Protein Alignment ABCC4 and Sur

DIOPT Version :10

• Sequence 1: NP_005836.2
• Gene: ABCC4 / 10257
• HGNCID: 55
• Length: 1325
• Species: Homo sapiens
• Sequence 2: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Alignment Length: 2035
• Identity: 460/2035 - (22%)
• Similarity: 733/2035 - (36%)
• Gaps: 778/2035 - (38%)

Human     2 LPVYQEVKPNPLQD-----------ANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQ- 54
            |.||:|...:...|           |...|:..||||.||..:|:|..||.:|:..:..||.::
  Fly   201 LTVYKECYHDDYLDDYGKIGYKHSMATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARS 265

Human    55 HLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINY 119
            |....|..:.:|:    :.....|||....||..|:.:.:.||..|..:...:|.|:.:.||:.|
  Fly   266 HYDHFLYIYTEKK----KKSNSSPSLWYCYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEY 326

Human   120 FENY----------DPMDSVA---LNTAYAYAT----------------------------VLTF 143
            .|..          .|.:.||   |:|:....|                            .:.:
  Fly   327 IEQLYAQASEPPAKSPGNEVANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAW 391

Human   144 CTLILAI----LHHLYFYHVQCAGMRLRVAMCHMIYRKALRL-------SNMAMGKTTT------ 191
            ..|:.||    |.....:.:...|:|::.::..:||||:|.|       |:.:.|:..:
  Fly   392 IVLLAAITQGALSQASTHILNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSD 456

Human   192 ---------------------------GQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALL 229
                                       |.|.|.::.|.....:..:.:|:.||.|.:...|..||
  Fly   457 EKQKNDDSMATPEHVDNPSEPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLL 521

Human   230 WMEIGISCLAG-MAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEK 293
            :|.:|||.:.| :|.::|:.|||...|...|......|.:||.|::.:::.:.||::||:.||::
  Fly   522 YMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDE 586

Human   294 SFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGS----VITASRVFVA 354
            .|...|...|:||:..:.:.:....:.......|:.:|.|||...||.|..    .:.|||:|.:
  Fly   587 VFLKKIQEARRKELKYLNKDATFWTLMAVLTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFSS 651

Human   355 VTLYGAVRLTV-TLFFPSAIERVSEAIVSIRRIQTFLLLDEIS---------------------- 396
            :.|:  .:||| .|.||..:..:..|.||.||::.||...||.
  Fly   652 LALF--QQLTVPLLIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDM 714

Human   397 ----------------------------------------------------------------- 396
                                                                             
  Fly   715 YETQEKSNMTMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKL 779

Human   397 -QRNRQL---------------------------------------------PSDGKKMVHVQDF 415
             |:.|:|                                             |.|  ..|.:.|.
  Fly   780 VQQRRELLRNTPYVAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDD--IAVSINDG 842

Human   416 TAFWDKASETPTLQ----GLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG--R 474
            ...|...|:.|.:|    |:  .|..|:|..|||..|:||:|||||:|.|:....|.:..|.  .
  Fly   843 LFTWQPQSQMPVVQLHVPGI--IVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCT 905

Human   475 IAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQ 539
            |:|||||||:.:.|:|.|||||:.:..:||:.|::|||||.|::|:..|||::||:||..:||||
  Fly   906 ISYVSQQPWLLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQ 970

Human   540 KARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHE--KITILVTHQLQYLKAASQ 602
            :.|:.:|||:|..|::.::||||:::|.||..|:|:.||.::|.:  :..||||.||..:|.|..
  Fly   971 RQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEY 1035

Human   603 ILILKDGKMVQKGTYTE------------------------------------------------ 619
            ::.:|||::...|:|.:
  Fly  1036 LIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKL 1100

Human   620 ----------------------------------------------------------------- 619
                                                                             
  Fly  1101 GLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSS 1165

Human   620 ----------------------------------------------------------------- 619
                                                                             
  Fly  1166 IYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGD 1230

Human   620 -------------FLKSGIDFGSLLKKDNE---ESEQPPVPGT---PTLRNRTF----------- 654
                         :.:|.:|.|.|.....|   :|.|||...|   |..||.:.
  Fly  1231 VLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDV 1295

Human   655 --SESSVWSQQSSRPSLKD-------------------------------GALESQDTENVPV-- 684
              ||.:..|..||...|.|                               .::.|...|:.||
  Fly  1296 KKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVH 1360

