DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF443 and salr

DIOPT Version :9

Sequence 1:	NP_005806.3	Gene:	ZNF443 / 10224	HGNCID:	20878	Length:	671	Species:	Homo sapiens
Sequence 2:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster

Alignment Length:	903	Identity:	184/903 - (20%)
Similarity:	278/903 - (30%)	Gaps:	360/903 - (39%)

- Green bases have known domain annotations that are detailed below.

Human    73 ESKDGTQCGETSSQIQDSIVTKNTLPGVGPCESS------MRGEKVMGHSSLNCYIRVGAGHKPH 131
            |......| :.||.:..||:| |..|...|.|.:      .|.|:|:..:|.:.:    |.....
  Fly   244 EGYQSMMC-DISSSLASSIIT-NHDPPPAPNEPNCLEMLQRRTEEVLDSASQSLH----AAQMQE 302

Human   132 EYHECGEKP-----DTHKQR----GKAFSYHNSFQTHERLHTGKKPYDCKECGKSFSSLGNL--- 184
            ||.|...|.     :..|.|    ||.|..:::.|.|.|.|||::|:.|..||..|::.|||
  Fly   303 EYSEYASKEAQSRGEIFKHRCKYCGKIFGSYSALQIHLRSHTGERPFVCNVCGSKFTTKGNLKVH 367

Human   185 -QRH------MAVQRGDGP--------------YKCKLCGKAFFWPSLLHMHERTHTG--EKPYE 226
             |||      |.:..|..|              |..:|.    |.|.:..:.:..|..  |:|.|
  Fly   368 YQRHTQIFPPMLLPPGVAPNVGHSGQGQVQGEQYPIRLP----FAPPVAPVGQEQHQNQVEEPEE 428

Human   227 CKQCSKAFSFYSSYLRHERTHTGEKPY-ECKQCSKAFPFYSSYLRHERTHTGEKPYKCKQCSK-- 288
            .:|                    |.|. :.:..||  |...   ..|::|:..:..|..:..|
  Fly   429 IRQ--------------------EIPVPQAEDLSK--PMVK---EKEKSHSPVERVKTPKEVKTD 468

Human   289 -AFPDSSSCLIHERTHTGEKPYTCKQCGKAFSVS----GSLQRHETT-----------------H 331
             |.|.|            |||.  |:..|....|    ||:::.:|:                 |
  Fly   469 AALPSS------------EKPE--KEISKPVVTSSRRNGSVRKRQTSAVSPPQEDRERDLVEHLH 519

Human   332 SAE---KPYACQQCGKAFHHLGSFQRHM-------------------------IRHTGNGPHKCK 368
            .|:   :..|.::...|.:.|...:|.:                         |.:....|::|.
  Fly   520 IAKLVRRSSASRESQPAEYSLAQMERIIDKSWEDLIEIDKTSETSKLQQLVDNIENKLTDPNQCI 584

Human   369 ICGKGFDCPSSLQSHERTHTGEKPYECKQCGKALSHRSSFRSHMIMHTGDGP----HKCKVCGKA 429
            .|.|...|.||||.|.||||||:|:.||.||:|.:.:.:.::||.:|....|    .||.||.:.
  Fly   585 FCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIHKIKPPMRSQFKCPVCHQK 649

Human   430 FVYPSVFQRHERTHT-----------AEKPYKCKQCG-------KAYRISSSL-----------R 465
            |....:.|:|.|.||           |..|.:.::.|       |:...|.:|           :
  Fly   650 FSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAERLGIEDQNSNKSLGTSDTLDFSTTISDHSGQ 714

Human   466 RHETTHTG----------------------------------EKPYKCKLGKACIDFCSFQNHKT 496
            |.|::..|                                  ||..:.::...|.|..|..|...
  Fly   715 RSESSQGGDFDEFMTMDSTDDSRDNSSAATATPHPLERERDREKERERRIPNDCSDERSHSNPDL 779

