Protein Alignment CNKSR1 and cnk

DIOPT Version :10

• Sequence 1: NP_001284576.1
• Gene: CNKSR1 / 10256
• HGNCID: 19700
• Length: 720
• Species: Homo sapiens
• Sequence 2: NP_725671.1
• Gene: cnk / 36952
• FlyBaseID: FBgn0286070
• Length: 1557
• Species: Drosophila melanogaster
• Alignment Length: 1079
• Identity: 194/1079 - (17%)
• Similarity: 311/1079 - (28%)
• Gaps: 428/1079 - (39%)

Human     4 VETWTPGKVATWLRGLDDSLQD--YPFEDWQLPGKNLLQLCPQSLEALAVRSLGHQELILGGVEQ 66
            :..|||.:|..|::|||:|::.  |.|...::.|:.||.:.|..||.|.:..:||||::|..||.
  Fly     6 IAEWTPDQVTDWIKGLDESMKGYLYEFSKQEIGGRALLNIRPYELENLGMLRIGHQEIVLEAVEN 70

Human    67 LQALSSRLQTENLQSLTEGLLGATHDFQSIVQGCLGDCAKTPIDVLCAAVELLHEADALLFWLSR 131
            |:.....|:.:|||.:...:..|..:....:.....:..|....:|......:.....|:..|.|
  Fly    71 LRNFHYHLKNDNLQFMALHVATAAKNLHRELARNHAESTKIDTRILHDITRTIATLKPLVGSLER 135

Human   132 YLFSHLNDF-SACQEIRDLLEELSQVLHEDGPAAEKEGTVLRICSHVAGICHNILVCCPKELLEQ 195
            ..|.....: ..|..:.....||:.:.|.|..|.:....:.:....:..:.:.::......::.|
  Fly   136 TPFRKQEMYREYCGNVLKCGLELATIAHRDRFALQPVPAIRQSAERLENLANFVIQDISDPMVLQ 200

Human   196 KAVLEQVQL---DSPLGLEIHTTSNCQHFVSQVDTQVPTDSRLQIQPGDEVVQINEQVVVREERD 257
            .|.|..|.|   :|.||..|.::.|..|.|:.:....|..:..:|:.|||:||||.|.|
  Fly   201 PASLNLVTLKKRESELGFNIESSYNGIHRVTDIKYNSPAHNSGKIEDGDEIVQINYQTV------ 259

Human   258 MVGWPRKNMVRELLREPAGLSLVLKK--------------------------------------- 283
             |||..:.::..|......:.|.:||
  Fly   260 -VGWQHRTVLEHLREALPDVVLTVKKRPKHTKMFGQIYMQPYRLPSKKRNMAARWAAQMPSPRAA 323

Human   284 -----------------IPIP-----------------------------ETPPQTPPQ------ 296
                             :|.|                             :.|..|.|:
  Fly   324 FLTLDTEQLATGGTGSAVPDPSKSLSSEKREVLTKANPVSSASDSDSSCSDIPTPTDPKLAAREI 388

Human   297 ------------------------------VLDSPHQRSPSL-SLAPLSPRAPS----------- 319
                                          |:.|.|:|.|.: |.....|.:||
  Fly   389 RLYYPKPRALLQRRNTICGCEYLSLKNSDLVVPSWHERKPGIGSPTNCDPGSPSIRDKSISFGYG 453

Human   320 ----------------------------------------------------------------- 319
                                                                             
  Fly   454 LEMAARPTTCIGIAGDTSTDKARRMFHEARKLKQLTEDSQREFLVDRYKPGVSKVVRFDAKEDYV 518

Human   320 ----------------------------EDVF--------------------------------- 323
                                        ||..
  Fly   519 MKNEKFICNVENTILETFEPIPFADEGDEDALETLRNCKTENAEELLEAINLATKGQDLPLAEAI 583

Human   324 --------------------AFDLSSNPS-----------------PGPSPAWTDSASLGPEPLP 351
                                |:|.|...|                 |.|.|.......:.|..:|
  Fly   584 NMPLLQQGRRGRLDKSHSTPAYDNSGEESDTPPAIEPRKEFLLVTPPAPPPRPRKQREMTPPAVP 648

Human   352 IPPEPPAIL-PAGVAGTPGLP-----------------ESPDKS-PVGRKKSKGLATRLSRRRVS 397
            .||..||.: ||....:..:|                 .:|.|| .:..||...|..:  ||..:
  Fly   649 PPPPKPASMQPASSITSISIPVPVPVPAAVDPSEISELHTPSKSRTLTLKKKHSLMAK--RRNTN 711

Human   398 CRELGRPDCDGWLLLRKAPGGFMG-PRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESG 461
            .:.||..|..|.|..||.  ...| ..|.|.:||:....||.:|..|...|..:|.:..:::...
  Fly   712 LKLLGTGDIQGHLYRRKK--NHRGVTYWARIYFVMLDTILYGFRSKQSTSASLVIFLPGFTVSLA 774

Human   462 HD-QKKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLITCISKYQSPGRAPPPR-------EEDC 518
            .: ..|.:.|::.|.. |.|.|||::|..|:.||..|      .|:..:.||..       .:|.
  Fly   775 KEVHSKPHAFKVYHTA-KSFYFAAESLDALNQWVDFL------RQASLKVPPSTGSKGGGDAKDL 832

Human   519 YSETEA--EDPDDEAGSHSASPSP------AQAGSPLHGDTSPAATPT--QRSPRTSFGSLTDSS 573
            |||.::  |:.|.....:.::|||      ......|.|.|.|::.|.  :|....||...|::.
  Fly   833 YSENDSSGEECDALVIQNLSTPSPQGNKESMSMSMTLSGGTPPSSAPIKHERGYLDSFRKFTNTF 897

Human   574 EEALEGMVRGLRQGGVSLLGQPQ---PLTQEQWRS-------SF---------------MRRNRD 613
            :               |...:|.   |:..||:||       ||               |...:.
  Fly   898 K---------------SSAAKPSSDIPVPTEQYRSYRKVPGGSFGIQIGANTPGYHDPAMPPTQI 947

Human   614 PQL-NERVHRVRALQSTLKAKLQELQVLEEVLGDPELTGEKFRQWKEQNRELYSEGLGAWGVAQA 677
            |.| ..::.|..:..|.:......:.:...:||.|.                 |........|..
  Fly   948 PPLVGPKLSRSSSRSSVVSGTESAVSLSASILGPPA-----------------SPAPTPTPTATP 995

Human   678 EGSSHILTSDSTEQSPHSLPSDPEEHSHLCPLTSESSLR 716
            ....|..:.:|..||....||            |:|||:
  Fly   996 TSLQHQSSEESPSQSQSQSPS------------SKSSLK 1022

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CNKSR1	NP_001284576.1	SAM_CNK1,2,3-suppressor	4..70	CDD:188910	26/67 (39%)
		CRIC_ras_sig	78..162	CDD:463138	15/84 (18%)
		PDZ_CNK1_2_3-like	195..282	CDD:467230	28/89 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	285..390		38/363 (10%)
		PH_CNK_mammalian-like	392..505	CDD:269962	33/114 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	504..573		21/85 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	676..720		10/41 (24%)
cnk	NP_725671.1	SAM_CNK1,2,3-suppressor	6..74	CDD:188910	26/67 (39%)
		CRIC_ras_sig	82..165	CDD:463138	14/82 (17%)
		PDZ_CNK1_2_3-like	203..283	CDD:467230	26/86 (30%)
		PH_CNK_insect-like	720..810	CDD:270135	27/92 (29%)