DRSC/TRiP Functional Genomics Resources

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Protein Alignment STUB1 and Sgt

DIOPT Version :10

Sequence 1:NP_005852.2 Gene:STUB1 / 10273 HGNCID:11427 Length:303 Species:Homo sapiens
Sequence 2:NP_609842.1 Gene:Sgt / 35052 FlyBaseID:FBgn0032640 Length:331 Species:Drosophila melanogaster


Alignment Length:170 Identity:47/170 - (27%)
Similarity:80/170 - (47%) Gaps:26/170 - (15%)


- Green bases have known domain annotations that are detailed below.


Human     9 GGARLGAGGG-------------------SPEKSPSAQELKEQGNRLFVGRKYPEAAACYGRAIT 54
            |.|.:||...                   :||....|:.:|.:||||....||.||...|.|||.
  Fly    80 GSAGIGAAAAAVPNNIDMFELFQSLYTERNPESLALAESIKNEGNRLMKENKYNEALLQYNRAIA 144

Human    55 RNPLVAVYYTNRALCYLKMQQHEQALADCRRALELDGQSVKAHFFLGQCQLEMESYDEAIANLQR 119
            .:|...::|.|||..::::.::|:|:.||:.||..:....||:..||.....|.::::|    ::
  Fly   145 FDPKNPIFYCNRAAAHIRLGENERAVTDCKSALVYNNNYSKAYCRLGVAYSNMGNFEKA----EQ 205

Human   120 AYSLAKEQRLNFGDDI-PSALRIAKKKRWNSIEERRIHQE 158
            ||  ||...|...::: .|.|..|:..|....:..|:.::
  Fly   206 AY--AKAIELEPDNEVYKSNLEAARNARNQPPQTGRLRED 243

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
STUB1NP_005852.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30 7/39 (18%)
Spy 25..>124 CDD:443119 33/98 (34%)
TPR 1 26..59 15/32 (47%)
TPR repeat 26..54 CDD:276809 13/27 (48%)
TPR repeat 59..89 CDD:276809 10/29 (34%)
TPR 2 60..93 10/32 (31%)
TPR repeat 94..122 CDD:276809 7/27 (26%)
TPR 3 95..127 10/31 (32%)
Required for interaction with MAPK7. /evidence=ECO:0000269|PubMed:20724525 101..200 13/59 (22%)
CHIP_TPR_N 142..225 CDD:436460 3/17 (18%)
Required for interaction with and ubiquitination of MYOCD. /evidence=ECO:0000250|UniProtKB:A6HD62 142..196 3/17 (18%)
Required for ubiquitination of FOXO1. /evidence=ECO:0000269|PubMed:19483080 143..303 2/16 (13%)
Required for interaction with FOXO1. /evidence=ECO:0000269|PubMed:19483080 143..197 2/16 (13%)
RING-Ubox_CHIP 227..297 CDD:438316
SgtNP_609842.1 SGTA_dimer 7..>48 CDD:465168
TPR 116..>233 CDD:440225 40/122 (33%)
TPR repeat 116..144 CDD:276809 13/27 (48%)
TPR repeat 149..179 CDD:276809 10/29 (34%)
TPR repeat 184..212 CDD:276809 10/33 (30%)
Blue background indicates that the domain is not in the aligned region.

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