Protein Alignment SIK1B and ppk9

DIOPT Version :9

• Sequence 1: NP_001307572.1
• Gene: SIK1B / 102724428
• -ID: -
• Length: 783
• Species: Homo sapiens
• Sequence 2: NP_593404.1
• Gene: ppk9 / 2541773
• PomBaseID: SPAC23H4.02
• Length: 532
• Species: Schizosaccharomyces pombe
• Alignment Length: 555
• Identity: 158/555 - (28%)
• Similarity: 240/555 - (43%)
• Gaps: 118/555 - (21%)

Human    24 VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRL-DSSNLEKIYREVQLMKLLNHPHII 87
            ||.:.:.||||:||.|.|||.:|..|..:||:|::....| |....:::.|||.:::.|:||:||
pombe    20 VGPWLLGRTLGQGNLAKVKLGKHFQTNEKVALKMVYNDELEDKDTWKRLQREVTILRQLHHPNII 84

Human    88 KLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKT 152
            .||||........:..|: .:.::...:..:..|.|...||.|.||:.|::|||.|.:.|||||.
pombe    85 TLYQVFRVPKYTVLALEY-MDTDLHSMVVKHNRLDECTTRKIFRQIVHAIDYCHLHRVAHRDLKL 148

Human   153 ENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVL 217
            ||:||:.::.:||.|||..||...|..|||.||:|.||||||.:|:.|:|..:|:|..|::||::
pombe   149 ENILLNKDLVVKLTDFGLSNFMLDGSFLSTSCGTPHYAAPEVIQGRYYDGCDVDVWGCGILLYLM 213

Human   218 VCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAE- 281
            :.|..||:...:..:..||.:|.:.||.|:|.....|||:||:|.|..||.:|:|.||.|..|:
pombe   214 LVGEFPFEDVTISNVLSRVCKGIYTIPSFVSSSASDLIRQMLMVLPTSRIKVAEIMQHPWFIADL 278

Human   282 PC---LPGPACPAFSAH-SYTSNLGD----YDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIY 338
            |.   ||.......|.| |.|.:..|    :|........::|...|.|..|..:.|
pombe   279 PTHSRLPSRTSSFSSKHRSVTFSPPDLAILFDPSITSPSSSVGQIPQPTDHSALSPS-------- 335

Human   339 YLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQA 403
                                    :|.|  :||.|.|.              |.|.:|..|..:
pombe   336 ------------------------KPMS--ISGTESPN--------------PDPASLCYSSYE- 359

Human   404 EMDCELQSSLQWPLFFPVDASCSGVFRPR--PVSPSSLLDTAISEEARQGPGLEEEQDTQESLPS 466
                :|.|:..|....   |..||...|.  |..||::.....|...|....:.:..:...|.|.
pombe   360 ----DLYSATSWHSDM---AESSGFLDPTDIPPIPSNVETLRSSLPQRHASFMNKVYNHPLSRPP 417

Human   467 STGRRHTLA---EVSTRLSPLTA----------------PC------------------------ 488
            :..|..:|.   .:.|..:|:..                ||
pombe   418 APNRLRSLRWHYGIQTAKNPIEVLRKLCEALLELGARFRPCDEESFLKENKYKVFSCITCHNSPV 482

Human   489 ------IVVSPSTTASPAEGTSSDSCLTFSASKSP 517
                  ..:.||.:......:|||..:.:::|.||
pombe   483 YLVIELFSIGPSASVIDIRFSSSDDSIKYTSSYSP 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIK1B	NP_001307572.1	STKc_SIK	26..278	CDD:270973	102/252 (40%)
		UBA_SIK1	300..349	CDD:270591	7/52 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	353..377		6/23 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..477		5/30 (17%)
ppk9	NP_593404.1	STKc_AMPK-like	22..273	CDD:270905	102/251 (41%)
		S_TKc	23..274	CDD:214567	102/251 (41%)
		AMPKA_C_like	426..531	CDD:302605	12/92 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910