Protein Alignment ABCC4 and CG11898

DIOPT Version :10

• Sequence 1: NP_005836.2
• Gene: ABCC4 / 10257
• HGNCID: 55
• Length: 1325
• Species: Homo sapiens
• Sequence 2: NP_651679.2
• Gene: CG11898 / 43451
• FlyBaseID: FBgn0039645
• Length: 1320
• Species: Drosophila melanogaster
• Alignment Length: 1344
• Identity: 478/1344 - (35%)
• Similarity: 767/1344 - (57%)
• Gaps: 95/1344 - (7%)

Human     1 MLPVYQEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWD 65
            |..|:::.:|||:..||..|:.||.|...:...|.:|.|:..|:|...|...|..:...|.|.|:
  Fly     1 MSAVHEQRQPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWE 65

Human    66 KEVLRAENDAQKPSLTRAIIKCYWKSYLVLGI-FTLIEESAKVIQPIFLGKIINYFENYDPMDSV 129
            :|:.|:     ||::.|.|.|.|..|::...| ::::..:....||:.||.::::|.  :....:
  Fly    66 QELKRS-----KPNVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFS--ESTGKI 123

Human   130 ALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQI 194
            ..::||.||..:..|:||..:..|.:..::...|.|:|:|...::|||.||:|..|.....:|..
  Fly   124 TKHSAYLYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYA 188

Human   195 VNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFS 259
            ::|::.|:..|::.....|.||.|||:.:....:::..||...:.|:..::..:|||:...:..:
  Fly   189 ISLMATDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIA 253

Human   260 SLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCL-RGMNLAS 323
            ..:..:|...|.|::.|||:|..:::||||||||||:.||..:||:|:..|..|:.: .|:....
  Fly   254 RYKRSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQCTG 318

Human   324 FFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQT 388
            ..  ||:.:|::..|||..|.::|:.:||:..:.|..:..::...:|.||....|..|...|::.
  Fly   319 MI--SKLSLFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKD 381

Human   389 FLLLDEISQRNRQLPSDG---------------------------KKMVHVQDFTAFWDKASETP 426
            ||.       ..:.|:||                           .|.:.|...:|.||:..:..
  Fly   382 FLF-------QHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQEK 439

Human   427 T---LQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGT 488
            .   ::.:||..:..:.:.:||.||||||:||..:||||....|.|.|:|.::|..|:||:..|:
  Fly   440 RHRHIEDVSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGS 504

Human   489 LRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDA 553
            ||.||||.:.|:::||.:|::.|.|.:|::.|..||.|.:|:.|.:|||||||||:||||||:.|
  Fly   505 LRDNILFTEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKA 569

Human   554 DIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYT 618
            |||||||||||||:.||:.|.:.|:.:.|.:||.|||||::|.|:....:::|:.|::..:|.|
  Fly   570 DIYLLDDPLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHY- 633

Human   619 EFLKSGIDFGSLLKKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENVP 683
            :.||..|.|...:..|.|           ..:.|.....||:.:...|.||...  |..|...:.
  Fly   634 DALKKLIRFRMSVANDVE-----------VAKLRAMRTDSVYEEPEPRKSLSQE--EHMDRHEIE 685

Human   684 VTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVT 748
            ....|:.:. |.|..|.||.||:...|.:|.:.::|:...|:.:....|.:||.||
  Fly   686 QQFKEQQQI-GSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWA--------- 740

Human   749 VNGGGNVTEKLDLNWY-------------LGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNK 800
                  ..|:.:.|.:             :.:|:.|.:.|::|.:.|:...|.:.:..|..:|::
  Fly   741 ------TWEETEPNQHEPIPEYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQ 799

Human   801 MFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIA 865
            :|:.:::|.:.||.....||||||||.|:..:|..||...:|.|:..:..:.|::|......|:.
  Fly   800 LFQGVIRAFMHFFTLATSGRILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIWLL 864

Human   866 IPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAH 930
            ||...:..:....|..::..||.:||:|:.:|||::||.:::.:||.||||....:..:..|..:
  Fly   865 IPATVVVALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYY 929

Human   931 QDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLD--AGQVGLALSYALTLMGMF 993
            |:.::.|.:|.::.:|.||...|.||.::::.|.|..|:..|...  :|.||||::.::.|:.|.
  Fly   930 QNENTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMC 994

Human   994 QWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQK--RPPPAWPHEGVIIFDNVNFMYSPGGPL 1056
            |..:||:.|:||||.|||||:||.::..|..:|.::  ..|..||..|.:.|.::...||..||.
  Fly   995 QAGMRQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPY 1059

Human  1057 VLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIP 1121
            :||.||..|:.:||:||||.|.|||||::.|||||:...|.|.||...|:::||||||:::||||
  Fly  1060 ILKGLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAHINGHISIDGFETSQLGLHDLRRRISIIP 1124

Human  1122 QEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVC 1186
            |:||||:|::|.|||||.|.||||||.||:.|:|||.:.:|...::..|.:.|:|||:|||||||
  Fly  1125 QDPVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVC 1189

Human  1187 LARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGR 1251
            ||||:||:|:|||:|||||||||.||.|||:.|..||||||||||||||:|::|:|::||:|.||
  Fly  1190 LARALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGR 1254

Human  1252 LKEYDEPYVLLQNKESLFYKMVQQLGKAEAAALTETAKQVYFKR 1295
            :.|...|:.||.|:....::.|::.|...|..|...|:|.|.||
  Fly  1255 VVELGHPHELLHNRHGYLHRFVEKTGVGTAQHLRHLAEQSYRKR 1298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCC4	NP_005836.2	PLN03130	12..1277	CDD:215595	466/1313 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	657..688		7/30 (23%)
		PDZ-binding	1322..1325
CG11898	NP_651679.2	MRP_assoc_pro	2..1268	CDD:188098	467/1311 (36%)