Protein Alignment SRRM1 and Srrm1

DIOPT Version :10

• Sequence 1: NP_001353524.1
• Gene: SRRM1 / 10250
• HGNCID: 16638
• Length: 918
• Species: Homo sapiens
• Sequence 2: NP_648627.1
• Gene: Srrm1 / 39483
• FlyBaseID: FBgn0036340
• Length: 954
• Species: Drosophila melanogaster
• Alignment Length: 1056
• Identity: 327/1056 - (30%)
• Similarity: 467/1056 - (44%)
• Gaps: 256/1056 - (24%)

Human     6 FRGTSAEQDNRFSNKQKKLLKQLKFAECLEKKVDMSKVNLEVIKPWITKRVTEILGFEDDVVIEF 70
            |.||:.:||.|||:|:|||:||:||.:||.|:||||||.|:|::|||:|::|:||..|||||:||
  Fly     3 FTGTNQQQDTRFSDKEKKLMKQMKFGDCLNKRVDMSKVKLDVLRPWISKKITDILHIEDDVVVEF 67

Human    71 IFNQL-EVKNPDSKMMQINLTGFLNGKNAREFMGELWPLLLSAQENIAGIPSAFLELKKEEIKQR 134
            ::||| |.|.|..|.||||:||||||:|||:||||||.|||||||:.:|||:.|::.||:||.:|
  Fly    68 VYNQLEEEKYPCPKKMQINMTGFLNGRNARQFMGELWALLLSAQESDSGIPAEFIQQKKDEILKR 132

Human   135 QIEQEKLASMKKQDEDKDK-RDKEEKESSR--EKRERSRSPRRRKSRSPSP-------------- 182
            :.||      :::|..:.: |.:.:::|||  .:|:||:|..|.:|||..|
  Fly   133 EEEQ------RQRDRSRSRSRSRSQRDSSRRDRQRDRSKSKSRSRSRSMKPANNNGSVPSAAREA 191

Human   183 ---------RRRSSPVRR--ERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQ 236
                     :|.||...|  .|:|..||.||.|::|||.:..  ||..:.| |.|:     .:|.
  Fly   192 AANAAAKIRKRGSSSAARPGSRERRSSRRPRSRSRSRSRTAG--KKTGSVE-PAPA-----KTVN 248

Human   237 EATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRR 301
            ...||.      |..|:|    |:.:..|:.........|||||||.|..|:||||.|. |.|||
  Fly   249 GRHSTD------KSSPVP----PASKNKSRSRSHSRSRSPRSRSRSPSAKRSRSRSSSR-RSRRR 302

Human   302 HRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRR--RSSASLSGSSSSSSS 364
            .||.|.|.||.|.....                  .|||:::.|:.:|  |::...|.||....:
  Fly   303 GRSSSISLSPERNQDQF------------------EHRRNKNSVQNKRQYRNNRGDSASSMERGN 349

Human   365 SRSRSPPKKPPKRTSSPPRKTRRLSPSASPP-------------------RRRHRPSPPATPPPK 410
            .|.|........|     |..||.||....|                   |||.|....:..|
  Fly   350 DRGRQFGGGGGGR-----RGGRRFSPRGRSPMRQDNGGGNGGNRFQRSNSRRRSRSRRLSRSP-- 407

Human   411 TRHSPTPQQSNRTRKSRV------SVSPGRTSG--KVTKHKG------------TEKRESPSPAP 455
            .|:|.:|::.|..|:|.:      ....||..|  ::.:|:|            .:.|.||....
  Fly   408 MRYSRSPRRFNNRRRSPMMNFRGGGRGGGRGGGHRQMWQHRGGSPNFRGGGRIHWQARHSPGGGG 472

Human   456 KPRKVELSESEEDKGGKMAAADSVQ--QRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVG 518
            :           ..||.|...|..|  |:.:|.|.::|        |..:..:|.|......: |
  Fly   473 R-----------GGGGGMGRFDRRQSPQQNRYNRDHRQ--------SPMQQNQPFRKQFSPHQ-G 517

Human   519 RRRRHSPSRSASPSPRKRQKETSPRMQMGKRWQSPVTKSGRRRRSPSPPPTRRRRSPSPAPPPRR 583
            ..||.|     ||..|:..::..|..:  :|..||....|...|..:|||.|.|||.|.:....|
  Fly   518 PGRRFS-----SPQQRRNSRDRRPNSR--ERRSSPGGGGGHMNRWDNPPPARNRRSSSGSSAGGR 575

Human   584 RRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRR 648
            ::      |:|:.|||.:|||...|  |..:.|..|.|     |::|    ...|...||..:..
  Fly   576 QQ------RQRSASPPEKRRSSHSR--SRSLSRNRSRS-----RSSS----QHSRKRESPIGRSS 623

Human   649 VSHSPP---------------------------PKQRSSPVTKRRSPS----------------- 669
            |.::.|                           |..|||..:..|:||
  Fly   624 VEYAGPAVNTIDLCREEQQRKNKPETIIVLDEGPAVRSSYASLSRTPSPFLKPHERLAAAKAAAA 688

Human   670 ----LSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTS-SSPPPVRRGASSSPQRRQS-P 728
                :..|.|..|..|.|...|.|....::.....:|...:|| .....|||.:.||....|| .
  Fly   689 ASAAVPKKSRDQSQSSSSDSSAESDDSEEQPRRKKQPTNMETSKGKKEKVRRSSESSTSSEQSDD 753

Human   729 SPSTRPIRRVSRTPEPKKIKKAAS-------PSPQSVRRVSSSRS-----VSGSPEPAA------ 775
            ..::....|:.:..:.:|.|:||:       ...:..:|.|..:|     .||..|..:
  Fly   754 EDNSSGDERLKKKLQQRKSKEAAALKGKEKEHEKEKDKRRSDKKSKRGAISSGDEESTSSRKRGH 818

Human   776 KKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKKHK 840
            ||.....:...|.|...:    ||.||.|. ...|:...:||.|...|:||.||.|||  .||.|
  Fly   819 KKTRRDEAGDNSDSEDEH----VPKKKRKK-AKKPADSSDSDSEASSKRKKHKKHKKH--SKKSK 876

Human   841 KHKKHKKEKAVAAAAAAAVT----------PAAIAAATTTLAQEEPVAAPEPKKETESEAEDNLD 895
            ||||||::.:...:.|.:.:          |.::||.....|.:..:..|     ..|.|....:
  Fly   877 KHKKHKRKCSAGKSRADSSSQGSSDEDEQLPHSVAAKRNGNAGKLALLLP-----GASGAGVINE 936

Human   896 DLEKHLREKALRSMRK 911
            ||||.|||:||:||:|
  Fly   937 DLEKQLRERALKSMKK 952

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SRRM1	NP_001353524.1	Necessary for mRNA 3'-end cleavage and cytoplasmic accumulation	1..156		87/151 (58%)
		Necessary for DNA and RNA-binding	1..151		86/145 (59%)
		PWI	46..115	CDD:460224	47/69 (68%)
		PHA03307	<620..>754	CDD:223039	37/190 (19%)
Srrm1	NP_648627.1	PWI	43..115	CDD:460224	48/71 (68%)