 320

Human   320 KMYSDAFLNDSYLKYVGWTLHDRQGEVRLKCLKALQSLYTNRELFPKLELFTNRFKDRIVSMT-L 383
            ......|.:.|||:|:||.|.|....|||..:|.|:..:........|..|::|||:||:.|: :
pombe   321 NTVPSIFFSGSYLRYLGWMLSDINTTVRLTVVKVLRKFFETDSFIGGLRHFSSRFKERILEMSCV 385

Human   384 DKEYDVAVEAIRLVTLILHGSEEALSNEDCENVYHLVYSAHRPVAVAAGEFLHKKLFSRHDPQ-- 446
            |.:..|.|.:|||...:  .:...|.|.:...|..|:...:..|...|..||.|.:....:.:
pombe   386 DADIGVRVASIRLCNAM--RTCGFLENSEILKVLKLILDINPRVQREAVLFLCKVVDESVNEKID 448

Human   447 ---AEEALAKRRGRNS---------------------------------------PNGNLIRMLV 469
               .|:.:.|...:.|                                       .|||.|..:.
pombe   449 LWGEEDYILKAFSQTSLTTFSVHWIKFSQMCKLLEEVRLSYQSSFDYDTLLRIFQKNGNFITPIT 513

Human   470 LFFLESELHEHAAYLVDSLWESSQELLKDWECMTELL--------LEEPVQGEEA---MSDRQES 523
            ...|.       |..:||:::|       ||.::..:        |::|:....:   ::|.|||
pombe   514 QALLN-------ACEIDSIYQS-------WEDISNFVLFDNYTSTLKDPIDSILSFCKLNDFQES 564

Human   524 ALIELMVCTIRQAAEAH--PPVGRGTGKRVLTAKERKTQIDDRNKLTE-HFIITLPMLLS---KY 582
            .|::|:..:|:.....:  .|       :.:..|:.....:|:||..: .::..||.:.|   :.
pombe   565 ILLQLLSASIQTVCNNNFITP-------KTVHNKQAAETTNDQNKDKDLLYLNLLPYINSITERN 622

Human   583 SADAEKVANLLQIPQYFDLEIYSTGRMEKHLDALLKQIKFVVEKHVESDVLEACSKTY----SIL 643
            ||....:.:.|::....||...:..::.:|.:.|:..:|.....:.:..:::.|:..:    ||.
pombe   623 SASPTLLHDSLRLLFSMDLTEMTDPQLSRHFELLINNLKKFFLTNNDLQIIQGCTILFLRLDSIP 687

Human   644 CSEEYTIQNRVDIARSQLIDEFVDRF-NHSVEDLLQEGEEADDDDIYNV-LSTLKRLTSFHNAHD 706
            ..:|.......||. .|.:.||:..| :.:::|.:   ...|:..|:.. |:.::..||..:..|
pombe   688 ALKEDLKLLVTDIC-DQTVTEFLKNFGSFNIQDAV---ITKDEFVIFEACLTRIEGCTSLKDFSD 748

Human   707 LTKWDLFGNCYRLLKTGIEH--GAMPEQIVVQALQCSHYSILWQLVK---ITDGSPSKEDLLVLR 766
            ..::|:.   |..|.:.:..  .:..:.:...|:......:.|..::   ..|....|:|
pombe   749 YPEFDII---YERLVSLLSRVPNSYEDTLKFSAINTLQSLLFWFFLRKDNPADEEKKKDD----- 805

Human   767 KTVKSFLAVCQQCLSNVNTPVKEQAFMLLCDLLMIFSHQLMTGGREGLQPLVFNPDTGLQSELLS 831
             ..|.|     .||.|                                   :.|.|:   |::|.
pombe   806 -ETKVF-----NCLIN-----------------------------------IMNNDS---SKILQ 826

Human   832 FVMDHVFIDQDEENQSMEGDEEDEANKIEALHK--RRNLLAAFSKLI---IYDIVDMHAAADIFK 891
            ......|::.....:.::....::.|::...|.  :...|.|..|::   :|....:....  ||
pombe   827 LQAARTFLETVIMKEGVKASHYNDDNRVSEEHNFLKPQFLDALLKILEGWLYTYAKVGQFP--FK 889

Human   892 HYMKYYNDYGDII--KETLSKTRQIDKIQCAKT----LILSL--------QQLFNELVQEQGPNL 942
            ...:..:.:..|.  |..|:: |.::.:.|..|    :::||        .|.|.||....||.|
pombe   890 RLTQASSPHTQISLDKNPLNR-RLLEHVCCDLTSKLLIVVSLSNTITPEFSQQFCELRGHYGPKL 953

Human   943  942
            pombe   954  953

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STAG1	NP_005853.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..84		14/82 (17%)
		IRR1	12..>398	CDD:227824	106/392 (27%)
		STAG	160..273	CDD:462502	28/115 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1055..1096
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1129..1148
psc3	NP_001343016.1	IRR1	1..724	CDD:227824	166/754 (22%)