DRSC/TRiP Functional Genomics Resources

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Protein Alignment RABEPK and Lztr1

DIOPT Version :9

Sequence 1:XP_005251697.1 Gene:RABEPK / 10244 HGNCID:16896 Length:380 Species:Homo sapiens
Sequence 2:NP_001259114.1 Gene:Lztr1 / 31037 FlyBaseID:FBgn0040344 Length:998 Species:Drosophila melanogaster


Alignment Length:295 Identity:67/295 - (22%)
Similarity:122/295 - (41%) Gaps:30/295 - (10%)


- Green bases have known domain annotations that are detailed below.


Human    32 PGDSPCARVGHSCSYLPPVGNAKRGKVFIVGGANPNRSFSDVHTMDLGKHQWDLDTCKGLLPRYE 96
            ||.|.|:....:.|.......:..||....|..:.|....| .|.....|||        ....|
  Fly   188 PGGSGCSMAYDAASNASSGSGSGSGKATSPGSYSCNALNVD-FTSYTATHQW--------TRMLE 243

Human    97 HASFIPS--------CTPDRIWVFGGANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSS 153
            .|.|:.:        ...|.::||||.|.....|.|.....:.::|.....|..||:|| :|.|:
  Fly   244 CAEFVGAKRSKHTVVAYKDAMFVFGGDNGKNMLNDLIRFGVKDKSWGRACATGTPPAPR-YHHSA 307

Human   154 AAIGNQLYVFGG--GERGAQPVQDTKLHVFD--ANTLTWSQPETLGNPPSPRHGHVMVAAGTKLF 214
            ...|:.:::|||  |:..:......|..:|:  ..:..|.:.:..|..|.||..|.......|::
  Fly   308 VVAGSSMFIFGGYTGDIHSNSNLTNKNDLFEYKFQSAMWVEWKFSGRQPVPRSAHGAAVYDNKMW 372

Human   215 IHGGLAGDRFYDDLHCIDIS-DMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTM 278
            |:.|..|:...:|:..:::: :.:|::::..|..|..|...........:|:|.|.:.....:::
  Fly   373 IYAGYDGNARLNDMWTLNLTGENQWEEVDQLGDRPPTCCNFPVAVARDAMYVFSGQSGLQITNSL 437

Human   279 YQYHTEEQHW------TLLKFDTLLPPG-RLDHSM 306
            :::|.:.:.|      .:|:..|..||. |..|:|
  Fly   438 FEFHFKTRTWRRISNEPVLRGATSAPPSRRYGHTM 472

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RABEPKXP_005251697.1 KELCH repeat 39..85 CDD:276965 10/45 (22%)
Kelch_2 39..84 CDD:284956 9/44 (20%)
KELCH repeat 94..143 CDD:276965 13/56 (23%)
Kelch_3 107..155 CDD:290151 16/47 (34%)
KELCH repeat 147..197 CDD:276965 12/53 (23%)
Kelch_3 157..209 CDD:290151 13/55 (24%)
Kelch_1 200..243 CDD:279660 9/43 (21%)
KELCH repeat 201..248 CDD:276965 9/47 (19%)
Kelch_1 251..291 CDD:279660 6/45 (13%)
KELCH repeat 251..291 CDD:276965 6/45 (13%)
Lztr1NP_001259114.1 PLN02153 237..554 CDD:177814 55/245 (22%)
KELCH repeat 252..298 CDD:276965 10/45 (22%)
Kelch_3 261..310 CDD:290151 16/49 (33%)
Kelch_5 299..>329 CDD:290565 10/30 (33%)
KELCH repeat 302..355 CDD:276965 12/53 (23%)
Kelch_1 358..400 CDD:279660 9/41 (22%)
KELCH repeat 359..407 CDD:276965 9/47 (19%)
KELCH repeat 410..455 CDD:276965 6/44 (14%)
Kelch_1 410..452 CDD:279660 6/41 (15%)
Kelch_1 466..509 CDD:279660 3/7 (43%)
KELCH repeat 467..509 CDD:276965 3/6 (50%)
BTB 564..704 CDD:279045
BTB 575..707 CDD:197585
SPOP_C_like 707..766 CDD:269810
BTB 798..898 CDD:279045
BTB 802..902 CDD:197585
SPOP_C_like 902..960 CDD:269810
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1494
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.940

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