DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCC4 and MRP

DIOPT Version :9

Sequence 1:NP_005836.2 Gene:ABCC4 / 10257 HGNCID:55 Length:1325 Species:Homo sapiens
Sequence 2:NP_723772.2 Gene:MRP / 34686 FlyBaseID:FBgn0032456 Length:1549 Species:Drosophila melanogaster


Alignment Length:1360 Identity:501/1360 - (36%)
Similarity:765/1360 - (56%) Gaps:137/1360 - (10%)


- Green bases have known domain annotations that are detailed below.


Human    12 PLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEV-------L 69
            |...|:..||:.:.|.:.:...|::..|||.|::.:.|:|....:.......|::.|       .
  Fly   225 PELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKA 289

Human    70 RAENDAQ---------------------KPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFL 113
            |.|..||                     ..|:...|.|.:...:|...:..|..::....||..|
  Fly   290 RVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVL 354

Human   114 GKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKA 178
            ..||::.|   ..|:........||.:|.........:...||:.:...|:|:|.|:.:.|||||
  Fly   355 SLIISFVE---AQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKA 416

Human   179 LRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAV 243
            ||:||....::|.|:||||::.|..:|.::|.:|:.:|:.|||.......||.::|.|.|||:||
  Fly   417 LRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAV 481

Human   244 LIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEIS 308
            :|||:|:.........:.:.:...:.|.|::.||||::||:::|:||||.||...:.::|.|||:
  Fly   482 MIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIA 546

Human   309 KILRSSCLRGMNLASFFSASKIIV-FVTFTTYVLLGSV--ITASRVFVAVTLYGAVRLTVTLFFP 370
             .|||:.......:..:|.:..:| .|||.||||....  ::..:|.|::.|:..::|.:|: .|
  Fly   547 -TLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLSVEKVLVSIALFDLMKLPLTI-LP 609

Human   371 SAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV 435
            .....::|..||:.||..||..:|:...:....|.....:.:::....|   .:..||:.::..|
  Fly   610 MLSVDIAETQVSVNRINKFLNSEELDPNSVLHDSSKPHPMSIENGEFSW---GDEITLRNINIEV 671

Human   436 RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYE 500
            :.|.|:|:||.||:||||::.|.|||:....|:|:..|::|||.||.|:.:.|:|.|||||:.|:
  Fly   672 KKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYD 736

Human   501 KERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAV 565
            ::||.|||.||||:.|:.:|..||||.||::|..||||||.|::||||||.|||:||||||||||
  Fly   737 RKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAV 801

Human   566 DAEVSRHLFELCICQ--ILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFG 628
            ||.|.:|:||..|..  ||..|..:||||.:.:|.....|.::|.|::.:.||:.:.:|:...|.
  Fly   802 DAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFA 866

Human   629 SL----LKKDNEESEQ--------------PPVPGT-----PTLRNRTFSES-SVWSQQSSRPSL 669
            ..    |::.|||.|:              |.:.||     ...|..:.|:| ||    :|..||
  Fly   867 DFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISV----TSADSL 927

Human   670 KDGA---------LESQDTENVPVTLSEENRSEGK-----------VGFQAYKNYFRAGAHWIVF 714
            ..|.         .:|.|:.....:|.::...|||           |.|..||:|.::     |.
  Fly   928 MGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYIKS-----VG 987

Human   715 IFL----ILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVAT 775
            |||    ::||...|...:..:.||:.|||.|::        .|.|...|:  |||:|..     
  Fly   988 IFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNV--------ANDTGLRDM--YLGVYGA----- 1037

Human   776 VLFGIARSLLVFYVLV-------NSSQTLHNKMFESILKAPVL-FFDRNPIGRILNRFSKDIGHL 832
              ||..:.:|.::.:|       .:::|:||::...|::..|. |||..||||:||.||.|:..:
  Fly  1038 --FGFGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVV 1100

Human   833 DDLLPLT---FLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLES 894
            |:.||.|   |:.||..:|..:.|:|::..:  ::|: :||:..::.|.:|:::.|||.:.||||
  Fly  1101 DEELPATMDSFMTFIFMVLATIVVISLSTPI--FLAV-IVPIAFLYYFAQRFYVATSRQLMRLES 1162

Human   895 TTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMF 959
            .:|||::||.|.::.|..|||||...:|..|..||..|.:....:..:..:||.|:||:.:..  
  Fly  1163 VSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGN-- 1225

Human   960 VIIVAFGSL--ILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKE 1022
             :|:.|.||  :|....:.|.|||::||||.:.....|.||.|:::|..::||||:.||.:.::|
  Fly  1226 -LIILFASLFAVLGGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQE 1289

Human  1023 APWEYQ--KRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLI 1085
            ||||.:  |..|..||.||.:.|.|....|..|..|||:.::..|:..||||||||||||||||.
  Fly  1290 APWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLT 1354

Human  1086 SALFRLSEPE-GKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNA 1149
            .||||:.|.. |:|.||.:....:|||.||.:::||||:||||:|::|.|||||...||:|:|.|
  Fly  1355 LALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKA 1419

Human  1150 LQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDEL 1214
            |:...||..::.|...::.|:||.|.|.|||||||||||||:|||.::|::|||||.||..||:|
  Fly  1420 LELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDL 1484

Human  1215 IQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQ 1274
            |||.||.:|..|||||||||||||:||||::|||.|::.|:..|..||.|.:|.||.|.:
  Fly  1485 IQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAK 1544

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCC4NP_005836.2 CFTR_protein 11..1269 CDD:273530 498/1353 (37%)
ABC_membrane 96..365 CDD:294371 88/271 (32%)
ABCC_MRP_domain1 410..610 CDD:213217 97/201 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 657..688 10/40 (25%)
ABC_membrane 718..991 CDD:279056 94/285 (33%)
ABCC_MRP_domain2 1039..1258 CDD:213211 123/219 (56%)
PDZ-binding 1322..1325
MRPNP_723772.2 MRP_assoc_pro 14..1548 CDD:188098 501/1360 (37%)
ABC_membrane 338..601 CDD:279056 87/266 (33%)
ABCC_MRP_domain1 649..848 CDD:213217 97/201 (48%)
ABC_membrane 988..1260 CDD:279056 97/294 (33%)
ABCC_MRP_domain2 1308..1528 CDD:213211 123/219 (56%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151547
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.760

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