Protein Alignment STUB1 and CG34297

DIOPT Version :10

• Sequence 1: NP_005852.2
• Gene: STUB1 / 10273
• HGNCID: 11427
• Length: 303
• Species: Homo sapiens
• Sequence 2: NP_001097696.1
• Gene: CG34297 / 5740802
• FlyBaseID: FBgn0085326
• Length: 233
• Species: Drosophila melanogaster
• Alignment Length: 138
• Identity: 35/138 - (25%)
• Similarity: 61/138 - (44%)
• Gaps: 13/138 - (9%)

Human     6 EKEGGARLGAGGGSPEKSPSAQELKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRALCY 70
            ::...|||       |:...||..::.||..:....|..|...|..||.......:.|.|||||:
  Fly   106 DQRSKARL-------ERERVAQNFRKLGNAEYRKGNYEAAMKVYTEAIENIRDSHILYINRALCF 163

Human    71 LKMQQHEQALADCRRAL-ELDGQSVKAHFFLGQCQ--LEMESYDEAIANLQRAYSLAKEQRLNFG 132
            :|..:.::.:.||...| :||.::::|..:.....  |..||..|......|.::   .::::|.
  Fly   164 IKSGKFKRGIVDCDFVLNKLDEKNLRAWMYRAMAYKGLNDESNFENCVKYARKFN---SKQMDFI 225

Human   133 DDIPSALR 140
            ||....|:
  Fly   226 DDFLEKLK 233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STUB1	NP_005852.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		6/23 (26%)
		Spy	25..>124	CDD:443119	27/101 (27%)
		TPR 1	26..59		9/32 (28%)
		TPR repeat	26..54	CDD:276809	8/27 (30%)
		TPR repeat	59..89	CDD:276809	10/30 (33%)
		TPR 2	60..93		12/33 (36%)
		TPR repeat	94..122	CDD:276809	6/29 (21%)
		TPR 3	95..127		6/33 (18%)
		Required for interaction with MAPK7. /evidence=ECO:0000269|PubMed:20724525	101..200		9/42 (21%)
		CHIP_TPR_N	142..225	CDD:436460
		Required for interaction with and ubiquitination of MYOCD. /evidence=ECO:0000250|UniProtKB:A6HD62	142..196
		Required for ubiquitination of FOXO1. /evidence=ECO:0000269|PubMed:19483080	143..303
		Required for interaction with FOXO1. /evidence=ECO:0000269|PubMed:19483080	143..197
		RING-Ubox_CHIP	227..297	CDD:438316
CG34297	NP_001097696.1	NlpI	<104..>203	CDD:443815	27/103 (26%)
		TPR repeat	119..147	CDD:276809	8/27 (30%)
		TPR repeat	152..183	CDD:276809	10/30 (33%)
		TPR repeat	188..216	CDD:276809	5/27 (19%)