Human   497 T----HTGEKP---------------------------------------------------YEC 506
            |    .:||.|                                                   .|.
  Fly   780 TGGRSESGEMPAMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPMLGMPMPPNLLLMAAAREEM 844

Human   507 KECGKAFSRFRYLSRHKRTHTG--EKPYECKTCRKAFGHYDNLKVHERIHSGEKPY-------EC 562
            ...|.|.::|..|........|  ..|..|..|.|.......|:.|.:....::|.       :|
  Fly   845 HALGHAHAKFPLLPFGPLGFMGLHPPPNVCNLCFKMLPSLAALESHLQSEHAKEPATGHAQRPQC 909

Human   563 KECGKAF-SWLTCFLRHERIHMREKSYECPQCGKAFTHS---------------------RFLQG 605
            .:.|..: :.||  |.......:..|......|:....|                     ..|..
  Fly   910 SDAGSPYGAKLT--LNPNLFAKKPPSSSSSSSGEKLPESSNPPFPAENPPATPIKEDPDQEQLMV 972

Human   606 HEKTHTGE--------------------------------------------------------- 613
            .|....||
  Fly   973 EEGASAGEGSGTGATSNYPQEAGDAEQSLMKMQLHAHRFPASPLDFQQALMSAGPPTSSLDPPVN 1037

Human   614 NPYECKECGKAFASLSSLHRHKKTHWKKTHTGENPYECKECGKAFASLSSLHRHKKTH 671
            |.:.|..|.:.|:|.|:|..|     .:||||:.|::|..|.|||.:..:|..|..||
  Fly  1038 NKHFCHVCRRNFSSSSALQIH-----MRTHTGDKPFQCNVCQKAFTTKGNLKVHMGTH 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF443	NP_005806.3	KRAB	3..43	CDD:307490
		C2H2 Zn finger	133..163	CDD:275368	11/38 (29%)
		C2H2 Zn finger	171..191	CDD:275368	11/29 (38%)
		COG5048	196..579	CDD:227381	111/583 (19%)
		C2H2 Zn finger	199..219	CDD:275368	3/19 (16%)
		C2H2 Zn finger	227..247	CDD:275368	1/19 (5%)
		C2H2 Zn finger	255..275	CDD:275368	4/19 (21%)
		C2H2 Zn finger	283..303	CDD:275368	4/22 (18%)
		C2H2 Zn finger	311..331	CDD:275368	6/40 (15%)
		C2H2 Zn finger	339..359	CDD:275368	4/44 (9%)
		C2H2 Zn finger	367..387	CDD:275368	10/19 (53%)
		C2H2 Zn finger	395..415	CDD:275368	7/19 (37%)
		C2H2 Zn finger	423..443	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	6/37 (16%)
		C2H2 Zn finger	506..526	CDD:275368	4/19 (21%)
		C2H2 Zn finger	534..554	CDD:275368	5/19 (26%)
		C2H2 Zn finger	562..582	CDD:275368	5/20 (25%)
		C2H2 Zn finger	590..610	CDD:275368	4/40 (10%)
		C2H2 Zn finger	618..638	CDD:275368	7/19 (37%)
		C2H2 Zn finger	651..671	CDD:275368	7/19 (37%)
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	7/21 (33%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		zf-H2C2_2	335..360	CDD:290200	11/24 (46%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		C2H2 Zn finger	583..603	CDD:275368	10/19 (53%)
		zf-H2C2_2	595..620	CDD:290200	16/24 (67%)
		C2H2 Zn finger	611..631	CDD:275368	7/19 (37%)
		C2H2 Zn finger	643..663	CDD:275368	7/19 (37%)
		lambda-1	1013..>1061	CDD:212564	8/52 (15%)
		zf-C2H2	1040..1062	CDD:278523	7/26 (27%)
		C2H2 Zn finger	1042..1062	CDD:275368	7/24 (29%)
		zf-H2C2_2	1054..1079	CDD:290200	12/29 (41%)
		C2H2 Zn finger	1070..1090	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910