Protein Alignment CDK9 and Eip63E

DIOPT Version :10

• Sequence 1: NP_001252.1
• Gene: CDK9 / 1025
• HGNCID: 1780
• Length: 372
• Species: Homo sapiens
• Sequence 2: NP_001261373.1
• Gene: Eip63E / 38433
• FlyBaseID: FBgn0005640
• Length: 538
• Species: Drosophila melanogaster
• Alignment Length: 361
• Identity: 124/361 - (34%)
• Similarity: 192/361 - (53%)
• Gaps: 47/361 - (13%)

Human     9 ECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73
            :.|| .:...|.||..:|:|::..|:|...:.|.|:||||::.:: |:||.|.||:||..:|:.|
  Fly   196 DSPF-GKQEAYVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQ-EEEGAPFTAIREASLLKEL 258

Human    74 KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLY 138
            ||.|:|.|.:|..|:.        ::..||::...||:..:...........::..:..||.||.
  Fly   259 KHSNIVTLHDIVHTRE--------TLTFVFEYVNTDLSQYMEKHPGGLDHRNVRLFLFQLLRGLS 315

Human   139 YIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGE 203
            |.|:.::||||:|..|:||:..|.|||||||||||.|:..::    |::.|||||||||::|||.
  Fly   316 YCHKRRVLHRDVKPQNLLISDCGELKLADFGLARAKSVPSHT----YSHEVVTLWYRPPDVLLGS 376

Human   204 RDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQH-QLALISQLCGSITPEVWPNVDNYELYEKLEL 267
            .:|...:|:||.|||..||.|..|...|..:.: ||..|.:|.|:.|.:.||.|.::..|:..:|
  Fly   377 TEYSTSLDMWGVGCIFVEMVTGMPTFPGIRDTYDQLDKIFKLLGTPTEDTWPGVTHFPGYKPHKL 441

Human   268 VKGQKRKVKDRLKAYVRDPYALDLID------KLLVLDPAQRIDSDDALNHDFFWSDP-----MP 321
            ...:.||:....      |...|:|:      ..|.|:|.||:.:||||.|.:|...|     :|
  Fly   442 GFYRPRKLGHNF------PRLYDIIEGETIANGFLQLNPEQRLGADDALQHPYFAQLPKKLYELP 500

Human   322 SDLKGMLSTHLTSMFE------YLAPPRRKGSQITQ 351
            .:         ||:|.      |..|.|:...::.|
  Fly   501 DE---------TSIFTVEGVQLYTEPNRQNKXKLKQ 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK9	NP_001252.1	STKc_CDK9	6..315	CDD:270848	114/312 (37%)
		T-loop	166..191		11/24 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	343..372		2/9 (22%)
Eip63E	NP_001261373.1	STKc_PCTAIRE_like	204..489	CDD:270835	112/303 (37%)