DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GPA33 and DIP-beta

DIOPT Version :9

Sequence 1:	NP_005805.1	Gene:	GPA33 / 10223	HGNCID:	4445	Length:	319	Species:	Homo sapiens
Sequence 2:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	380	Identity:	77/380 - (20%)
Similarity:	140/380 - (36%)	Gaps:	120/380 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    27 PQDVLRASQGKSVTLPCTYHT--------STSSREGLIQWDK-----LLLTHTERVVIWPFSNKN 78
            |.:.:..:||:..|..|..:.        ..||....:.|.|     :|..| |.|:    :|
  Fly   103 PLENVTIAQGRDATFTCVVNNLGGHRVSGDGSSAPAKVAWIKADAKAILAIH-EHVI----TN-- 160

Human    79 YIHGELYKNRVSISNNAEQSDASITIDQLTMADNGTYECSVSLMSDLEGNT----KSRVRLLVLV 139
                   .:|:|:.:| :.:..::.|..:.|.|.|.|.|.|        ||    .....|.|::
  Fly   161 -------NDRLSVQHN-DYNTWTLNIRGVKMEDAGKYMCQV--------NTDPMKMQTATLEVVI 209

Human   140 PPSKPECGIEGETII--GNNIQLTCQSKEGSPTPQYSWKRYN---IL----NQEQPLAQPASGQP 195
            ||........|:.::  |.:.:|.|::: |.|.|:.:|:|.:   |:    :.::..||...|:.
  Fly   210 PPDIINEETSGDMMVPEGGSAKLVCRAR-GHPKPKITWRREDGREIIARNGSHQKTKAQSVEGEM 273

Human   196 VSLKNISTDTSGYYICTSSN--------------------------------EEGTQFCNITVAV 228
            ::|..|:....|.|:|.:||                                .:.|..||:..:.
  Fly   274 LTLSKITRSEMGAYMCIASNGVPPTVSKRMKLQVHFHPLVQVPNQLVGAPVLTDVTLICNVEASP 338

Human   229 RSPSM----NVALYVGIAVGVVAAL-------IIIGIII------------YCCCCRGKDDNTED 270
            ::.:.    |..:   |..|...||       ..|.:|:            |.|..:....:||.
  Fly   339 KAINYWQRENGEM---IIAGDRYALTEKENNMYAIEMILHIKRLQSSDFGGYKCISKNSIGDTEG 400

Human   271 K----EDARPNREAYEEPPEQLRELSREREEEDDYRQEE--QRSTGR----ESPD 315
            .    |..||.::...:  :.|.|:|:....:.|.|.|:  :...||    .:||
  Fly   401 TIRLYEMERPGKKILRD--DDLNEVSKNEVVQKDTRSEDGSRNLNGRLYKDRAPD 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPA33	NP_005805.1	V-set	26..138	CDD:311561	27/127 (21%)
		IGc2	154..218	CDD:197706	19/104 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..319		15/59 (25%)
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	28/128 (22%)
		ig	102..195	CDD:278476	24/114 (21%)
		IG_like	219..307	CDD:214653	20/88 (23%)
		Ig	221..307	CDD:299845	19/86 (22%)
		Ig	311..404	CDD:299845	14/95 (15%)
		IG_like	327..405	CDD:214653	14/80 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910