Protein Alignment CDK9 and CG42366

DIOPT Version :10

• Sequence 1: NP_001252.1
• Gene: CDK9 / 1025
• HGNCID: 1780
• Length: 372
• Species: Homo sapiens
• Sequence 2: NP_723501.2
• Gene: CG42366 / 34319
• FlyBaseID: FBgn0259712
• Length: 706
• Species: Drosophila melanogaster
• Alignment Length: 372
• Identity: 111/372 - (29%)
• Similarity: 184/372 - (49%)
• Gaps: 57/372 - (15%)

Human    16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLME--NEKEGFPITALREIKILQLLKHENV 78
            :::|..|.::|.||:|.|...:.:.||:|||:|::..:  :.:|..   .|||:|.|:.|.|.|:
  Fly     1 MNRYITLTQLGDGTYGTVVLGQRKDTGEKVAIKRMKRKYYSWEEAM---NLREVKSLKKLSHPNI 62

Human    79 VNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRN 143
            |.|.|:.|.        ..::|.||::.:.:|..::.:........|:|.::..:|.||.::||:
  Fly    63 VKLKEVIRE--------NDTLYFVFEYMKENLYQMIKDRDTHLPEPELKSILFQVLTGLAFMHRH 119

Human   144 KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGP 208
            ...|||:|..|:|.:...::|:|||||||..    .|:| .:|:.|.|.|||.||:||...:||.
  Fly   120 GFFHRDLKPENLLCSGPDLIKIADFGLAREI----RSRP-PFTDYVSTRWYRAPEVLLHSTNYGS 179

Human   209 PIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKL-----ELV 268
            .||||..||||||::|..|:..|::|..||..|..:.|:...:.||  |.|.|...:     :.:
  Fly   180 TIDLWAMGCIMAELYTFRPLFPGSSEVDQLFKICSVLGTPDKDDWP--DGYRLASMIHFRYPDCI 242

Human   269 KGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLT 333
            |.....|..|.     ....|||::.:|..||.:|..:..:|.:.:|.:      ||.:..|..|
  Fly   243 KVPLSSVVSRC-----SQNGLDLLEDMLAYDPDKRPTAQQSLKYPYFHA------LKRISPTAAT 296

Human   334 -------------------SMFEYLAPPRRKGSQITQ--QSTNQSRN 359
                               |:...:.|.:.|...:|:  ..||.:.|
  Fly   297 KANVRLNSKYAASNGHPVQSVSNNVLPVQEKLQAVTELLHQTNNNMN 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK9	NP_001252.1	STKc_CDK9	6..315	CDD:270848	99/305 (32%)
		T-loop	166..191		11/24 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	343..372		5/19 (26%)
CG42366	NP_723501.2	STKc_MAK_like	4..284	CDD:270824	99/302 (33%)