Protein Alignment ABCC4 and CG7627

DIOPT Version :10

• Sequence 1: NP_005836.2
• Gene: ABCC4 / 10257
• HGNCID: 55
• Length: 1325
• Species: Homo sapiens
• Sequence 2: NP_609215.3
• Gene: CG7627 / 34148
• FlyBaseID: FBgn0032026
• Length: 1355
• Species: Drosophila melanogaster
• Alignment Length: 1368
• Identity: 597/1368 - (43%)
• Similarity: 862/1368 - (63%)
• Gaps: 106/1368 - (7%)

Human     7 EVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRA 71
            ::..||.:..|..|...||:..|.|..|.||.|:..|:|..|.|.:|:.||.:|...|:.|:
  Fly     8 DLPENPREHCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASWELEL--- 69

Human    72 ENDAQKPSLTRAIIKCYWKSYLVLG-IFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAY 135
            |....||:|.||:::.:...:.:|| :..|:|...:.:|||||.|:|.|:.:    .|.::.:||
  Fly    70 EKTKGKPNLLRALLRVFGWYFALLGLVLFLLELGLRTLQPIFLLKLIAYYTH----GSESIESAY 130

Human   136 AYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSN 200
            .||..:..|:.:..|:.|.|.......|:::||.||.||||||||||..|:|.||.|.:|||:||
  Fly   131 YYAAGVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLMSN 195

Human   201 DVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKT 265
            ||.:.|..|:|:|:||.|||:.:.:|.|::.||||:.:.|:|.:::.:|||:..||..|.||.:|
  Fly   196 DVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGKRTSVLRLRT 260

Human   266 ATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKI 330
            |..||.|:|.|||:|:||::|||||||..|.:::...|||||:.|...|.:||:.|:.....:::
  Fly   261 ALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGILLSFIIFLTRV 325

Human   331 IVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEI 395
            .:|::...|||||:.:|....|:....|..:|.|:|:|||..|.:::|.:|||:|:|.::..||.
  Fly   326 SIFLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVSIKRVQKYMQSDET 390

Human   396 S-------------------------------------------QRNRQLPSDGKKMVHVQDFTA 417
            :                                           ..|.:|...|   :.:....|
  Fly   391 NVMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLLGPPIATVNENAKLSEAG---ISISGLMA 452

Human   418 FWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQP 482
            .||..|...:|.|::..|:||.:|.:||..|:|||||:.|:||||....|.:.|:|.::|.||:|
  Fly   453 KWDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVNGSMSYASQEP 517

Human   483 WVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLAR 547
            |:||||:|.|||||:..::.||.||:|.|||::|.:||...|.|::|:||.:||||||||::|||
  Fly   518 WLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARISLAR 582

Human   548 AVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMV 612
            |||::..||||||||||||..|:|||||.|:...|.|:|.||.|||||:|:.|.||:|:..|::.
  Fly   583 AVYRETSIYLLDDPLSAVDTHVARHLFEQCMRGYLRERIVILATHQLQFLQHADQIVIMDKGRVS 647

Human   613 QKGTYTEFLKSGIDFGSLL--KKDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRP-------S 668
            ..|||....:||:||.|:|  .:.:|:||:         |:|:.|.|...|....|.       |
  Fly   648 AVGTYESLRESGLDFASMLADPERDEQSEE---------RSRSRSGSYTHSHSDQRRNSEQSLLS 703

Human   669 LKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDW 733
            :.|..::..:.|...   ::|.:..|::|.:.|..||:||..:..|..::.....:|....|.|:
  Fly   704 MADSCMDDLEAEQAN---NQERQEAGQIGLRLYSKYFKAGGGFFAFFVMMGFCVLSQGLASLGDY 765

Human   734 WLSYWANKQSMLNVTVNGGGNVT---EKLD------------------LNWYLGIYSGLTVATVL 777
            :||||..|:.  ||......|.|   |:|:                  |:.|  |::.:||.|:|
  Fly   766 FLSYWVTKKG--NVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTY--IFTVITVLTIL 826

Human   778 FGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLD 842
            ..:|||.|.|.:.:.:|..|||.||..|.:|.:.||:.||.||||||||||:|.:|::||...:|
  Fly   827 VTVARSFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMMD 891

Human   843 FIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSS 907
            .||..|.:.|:|.|...|.|...||.|.|||||..||.::|:|||||||:|:.|||||:|||::|
  Fly   892 VIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAAS 956

Human   908 LQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAK 972
            |.||.||||:.|:...:..||.:||:||.|:::|::|||.|...||..|.:::.|:.. |..:..
  Fly   957 LTGLSTIRAFGAQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDCFCVIYIAIITL-SFFIFP 1020

Human   973 TLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWE--YQKRPPPAW 1035
            ..:.|.||||::.|:.:.||.||.:|||||:||.|.:||||:||.|:|.|...|  ..|:||.:|
  Fly  1021 PANGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIEPEGALEAPADKKPPKSW 1085

Human  1036 PHEGVIIFDNVNFMYSPG--GPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKI 1098
            |.:|.|:||.::..|:|.  ...|||.|:.:||.:|||||||||||||||||:||||||..:|.:
  Fly  1086 PEQGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYNDGSV 1150

Human  1099 WIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLP 1163
            .|||..|:|:||||||.|:||||||||||:||||.|||||:|::|::||.:|:||:|||.:.|||
  Fly  1151 LIDKRDTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLP 1215

Human  1164 GKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTV 1228
            ..:.:::.|.|:||||||||||||||||||:|:||::|||||||||:||.|||..||.||..|||
  Fly  1216 SGLQSKITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTV 1280

Human  1229 LTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKES-LFYKMVQQLGKAEAAALTETAKQVY 1292
            |||||||:||:||||::|:|:||..|:..||.||...:| :|:.||:|.|.|...:|.:.|::.:
  Fly  1281 LTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMVKQTGHATYESLLKIAQKAF 1345

Human  1293 FKR 1295
            ..|
  Fly  1346 ENR 1348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCC4	NP_005836.2	PLN03130	12..1277	CDD:215595	591/1343 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	657..688		6/37 (16%)
		PDZ-binding	1322..1325
CG7627	NP_609215.3	PLN03130	13..1348	CDD:215595	595/1361 (44%)