Protein Alignment CDK9 and Pitslre

DIOPT Version :10

• Sequence 1: NP_001252.1
• Gene: CDK9 / 1025
• HGNCID: 1780
• Length: 372
• Species: Homo sapiens
• Sequence 2: NP_649251.2
• Gene: Pitslre / 40292
• FlyBaseID: FBgn0016696
• Length: 952
• Species: Drosophila melanogaster
• Alignment Length: 359
• Identity: 132/359 - (36%)
• Similarity: 190/359 - (52%)
• Gaps: 46/359 - (12%)

Human    13 CDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77
            |..|.:::.|.:|.:||:|.|::|:.::|.:.||||::.||.||||||||:||||..|...:|.|
  Fly   552 CRSVEEFQCLNRIEEGTYGVVYRAKDKRTNEIVALKRLKMEKEKEGFPITSLREINTLLKGQHPN 616

Human    78 VVNLIEICRTKASPYNRCKGS----IYLVFDFCEHDLAGL---LSNVLVKFTLSEIKRVMQMLLN 135
            :|.:.||          ..||    |::|.|:.||||..|   :.|....|...|:|.:.|.||.
  Fly   617 IVTVREI----------VVGSNMDKIFIVMDYVEHDLKSLMETMKNRKQSFFPGEVKCLTQQLLR 671

Human   136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELL 200
            .:.::|.|.|||||:|.:|:|::..|:||:.||||||.:    .|...:||:.|||||||.||||
  Fly   672 AVAHLHDNWILHRDLKTSNLLLSHKGILKVGDFGLAREY----GSPIKKYTSLVVTLWYRAPELL 732

Human   201 LGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKL 265
            |....|..|||:|..|||.||.....|:..|.:|..:|..|.:..|:...::||.      |.:|
  Fly   733 LCSPVYSTPIDVWSVGCIFAEFLQMLPLFPGKSEIDELNRIFKELGTPNEKIWPG------YTEL 791

Human   266 ELVK---GQKRKVKDRLKAYVRDPY-------ALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPM 320
            ..||   .|..:..:...:.:|..:       .|.|:..||..||.||:.:|.||.|.||...|:
  Fly   792 PAVKNMLSQNSQFTEYPVSQLRKHFQEKTSEMGLSLLQGLLTYDPKQRLSADAALKHGFFKELPL 856

Human   321 PSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQST 354
            |.|         .|||.........|::..|.|:
  Fly   857 PID---------PSMFPTWPAKSELGARKAQASS 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK9	NP_001252.1	STKc_CDK9	6..315	CDD:270848	121/318 (38%)
		T-loop	166..191		10/24 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	343..372		3/12 (25%)
Pitslre	NP_649251.2	STKc_CDC2L1	552..851	CDD:173741	121/318 (38%)