Protein Alignment STUB1 and CG6980

DIOPT Version :10

• Sequence 1: NP_005852.2
• Gene: STUB1 / 10273
• HGNCID: 11427
• Length: 303
• Species: Homo sapiens
• Sequence 2: NP_651289.1
• Gene: CG6980 / 42955
• FlyBaseID: FBgn0039228
• Length: 250
• Species: Drosophila melanogaster
• Alignment Length: 129
• Identity: 42/129 - (32%)
• Similarity: 63/129 - (48%)
• Gaps: 19/129 - (14%)

Human     6 EKEGGARLGAGGGSPEKSPSAQEL-KEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRALC 69
            ||:...|..|..    |:....|| :.|||..|..:||.:|...|.:||.:....|:.|.|||||
  Fly   111 EKDANDRAEARA----KAEYEAELQRSQGNEAFRSQKYEKAILHYDKAIIKVKDSAITYCNRALC 171

Human    70 YLKMQQHEQALADCRRALE------LDGQSVKAHFFLGQCQLEMESYDEAIANL------QRAY 121
            |:|:|.:::||.||:..||      |.....:||.:.|..|  .:.::|::...      |.||
  Fly   172 YIKLQNYKRALKDCQYVLEKLQESNLRAWLYQAHAYKGLKQ--DDKFEESVVKAREHNPKQLAY 233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
STUB1	NP_005852.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		7/24 (29%)
		Spy	25..>124	CDD:443119	37/110 (34%)
		TPR 1	26..59		12/33 (36%)
		TPR repeat	26..54	CDD:276809	11/28 (39%)
		TPR repeat	59..89	CDD:276809	16/35 (46%)
		TPR 2	60..93		17/38 (45%)
		TPR repeat	94..122	CDD:276809	8/34 (24%)
		TPR 3	95..127		8/33 (24%)
		Required for interaction with MAPK7. /evidence=ECO:0000269|PubMed:20724525	101..200		6/27 (22%)
		CHIP_TPR_N	142..225	CDD:436460
		Required for interaction with and ubiquitination of MYOCD. /evidence=ECO:0000250|UniProtKB:A6HD62	142..196
		Required for ubiquitination of FOXO1. /evidence=ECO:0000269|PubMed:19483080	143..303
		Required for interaction with FOXO1. /evidence=ECO:0000269|PubMed:19483080	143..197
		RING-Ubox_CHIP	227..297	CDD:438316
CG6980	NP_651289.1	Spy	117..>233	CDD:443119	38/121 (31%)
		TPR repeat	128..156	CDD:276809	11/27 (41%)
		TPR repeat	161..192	CDD:276809	16/30 (53%)
		TPR repeat	197..225	CDD:276809	6/29 (21%)