Protein Alignment ABCC4 and CG31792

DIOPT Version :10

• Sequence 1: NP_005836.2
• Gene: ABCC4 / 10257
• HGNCID: 55
• Length: 1325
• Species: Homo sapiens
• Sequence 2: NP_724148.2
• Gene: CG31792 / 35163
• FlyBaseID: FBgn0051792
• Length: 1323
• Species: Drosophila melanogaster
• Alignment Length: 1348
• Identity: 568/1348 - (42%)
• Similarity: 826/1348 - (61%)
• Gaps: 88/1348 - (6%)

Human     6 QEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLR 70
            :::..||.:.:|:.|.:.||:..|.|..|.|..|...|:|..|.|.|::.||.:|...|..|:
  Fly     7 EDLPENPRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWANEL-- 69

Human    71 AENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAY 135
             |.:.:..||.|.:.:.:.:.::.||:.....|....:||:||.|:|:.|.|..|..:   ..||
  Fly    70 -ETNKKNASLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFSNPSPTSN---GVAY 130

Human   136 AYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSN 200
            |||..:...:.:..||.:.|.:.|...|:::||.:..|||||.|||:...:|:.:||.|:||:||
  Fly   131 AYAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISN 195

Human   201 DVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKT 265
            |:.:.|....|.|:||..||||:.||.|::.||||:.:.||..:::.:|||...||..|.||.||
  Fly   196 DLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLKT 260

Human   266 ATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILR---SSCLRGMNLASFFS- 326
            |..:|.|:|.|.|:|.||::|||||||..|..::.:.|.|||:.|..   :.||    :.||..
  Fly   261 AIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCL----IWSFNRF 321

Human   327 ASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLL 391
            .:.:.:|::...:||:|..:||...|:....|..||..:|.:|...:.:.:|.:|||:|:|..||
  Fly   322 LTPVSIFLSLVGFVLMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQKLLL 386

Human   392 LDEISQRNRQLPSDG-----------------------------KKMVHVQDFTAFWDKASETPT 427
            ..|:..::..:.|:|                             :..|.:.:..|.|...|...|
  Fly   387 SGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPMRAPEKPPHNSEDCVSISELKAKWTTNSPDYT 451

Human   428 LQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSN 492
            |.|::..|..|.|:|:||..|:|||||:.|:||||....|.:.|.|.::|.||:||:||||:|.|
  Fly   452 LSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMSYASQEPWLFSGTVRQN 516

Human   493 ILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYL 557
            ||||:..::.||:.|::.|||::|.:||...|.|::||||.:||||||||::|||:||:||.|||
  Fly   517 ILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYL 581

Human   558 LDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLK 622
            |||||||||:.|:|.|||.|:...|.:||.||||||||:|:.|.||:|::.||:...|||....|
  Fly   582 LDDPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESLHK 646

Human   623 SGIDFGSLLK---KDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENVPV 684
            ||:|||.:|.   .|||.:|.         |:||   ||:..|:  |.|:|.   .....|:.|.
  Fly   647 SGLDFGIVLDDPVNDNEAAED---------RSRT---SSITDQR--RSSVKS---VLSHAESCPE 694

Human   685 TLSEENRSE------GKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQS 743
            .:.||.:..      |:.|...|.:|||||..::.|..::.....:|....|.|::||.|.::..
  Fly   695 DVGEEQKINLQRQQLGRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSRNE 759

Human   744 ML---NVTVNGGGNVTEKLDLNWYLG---IYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMF 802
            .:   |.|       |:..|.::.:.   ||..:||.:::..|.||.|.|.:.:.:|..|||.||
  Fly   760 KMVAHNYT-------TDAKDADFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMF 817

Human   803 ESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIP 867
            ..|.:|.:.||::||.|.||||||||:|.:|::||...:..||..|...|.:.|...|.|...||
  Fly   818 RGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLIP 882

Human   868 LVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQD 932
            .:..||:..:||.::|:||.||||||::|||||:||.::||.||.||||:.|....:..||.:||
  Fly   883 ALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQD 947

Human   933 LHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCV 997
            :||.|.::|::|||.||..:|..|.:|:.::.....|...: .|..||||::.|:.|.|..||.|
  Fly   948 MHSSASYMFISTSRAFAYWMDIFCVLFIAMITLSFFIFPPS-SAADVGLAITQAMGLTGTVQWTV 1011

Human   998 RQSAEVENMMISVERVIEYTDLEKEAPWE--YQKRPPPAWPHEGVIIFDNVNFMYSP--GGPLVL 1058
            |||||:||.||||||:|||.::|.|.|.|  ..|:|..:||.:|.|.|..::..|.|  ....||
  Fly  1012 RQSAELENTMISVERMIEYEEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVL 1076

Human  1059 KHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQE 1123
            |.|:.:||.:|||||||||||||||||:||||||..:|.:.||...|.::||||||.|:||||||
  Fly  1077 KSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYNDGSVRIDDKDTNDMGLHDLRSKISIIPQE 1141

Human  1124 PVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLA 1188
            ||||:||:|.|||||:|::|:.||.||:||:||:.:..:...::|::.|.|||||||||||||||
  Fly  1142 PVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLA 1206

Human  1189 RAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLK 1253
            |||||.|:||::|||||||||:||.|||..||.||..|||||:||||:||:|||:::|:|:||:.
  Fly  1207 RAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVV 1271

Human  1254 EYDEPYVLL-QNKESLFYKMVQQLGKAEAAALTETAKQVYFKRNYPHI 1300
            |:..||.|| .:..:.|..:|:|.|:|....|.:.:::.:.|...|.:
  Fly  1272 EFGTPYELLTADDTNAFQDLVKQTGQATYDTLLKISQREFEKSEKPSL 1319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCC4	NP_005836.2	PLN03130	12..1277	CDD:215595	562/1317 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	657..688		8/30 (27%)
		PDZ-binding	1322..1325
CG31792	NP_724148.2	PLN03130	7..1313	CDD:215595	566/1340 (42%)