Protein Alignment CDK9 and Cdk5

DIOPT Version :10

• Sequence 1: NP_001252.1
• Gene: CDK9 / 1025
• HGNCID: 1780
• Length: 372
• Species: Homo sapiens
• Sequence 2: NP_477080.1
• Gene: Cdk5 / 36727
• FlyBaseID: FBgn0013762
• Length: 294
• Species: Drosophila melanogaster
• Alignment Length: 311
• Identity: 119/311 - (38%)
• Similarity: 177/311 - (56%)
• Gaps: 36/311 - (11%)

Human    16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVN 80
            :.||:|:.|||:||:|.|||.|:|.|.:.||||:|.::.:.||.|.:|||||.:|:.|||:|:|.
  Fly     1 MQKYDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVR 65

Human    81 LIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKI 145
            ||::..:..        .:.|||:.|:.||.....::..:..::..:..|..||.||.:.|.:.:
  Fly    66 LIDVLHSDK--------KLTLVFEHCDQDLKKYFDSLNGEIDMAVCRSFMLQLLRGLAFCHSHNV 122

Human   146 LHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPI 210
            ||||:|..|:||.::|.||||||||||||.:....    |:..|||||||||::|.|.:.|...|
  Fly   123 LHRDLKPQNLLINKNGELKLADFGLARAFGIPVKC----YSAEVVTLWYRPPDVLFGAKLYTTSI 183

Human   211 DLWGAGCIMAEMWTRS-PIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKL--------- 265
            |:|.||||:||:.... |:..|:....||..|.::.|:...:.||.|.:...|..|
  Fly   184 DMWSAGCILAELADAGRPLFPGSDVLDQLMKIFRVLGTPNEDSWPGVSHLSDYVALPSFPAITSW 248

Human   266 -ELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315
             :||        .||.:..|     ||:.|||:..|.|||.::.|:.|.:|
  Fly   249 SQLV--------PRLNSKGR-----DLLQKLLICRPNQRISAEAAMQHPYF 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK9	NP_001252.1	STKc_CDK9	6..315	CDD:270848	118/309 (38%)
		T-loop	166..191		11/24 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	343..372
Cdk5	NP_477080.1	STKc_CDK5	3..286	CDD:143344	118/307 (38%)