DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF443 and CG11247

DIOPT Version :9

Sequence 1:	NP_005806.3	Gene:	ZNF443 / 10224	HGNCID:	20878	Length:	671	Species:	Homo sapiens
Sequence 2:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	351	Identity:	112/351 - (31%)
Similarity:	166/351 - (47%)	Gaps:	43/351 - (12%)

- Green bases have known domain annotations that are detailed below.

Human   223 KPYECKQCSKAFSFYSSYLRHERTHTGEKPYECKQCSKAFPFYSSYLRHERT-HTGEKPYKCKQC 286
            |.:.|.||||.|...:...||...|:.|:|::||.|.|::....:...|..| |...|.:.|.||
  Fly    91 KHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQC 155

Human   287 SKAFPDSSSCLIHERTHTGEKPYTCKQCGKAFSVSGSLQRHETTH--SAEKPYACQQCGKAFHHL 349
            .|:|.......:|.|.|:|||||.|..|.|.|:..|.||:|..:|  ::.:.:.|.:|..:|...
  Fly   156 PKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTN 220

Human   350 GSFQRHMIRHTGNGPHKCKICGKGFDCPSSLQSH-ERTHTGEKPYECKQCGKALSHRSSFRSHMI 413
            .:.:.||.||.....|:|.||...|....:|::| .:.|.....:||:.|.|.:.......:||.
  Fly   221 ANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQ 285

Human   414 MHTGDGPHKCKVCGKAFVYPSVFQRHERTHTAEKPYKCKQCGKAYRISSSLRRHETTHTGEKPYK 478
            .||....|.|:||...|...|.:..|.|.||.|:||:|:.|.:.:..||.|:.|...||||||::
  Fly   286 RHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFR 350

Human   479 CKLGKACIDFCSFQNHKTTHTGEKPYECKECGKAFSRFRYLSRH-KRTHTGEKPYECKTCRKAFG 542
            |:|                        |:: ..|||:..:|..| |:.|..:|||.|:.|...|
  Fly   351 CQL------------------------CED-EVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFF- 389

Human   543 HYDNLKVHERIH---------SGEKP 559
               .:||..:.|         .|:||
  Fly   390 ---KIKVELQSHVEHCAKCPVDGDKP 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF443	NP_005806.3	KRAB	3..43	CDD:307490
		C2H2 Zn finger	133..163	CDD:275368
		C2H2 Zn finger	171..191	CDD:275368
		COG5048	196..579	CDD:227381	112/351 (32%)
		C2H2 Zn finger	199..219	CDD:275368
		C2H2 Zn finger	227..247	CDD:275368	8/19 (42%)
		C2H2 Zn finger	255..275	CDD:275368	6/20 (30%)
		C2H2 Zn finger	283..303	CDD:275368	7/19 (37%)
		C2H2 Zn finger	311..331	CDD:275368	8/19 (42%)
		C2H2 Zn finger	339..359	CDD:275368	5/19 (26%)
		C2H2 Zn finger	367..387	CDD:275368	6/20 (30%)
		C2H2 Zn finger	395..415	CDD:275368	5/19 (26%)
		C2H2 Zn finger	423..443	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	506..526	CDD:275368	7/20 (35%)
		C2H2 Zn finger	534..554	CDD:275368	5/19 (26%)
		C2H2 Zn finger	562..582	CDD:275368
		C2H2 Zn finger	590..610	CDD:275368
		C2H2 Zn finger	618..638	CDD:275368
		C2H2 Zn finger	651..671	CDD:275368
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	54/155 (35%)
		C2H2 Zn finger	95..115	CDD:275368	8/19 (42%)
		zf-H2C2_2	107..132	CDD:290200	9/24 (38%)
		C2H2 Zn finger	123..144	CDD:275368	6/20 (30%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	12/23 (52%)
		C2H2 Zn finger	180..200	CDD:275368	8/19 (42%)
		COG5048	<192..369	CDD:227381	59/201 (29%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	9/22 (41%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		C2H2 Zn finger	351..374	CDD:275368	9/47 (19%)
		C2H2 Zn finger	382..399	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910