DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IRX5 and Drgx

DIOPT Version :9

Sequence 1:	NP_005844.4	Gene:	IRX5 / 10265	HGNCID:	14361	Length:	483	Species:	Homo sapiens
Sequence 2:	NP_001097075.2	Gene:	Drgx / 5740176	FlyBaseID:	FBgn0085369	Length:	587	Species:	Drosophila melanogaster

Alignment Length:	450	Identity:	107/450 - (23%)
Similarity:	149/450 - (33%)	Gaps:	115/450 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    89 HTPGMAGSLGYHPYAA--PLGSYPYGDPAY-------RKNATRDATATLK-------AWLNEHRK 137
            |.|.:. :|.| |:||  |..||.| .||.       ||......|.||:       |:...|
  Fly    16 HPPRLP-TLDY-PFAATHPYTSYSY-HPAIHDETFVRRKQRRNRTTFTLQQLEELETAFAQTH-- 75

Human   138 NPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWTPRNRSEDEEEEENIDLEKNDED 202
              ||....:..||:...:|..:|..||.|.|.:.:|..::....|.|   |..|.:..|:|..:.
  Fly    76 --YPDVFTREDLAMKINLTEARVQVWFQNRRAKWRKAERLKDEQRKR---ENGESSSSLDKLHDS 135

Human   203 EPQKPEDKGD-------------PEGPEAGGAEQKAASGCERLQGPPTPAGKETEGSLSDSDFKE 254
            ....|:..|:             ...|.|.|..::..|.........:|.|..   .|..||.:.
  Fly   136 RESSPDITGEIDDDMDDLPPRQRSHSPLANGQMEQQHSHSHSHSHSRSPGGGM---HLDSSDNER 197

Human   255 PPSEGRLDALQ-------GPPRTGGPSPAGPAAARLAEDPAPHYP-AGAPAPGPHPAAG----EV 307
            |.|..:|.|..       |....|.|||:|....|      .|.| .|....||...:.    :.
  Fly   198 PLSSNQLTATPHSASQSLGSISAGSPSPSGMHRER------EHTPLVGGGGQGPSSPSNSRNTDS 256

Human   308 PPGPGGPSVI--------------HSPPPPPPPAVLAKPKLWSLAEIATSSDKVKDGGGGNEGSP 358
            |...|||..:              .|.|.|..|.....|...:.|..|..|....:.|||:..|.
  Fly   257 PIEVGGPMSLTTGSRMAASSNNSASSTPTPTTPHAPQMPHSSAAAAAAFGSHIFGNFGGGSNASD 321

Human   359 CPPCPGPIAGQALGGSRASPAPAPSRSPSAQCPFPGGTVLSRPLY--------YT-APFYPGYTN 414
            ......|:..:....:.|:.|.|..|  ||..|         ||:        :| .|.:||...
  Fly   322 SNCGFRPVLSEQSAVAAAAAAAAAQR--SANHP---------PLFLPPHLAAQFTHQPLFPGLKG 375

Human   415 YGSFGHLHG----HPGPGPG-----PTTGPGSHFNGLNQTVLNRADALAKDPKMLRSQSQ 465
            ...|..|..    .|.|.||     |.:.|.|            :.:.|..|:..:|..|
  Fly   376 VSPFQSLCSCCSLKPPPPPGSSVVAPLSIPVS------------SSSAASSPESPKSSGQ 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IRX5	NP_005844.4	Homeobox_KN	131..170	CDD:283551	11/38 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..392		56/253 (22%)
		IRO	327..344	CDD:214716	3/16 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	423..442		7/27 (26%)
Drgx	NP_001097075.2	Homeobox	56..108	CDD:278475	15/55 (27%)
Drgx	NP_001097075.2	OAR	428..445	CDD:281777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000