Human   685 --------------TLSEE---------------------------------------------- 689
                          |.|||
  Fly  1361 FPASILATDGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNER 1425

Human   690 ------------------------NRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAA--QVAY 728
                                    .|..||:....|..|.||....|:.||.|   ||.  |...
  Fly  1426 HVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFI---TALIWQCLR 1487

Human   729 VLQDWWLSYWANKQSMLNVTVNGGGNVT-----EKLDLNWYLGIYSGLTVATVLFGIARSLLVFY 788
            |..|.||..|:|    ::..|...|:|.     :..::.:|..:|:.::...::..:..:....|
  Fly  1488 VYTDIWLQQWSN----VHGRVASKGHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQY 1548

Human   789 VLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGV 853
            ...|:.:.||:|:.::||...:.||...|:|||:||||.|:..:|..:..|....:|..|..:..
  Fly  1549 AGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSA 1613

Human   854 VSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYK 918
            :.:.|.:.|||.:..:|:...:..:::::..::|:::|:|:.|.|||.||||.::||:.||||:.
  Fly  1614 ILINVTITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFN 1678

Human   919 AEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAI--CAMFVIIVA----------------- 964
            .:.|..|:.....:.::.|:.|..|:.||..|.||.:  |.:||..|.
  Fly  1679 QQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATT 1743

Human   965 ----------FGSLILAKT-----LDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVI 1014
                      |.:..:.|:     .....||||::|.|.:.....|.|:..|::|....||||:.
  Fly  1744 SPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIA 1808

Human  1015 EY-------------TDLEKEAPWEYQ-------------------------------------- 1028
            .|             .|.:.:|..:::
  Fly  1809 HYAQGQDADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDG 1873

Human  1029 ----------------------------------------------------------------- 1028
                                                                             
  Fly  1874 DQQRIGGARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTS 1938

Human  1029 ----KRPPP---------------------------AWPHEGVIIFDNVNFMYSPGGPLVLKHLT 1062
                |:.||                           :||..|.|.||||:..|......|:.:||
  Fly  1939 VIKDKQLPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLT 2003

Human  1063 ALIKSQEKVGIVGRTGAGKSSLISALFR-LSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVL 1126
            ..|.:.:::||.||||:|||||..:||. |....|.|:||.:....|...:||.::|||||:..|
  Fly  2004 LKIPAGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHL 2068

Human  1127 FTGTMRKNLDPFNEHTDEELWNALQEVQLKETIE-DLPGKMDTELAESGSNFSVGQRQLVCLARA 1190
            |..|:|:||||.....|.:|||.|:..||||.:. .||..:||.:.:.|.|.|.|.|||:|||||
  Fly  2069 FNATIRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARA 2133

Human  1191 ILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEY 1255
            |||.:..|::||||:.:|..|:..:.|.....|...|::||||||.||:|.|:::|||.||:.|.
  Fly  2134 ILRGSVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVED 2198

Human  1256 DEPYVLLQNKESLFYKMVQQ 1275
            ..|..|.|.:.|:|..::::
  Fly  2199 GNPRELQQLEGSVFRGLLEK 2218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCC4	NP_005836.2	PLN03130	12..1277	CDD:215595	456/2025 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	657..688		10/77 (13%)
		PDZ-binding	1322..1325
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	90/382 (24%)
		TM helix 1	301..324	CDD:350035	6/22 (27%)
		TM helix 2	385..433	CDD:350035	11/47 (23%)
		TM helix 3	480..525	CDD:350035	12/44 (27%)
		TM helix 4	526..575	CDD:350035	15/48 (31%)
		TM helix 5	587..631	CDD:350035	10/43 (23%)
		TM helix 6	648..681	CDD:350035	11/34 (32%)
		ABCC_MRP_domain1	837..1043	CDD:213217	89/207 (43%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	91/342 (27%)
		TM helix 1	1475..1496	CDD:350046	10/23 (43%)
		TM helix 2	1520..1568	CDD:350046	9/47 (19%)
		TM helix 3	1575..1620	CDD:350046	14/44 (32%)
		TM helix 4	1621..1670	CDD:350046	15/48 (31%)
		TM helix 5	1682..1727	CDD:350046	14/44 (32%)
		TM helix 6	1777..1810	CDD:350046	10/32 (31%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	99/220 (45%)