DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HNRNPR and PAB1

DIOPT Version :9

Sequence 1:	NP_001095868.1	Gene:	HNRNPR / 10236	HGNCID:	5047	Length:	636	Species:	Homo sapiens
Sequence 2:	NP_011092.1	Gene:	PAB1 / 856912	SGDID:	S000000967	Length:	577	Species:	Saccharomyces cerevisiae

Alignment Length:	595	Identity:	134/595 - (22%)
Similarity:	204/595 - (34%)	Gaps:	166/595 - (27%)

- Green bases have known domain annotations that are detailed below.

Human     6 NGNAVQLKEEEEPMDTSSVTHTEHYKTLIEAGLPQKVAERLDEIFQTGL-VAYVDLDERAIDALR 69
            |.:|.....:.||    ||:....|......|....:....|.|.:|.| .|||:.::
Yeast    35 NSSASLYVGDLEP----SVSEAHLYDIFSPIGSVSSIRVCRDAITKTSLGYAYVNFND------- 88

Human    70 EFNEEGALSVLQQFKESDLSHVQNKSAFLCGVMKTYRQREKQGSKVQESTKGPDEAKIKALLERT 134
              :|.|..::.|      |::...|.. ||.:|  :.||:
Yeast    89 --HEAGRKAIEQ------LNYTPIKGR-LCRIM--WSQRD------------------------- 117

Human   135 GYTLDVTTGQRKYGGPPPDSVYSGVQPGIGTEVFVGKIPRDLYEDELVPLFEKAGPIWDLRLMMD 199
                   ...||.|        ||       .:|:..:..|:....|...|...|.|...::..|
Yeast   118 -------PSLRKKG--------SG-------NIFIKNLHPDIDNKALYDTFSVFGDILSSKIATD 160

Human   200 PLSGQNRGYAFITFCGKEAAQEAV-----KLCDSYEIRPGKHLGVCISVANNR------------ 247
            . :|:::|:.|:.|..:.||:||:     .|.:..||....||.     ...|
Yeast   161 E-NGKSKGFGFVHFEEEGAAKEAIDALNGMLLNGQEIYVAPHLS-----RKERDSQLEETKAHYT 219

Human   248 -LFVGSIPKNKTKENILEEFSKVTGLTEGLVDVILYHQPDDKKKNRGFCFLEYEDHKSAAQARRR 311
             |:|.:|....|.|...|.|:|.    ..:|...|....|.|.|  ||.|:.||.|:.|.:|...
Yeast   220 NLYVKNINSETTDEQFQELFAKF----GPIVSASLEKDADGKLK--GFGFVNYEKHEDAVKAVEA 278

Human   312 LMSGKVKVWGNVVTVEWADPVEEP-----------DPEVMAKVK--VLFVRNLATTVTEEILEKS 363
            |...::.  |..:.|..|....|.           ..|.|||.:  .|||:||..:|.:|.||:.
Yeast   279 LNDSELN--GEKLYVGRAQKKNERMHVLKKQYEAYRLEKMAKYQGVNLFVKNLDDSVDDEKLEEE 341

Human   364 FSEFGKLERVK-------KLKDYAFVHFEDRGAAVKAMDEMNGKEIEGEEIEIVLAKPPDKKRKE 421
            |:.:|.:...|       |.|.:.||.|.....|.||:.|.|.:.:.|:.:.:.:|:..|.:|.:
Yeast   342 FAPYGTITSAKVMRTENGKSKGFGFVCFSTPEEATKAITEKNQQIVAGKPLYVAIAQRKDVRRSQ 406

Human   422 RQAARQASRSTAYEDYYYHPPPRMPPPIRGRGRGGGRGGYGYPPDYYGYEDYYDDYYGYDYHDYR 486
            .....||.....|:.          ..........|..|...||.:||..    ...|..::...
Yeast   407 LAQQIQARNQMRYQQ----------ATAAAAAAAAGMPGQFMPPMFYGVM----PPRGVPFNGPN 457

Human   487 GGYEDPYYGYDDGYAVRGRGGGRGGRGAPPPPRGRGAP----PPRGRAGYSQRGAPLGPPRGSRG 547
            ....:|.             ||....|.  ||:.|..|    ||:|           |.||.:..
Yeast   458 PQQMNPM-------------GGMPKNGM--PPQFRNGPVYGVPPQG-----------GFPRNAND 496

Human   548 GRGGPAQQQR 557
            ......|:||
Yeast   497 NNQFYQQKQR 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HNRNPR	NP_001095868.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		4/17 (24%)
		NURR_hnRNPR	27..110	CDD:410955	19/83 (23%)
		hnRNP-R-Q	106..631	CDD:273732	111/494 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..459		6/43 (14%)
		Nuclear localization signal. /evidence=ECO:0000255	415..421		2/5 (40%)
		RNA-binding RGG-box	450..570		24/112 (21%)
		3 X 11 AA approximate repeats of D-D-Y-Y-G-Y-D-Y-H-D-Y	465..500		5/34 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..636		16/58 (28%)
PAB1	NP_011092.1	PABP-1234	38..559	CDD:130689	133/592 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910