DRSC/TRiP Functional Genomics Resources

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Protein Alignment HNRNPR and PRP24

DIOPT Version :9

Sequence 1:NP_001095868.1 Gene:HNRNPR / 10236 HGNCID:5047 Length:636 Species:Homo sapiens
Sequence 2:NP_013995.1 Gene:PRP24 / 855310 SGDID:S000004881 Length:444 Species:Saccharomyces cerevisiae


Alignment Length:288 Identity:70/288 - (24%)
Similarity:134/288 - (46%) Gaps:41/288 - (14%)


- Green bases have known domain annotations that are detailed below.


Human   165 TEVFVGKIPRDLYEDELVPLFEKAGPIWDLRLMMDPLSGQNRGYAFITFCGKEAAQEAV----KL 225
            |.|.|..:|:...::::...|:..|||..:. :.|.|. :|..:|.|.|...:.|..|:    |:
Yeast    41 TTVLVKNLPKSYNQNKVYKYFKHCGPIIHVD-VADSLK-KNFRFARIEFARYDGALAAITKTHKV 103

Human   226 CDSYEIRPGKHLGVCISVANNRLFVGSIPKNKTKENILEEFSKVTGLTEGLVDVILYHQPDDK-K 289
            ....||.. .||..|      .|::.:.|.:.|:.||.:....:.      |..:....|..: .
Yeast   104 VGQNEIIV-SHLTEC------TLWMTNFPPSYTQRNIRDLLQDIN------VVALSIRLPSLRFN 155

Human   290 KNRGFCFLEYEDHKSAAQARRRLMSGKVKVWGNVVTVEWADPVEEPDPEVMAKV--KVLFVRNLA 352
            .:|.|.:::....:.|.....:|  ..:|:.|..:..:.::|:|:......|.:  :.:.:|||:
Yeast   156 TSRRFAYIDVTSKEDARYCVEKL--NGLKIEGYTLVTKVSNPLEKSKRTDSATLEGREIMIRNLS 218

Human   353 TTVTEE-ILEKSFSEFGKLERV-----KKLKDY----AFVHFEDRGAAVKAMDEMNGKEIEGEEI 407
            |.:.:| :|.:||..||.:|::     :|...:    ||:.||::.:|.:|: :||...:...||
Yeast   219 TELLDENLLRESFEGFGSIEKINIPAGQKEHSFNNCCAFMVFENKDSAERAL-QMNRSLLGNREI 282

Human   408 EIVLAKPPDKKR-KERQAARQ--ASRST 432
            .:.||   |||. .||...::  |||::
Yeast   283 SVSLA---DKKPFLERNEVKRLLASRNS 307

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HNRNPRNP_001095868.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
NURR_hnRNPR 27..110 CDD:410955
hnRNP-R-Q 106..631 CDD:273732 70/288 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 415..459 8/21 (38%)
Nuclear localization signal. /evidence=ECO:0000255 415..421 3/6 (50%)
RNA-binding RGG-box 450..570
3 X 11 AA approximate repeats of D-D-Y-Y-G-Y-D-Y-H-D-Y 465..500
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 504..636
PRP24NP_013995.1 RRM1_Prp24 41..113 CDD:409737 19/74 (26%)
RRM2_Prp24 117..195 CDD:409738 14/91 (15%)
RRM3_Prp24 210..286 CDD:409739 22/76 (29%)
RRM4_Prp24 312..386 CDD:409740
Lsm_interact 425..443 CDD:398843
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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