DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HNRNPR and Syp

DIOPT Version :9

Sequence 1:NP_001095868.1 Gene:HNRNPR / 10236 HGNCID:5047 Length:636 Species:Homo sapiens
Sequence 2:NP_001262777.1 Gene:Syp / 42460 FlyBaseID:FBgn0038826 Length:761 Species:Drosophila melanogaster


Alignment Length:745 Identity:328/745 - (44%)
Similarity:419/745 - (56%) Gaps:143/745 - (19%)


- Green bases have known domain annotations that are detailed below.


Human     2 ANQVNGNAVQLKE-EEEPMDTSSVTHTEHYKTLIEAGLPQKVAERLDEIFQTGLVAYVDLDERAI 65
            :....||...|.: .::..|......||.|..|:|.||.:|||.:||||::||.:|:.:|||||:
  Fly    41 SKMAEGNGELLDDINQKADDRGDGERTEDYPKLLEYGLDKKVAGKLDEIYKTGKLAHAELDERAL 105

Human    66 DALREFNEEGALSVLQQFKESDLSHVQNKSAFLCGVMKTYRQREK---QGSKVQESTKGPDEAKI 127
            |||:||..:|||:||.||.||:|.||.||||:||||||||||:.:   ||.....:.|||||.||
  Fly   106 DALKEFPVDGALNVLGQFLESNLEHVSNKSAYLCGVMKTYRQKSRASQQGVAAPATVKGPDEDKI 170

Human   128 KALLERTGYTLDVTTGQRKYGGPPPDSVYSGVQPGIGTEVFVGKIPRDLYEDELVPLFEKAGPIW 192
            |.:||||||||||||||||||||||.  :.|..||.|.|||.||||:|:|||||:||||..|.||
  Fly   171 KKILERTGYTLDVTTGQRKYGGPPPH--WEGNVPGNGCEVFCGKIPKDMYEDELIPLFENCGIIW 233

Human   193 DLRLMMDPLSGQNRGYAFITFCGKEAAQEAVKLCDSYEIRPGKHLGVCISVANNRLFVGSIPKNK 257
            ||||||||::|.||||||:||..:|||..||:..:.:|||.||.:||.||..|:|||||:||||:
  Fly   234 DLRLMMDPMTGTNRGYAFVTFTNREAAVNAVRQLNDFEIRTGKKIGVTISFNNHRLFVGNIPKNR 298

Human   258 TKENILEEFSKVTGLTEGLVDVILYHQPDDKKKNRGFCFLEYEDHKSAAQARRRLMSGKVKVWGN 322
            .::.::|||||   ...||.:||:|..||||||||||||||||.||:|:.|:|||.:|::||||.
  Fly   299 DRDELIEEFSK---HAPGLYEVIIYSSPDDKKKNRGFCFLEYESHKAASLAKRRLGTGRIKVWGC 360

Human   323 VVTVEWADPVEEPDPEVMAKVKVLFVRNLATTVTEEILEKSFSEFGKLERVKKLKDYAFVHFEDR 387
            .:.|:||||.||||.:.|:|||||:||||...|:|:.|::.|.::||:|||||:|||||:|||||
  Fly   361 DIIVDWADPQEEPDEQTMSKVKVLYVRNLTQDVSEDKLKEQFEQYGKVERVKKIKDYAFIHFEDR 425

Human   388 GAAVKAMDEMNGKEIEGEEIEIVLAKPPDKKRKERQAARQASRS-----------TAYEDY--YY 439
            .:||:||..:|||||....||:.|||||..|:|:.:..|...|.           ..:|..  |.
  Fly   426 DSAVEAMRGLNGKEIGASNIEVSLAKPPSDKKKKEEILRARERRMMQMMQARPGIVGFETLSPYR 490

Human   440 HPPPRMP-----PPIRGRGRGGGR----GGYGYPPDYYGYED------------YYDDYY----- 478
            :..|..|     .|:|...|...|    ..|.|..|::|:.|            ||||.|     
  Fly   491 NLSPTHPSIMSLTPMRPGARMPLRTPIPREYDYFYDFFGFSDYRQGGSFGNNVSYYDDMYRWIDG 555

Human   479 GYDYHDYRGGYEDPYYGYDDGYAVRGRGGG------------------------RGGRGAPPPP- 518
            .|:|:||..|          |....|.|||                        |..||:...| 
  Fly   556 DYNYYDYPNG----------GGGGSGGGGGSVSGGTVLPLSAGGSQNSPMASGQRSARGSASGPS 610

Human   519 ---------RGRGAPPPRGRAGYSQRGA---------PLGPPRGSRGGRGGPAQQQRGRGSRGSR 565
                     ||.|...||||. ..|||:         |......:..|:...|..|||...:|:.
  Fly   611 ASPSLMGVGRGHGITVPRGRV-VGQRGSISRLGAQTVPQAAGAAAAAGQAAAAVAQRGATGQGAP 674

Human   566 GNRGGNVG-----------------------GKRKADG--YNQPDSKRRQTN----NQQNWGSQP 601
            ...||..|                       ||||.||  .|..|.|||..:    |..:|||.|
  Fly   675 AATGGFRGVLPTRPSARGTQHVKPLQNLPVVGKRKFDGGHQNPADVKRRYPSGLIGNGGSWGSLP 739

Human   602 IAQQPLQQGGDYSGNYGYNNDNQEFYQDTY 631
            :.||||...|            :::|.||:
  Fly   740 LPQQPLGTNG------------EQWYMDTF 757

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HNRNPRNP_001095868.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24 4/22 (18%)
NURR_hnRNPR 27..110 CDD:410955 53/82 (65%)
hnRNP-R-Q 106..631 CDD:273732 272/638 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 415..459 13/65 (20%)
Nuclear localization signal. /evidence=ECO:0000255 415..421 2/5 (40%)
RNA-binding RGG-box 450..570 44/183 (24%)
3 X 11 AA approximate repeats of D-D-Y-Y-G-Y-D-Y-H-D-Y 465..500 13/51 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 504..636 52/200 (26%)
SypNP_001262777.1 RRM1_hnRNPR_like 205..283 CDD:240695 50/77 (65%)
RRM2_hnRNPR_like 286..367 CDD:240696 49/83 (59%)
RRM3_hnRNPR_like 381..452 CDD:240697 42/70 (60%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 102 1.000 Domainoid score I6857
eggNOG 1 0.900 - - E1_KOG0117
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 548 1.000 Inparanoid score I1152
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49453
OrthoDB 1 1.010 - - D1384330at2759
OrthoFinder 1 1.000 - - FOG0000581
OrthoInspector 1 1.000 - - otm41244
orthoMCL 1 0.900 - - OOG6_104511
Panther 1 1.100 - - LDO PTHR21245
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R9312
SonicParanoid 1 1.000 - - X331
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.870

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