Protein Alignment STUB1 and Spag1

DIOPT Version :10

• Sequence 1: NP_005852.2
• Gene: STUB1 / 10273
• HGNCID: 11427
• Length: 303
• Species: Homo sapiens
• Sequence 2: NP_651514.1
• Gene: Spag1 / 43239
• FlyBaseID: FBgn0039463
• Length: 469
• Species: Drosophila melanogaster
• Alignment Length: 200
• Identity: 46/200 - (23%)
• Similarity: 95/200 - (47%)
• Gaps: 29/200 - (14%)

Human    21 EKSPSAQELKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVY-YTNRALCYLKMQQHEQALADCR 84
            ||...|:..:.:||..|..::|..|...|..:|..:|..||: |.|||:.:||::::..|::||:
  Fly   224 EKEQFAERHRLRGNESFKAKEYENAIEEYNCSIIYDPENAVHAYNNRAVAHLKLKKYFSAISDCQ 288

Human    85 RALELDGQSVKAHFFLGQCQLEMESYDEAIANLQRAYSLAKEQRLNFGDDIPSALRIAKKKRWNS 149
            ..|::|..::|||..:.:.......:.|::    ..|    ::.|:|..|             |:
  Fly   289 ACLQIDPMNIKAHLRMAEAHNAEGKHLESL----NVY----KKLLDFEPD-------------NA 332

Human   150 IEERRIHQESEL-----HSYLSRLIAAERE-RELEECQRNHEGDEDD-SHVRAQQACIEAKHDKY 207
            |.::.:.:.:.:     .|..:|||..|.: .:|:..:...|.::.: :.|:..:..:.||....
  Fly   333 IAKKAVEKLTSMLGEVAPSSATRLIIEEIDPPQLKTSEPKKEAEKSEPTVVKKPEPVVSAKKPPP 397

Human   208 MADMD 212
            :.|.|
  Fly   398 IKDYD 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STUB1	NP_005852.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		3/8 (38%)
		Spy	25..>124	CDD:443119	27/99 (27%)
		TPR 1	26..59		9/32 (28%)
		TPR repeat	26..54	CDD:276809	7/27 (26%)
		TPR repeat	59..89	CDD:276809	12/30 (40%)
		TPR 2	60..93		13/33 (39%)
		TPR repeat	94..122	CDD:276809	4/27 (15%)
		TPR 3	95..127		5/31 (16%)
		Required for interaction with MAPK7. /evidence=ECO:0000269|PubMed:20724525	101..200		15/105 (14%)
		CHIP_TPR_N	142..225	CDD:436460	13/77 (17%)
		Required for interaction with and ubiquitination of MYOCD. /evidence=ECO:0000250|UniProtKB:A6HD62	142..196		10/60 (17%)
		Required for ubiquitination of FOXO1. /evidence=ECO:0000269|PubMed:19483080	143..303		13/76 (17%)
		Required for interaction with FOXO1. /evidence=ECO:0000269|PubMed:19483080	143..197		10/60 (17%)
		RING-Ubox_CHIP	227..297	CDD:438316
Spag1	NP_651514.1	NlpI	<229..373	CDD:443815	38/164 (23%)
		TPR repeat	229..257	CDD:276809	7/27 (26%)
		TPR repeat	262..293	CDD:276809	12/30 (40%)
		TPR repeat	298..326	CDD:276809	5/35 (14%)