Protein Alignment CDK9 and Cdc2rk

DIOPT Version :10

• Sequence 1: NP_001252.1
• Gene: CDK9 / 1025
• HGNCID: 1780
• Length: 372
• Species: Homo sapiens
• Sequence 2: NP_523674.1
• Gene: Cdc2rk / 36051
• FlyBaseID: FBgn0013435
• Length: 387
• Species: Drosophila melanogaster
• Alignment Length: 332
• Identity: 126/332 - (37%)
• Similarity: 190/332 - (57%)
• Gaps: 41/332 - (12%)

Human    13 CDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHEN 77
            |..||::|||.::|:|::|.|::||..::.:.||||||.|:.||:|.||:.||||.||:...|||
  Fly    47 CRPVSEFEKLNRVGEGSYGIVYRARDTRSNEIVALKKVRMDQEKDGLPISGLREIMILKQCHHEN 111

Human    78 VVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHR 142
            :|.|.|:...|:      ..||:||.||||.|||.:|.|:...||.||:|.:...:|..|.|:|.
  Fly   112 IVRLREVVVGKS------LDSIFLVMDFCEQDLASVLDNMSQPFTESEVKCITLQVLKALKYLHS 170

Human   143 NKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYG 207
            ..::|||:|.:|:|:|..|.:|:|||||||.||    :.|...|.::||||||.||||||.|.:.
  Fly   171 RFMIHRDLKVSNLLMTDKGCIKVADFGLARMFS----NPPKPMTPQMVTLWYRAPELLLGCRTHT 231

Human   208 PPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN------VDNYELYE--- 263
            ..:|:|..|||:.|:....|::.||:|..||.:|..|.|:.:..:||.      |.|:.|.:
  Fly   232 TAVDMWAFGCILGELLLGKPLLPGNSEIAQLDMIIDLLGAPSESIWPGFADLPAVQNFTLSQQPY 296

Human   264 -----KLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSD 323
                 |..:: ||..:               :|::.|.:.:|..|..:::.|...:|...|...|
  Fly   297 NNLTPKFHMI-GQSGR---------------NLLNILFIYNPKTRATAEECLKSKYFVDPPQACD 345

Human   324 LKGMLST 330
             .||:.|
  Fly   346 -PGMMPT 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK9	NP_001252.1	STKc_CDK9	6..315	CDD:270848	120/315 (38%)
		T-loop	166..191		11/24 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	343..372
Cdc2rk	NP_523674.1	STKc_CDK10	45..353	CDD:173742	126/332 (38%)