DRSC/TRiP Functional Genomics Resources

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Protein Alignment CDK9 and Cdk2

DIOPT Version :10

Sequence 1:NP_001252.1 Gene:CDK9 / 1025 HGNCID:1780 Length:372 Species:Homo sapiens
Sequence 2:NP_524420.1 Gene:Cdk2 / 42453 FlyBaseID:FBgn0004107 Length:314 Species:Drosophila melanogaster


Alignment Length:302 Identity:117/302 - (38%)
Similarity:170/302 - (56%) Gaps:21/302 - (6%)


- Green bases have known domain annotations that are detailed below.


Human    16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVN 80
            :..:::..|||:||:|.|:|||...|||.|||||:.:|.|.||.|.||:|||.:|:.|||.|||.
  Fly     5 LDNFQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLKHPNVVQ 69

Human    81 LIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKI 145
            |.::..:        ..::|::|::...||..|:......||...||..|..:|:.:.:.|.|:|
  Fly    70 LFDVVIS--------GNNLYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRI 126

Human   146 LHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNR-YTNRVVTLWYRPPELLLGERDYGPP 209
            ||||:|..|:|:...|.:|||||||||||::     |.| ||:.|||||||.||:|||.:.|...
  Fly   127 LHRDLKPQNLLVDTAGKIKLADFGLARAFNV-----PMRAYTHEVVTLWYRAPEILLGTKFYSTG 186

Human   210 IDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNY-ELYEKLELVKGQKR 273
            :|:|..|||.:||..|..:..|::|..||..|.:...:.....||.|... :...|....:|   
  Fly   187 VDIWSLGCIFSEMIMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLPDFKTKFPRWEG--- 248

Human   274 KVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315
               ..:...:.:..|.:||..:|..||..||.:.|||.|.:|
  Fly   249 ---TNMPQPITEHEAHELIMSMLCYDPNLRISAKDALQHAYF 287

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CDK9NP_001252.1 STKc_CDK9 6..315 CDD:270848 116/300 (39%)
T-loop 166..191 14/25 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 343..372
Cdk2NP_524420.1 STKc_CDK1_CdkB_like 8..287 CDD:270829 116/297 (39%)
Blue background indicates that the domain is not in the aligned region.

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