DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment STX6 and Syx6

DIOPT Version :9

Sequence 1:	NP_005810.1	Gene:	STX6 / 10228	HGNCID:	11441	Length:	255	Species:	Homo sapiens
Sequence 2:	NP_995816.1	Gene:	Syx6 / 40373	FlyBaseID:	FBgn0037084	Length:	339	Species:	Drosophila melanogaster

Alignment Length:	323	Identity:	131/323 - (40%)
Similarity:	179/323 - (55%)	Gaps:	80/323 - (24%)

- Green bases have known domain annotations that are detailed below.

Human     6 PFFVVKGEVQKAVNTAQGLFQRWTELLQDPSTATREEIDWTTNELRNNLRSIEWDLEDLDETISI 70
            ||  ...||.||:|..:||:.||.||.::..|    |.:|||.||||:|||||||||||::||||
  Fly    24 PF--PNSEVFKALNKTRGLYLRWRELGENGGT----EAEWTTTELRNSLRSIEWDLEDLEDTISI 82

Human    71 VEANPRKFNLDATELSIRKAFITSTRQVVRDMKDQMSTS-----SVQA----------------- 113
            ||.||.||.:|..|||.|:.||.:||..|:.|||:||.:     .:.|
  Fly    83 VEKNPSKFRIDNRELSSRRHFIDNTRDEVKQMKDKMSLNRSRDRDITAHQPLLDNDRHSPNHNHS 147

Human   114 -----------------------LAERKNRQALLGDSGSQ--NWSTGTTD------------KYG 141
                                   |.|..|..:|: :||||  |...||..            ||.
  Fly   148 IAIPNSNSNSNEYHQHPHNDRTYLVECPNGNSLI-NSGSQVANTIAGTMSAAAAAASRHSGTKYS 211

Human   142 RLDRELQRAN-------------SH-FIEEQQAQQQLIVEQQDEQLELVSGSIGVLKNMSQRIGG 192
            :|:..|...:             || ::.|..:.||.:::.|||||:::|.|||.||.:|::||.
  Fly   212 KLENALDSPSHYGQTHHGGMDSPSHRYVGETVSIQQRMIQGQDEQLDMISDSIGTLKTVSRQIGV 276

Human   193 ELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQWCAIAILFAVLLVVLILFLVL 255
            ||:||||||:||.:|.::|:|:||..|||:|||.||.:|:|||.||.||..:||.|:|||::|
  Fly   277 ELDEQAVMLDDFGNEFDTTESKLDTTMKKVAKVLHMNNDKRQWAAILILSGLLLFVIILFIIL 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
STX6	NP_005810.1	SNARE_NTD_STX6	5..107	CDD:410573	56/100 (56%)
STX6	NP_005810.1	SNARE_Syntaxin6	166..231	CDD:277204	37/64 (58%)
Syx6	NP_995816.1	Syntaxin-6_N	29..115	CDD:286286	51/89 (57%)
Syx6	NP_995816.1	SNARE_Syntaxin6	250..315	CDD:277204	37/64 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154218
Domainoid	1	1.000	104	1.000	Domainoid score	I6700
eggNOG	1	0.900	-	-		E1_KOG3202
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H115622
Inparanoid	1	1.050	212	1.000	Inparanoid score	I3650
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53942
OrthoDB	1	1.010	-	-		D1563292at2759
OrthoFinder	1	1.000	-	-		FOG0003084
OrthoInspector	1	1.000	-	-		otm42236
orthoMCL	1	0.900	-	-		OOG6_101619
Panther	1	1.100	-	-	O	PTHR19957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1528
SonicParanoid	1	1.000	-	-		X3993
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800