Protein Alignment TRIB1 and SNF1

DIOPT Version :10

• Sequence 1: NP_079471.1
• Gene: TRIB1 / 10221
• HGNCID: 16891
• Length: 372
• Species: Homo sapiens
• Sequence 2: NP_010765.3
• Gene: SNF1 / 852088
• SGDID: S000002885
• Length: 633
• Species: Saccharomyces cerevisiae
• Alignment Length: 308
• Identity: 89/308 - (28%)
• Similarity: 149/308 - (48%)
• Gaps: 28/308 - (9%)

Human    77 GAGGGSGSAPGP-SRIAD-------YLLLPLAEREHVSRALCIH--TGRELRCKVFPIK-----H 126
            |.||.:.:...| |.:||       .::..|.|.......|..|  ||:::..|:...|     .
Yeast    31 GHGGSNSTLNNPKSSLADGAHIGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSD 95

Human   127 YQDKIR---PYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQ 188
            .|.:|.   .|::|..|.:|..:.:||..:.:..:..|....::..|:..|.::.|:||.|.|:|
Yeast    96 MQGRIEREISYLRLLRHPHIIKLYDVIKSKDEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQ 160

Human   189 IVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEI 253
            |:|||.:||:..||..|||....:.  :|...:::.....::||. :.:.|....|.|.|.:||:
Yeast   161 IISAVEYCHRHKIVHRDLKPENLLL--DEHLNVKIADFGLSNIMT-DGNFLKTSCGSPNYAAPEV 222

Human   254 LNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSL 318
            ::.. .|:|...||||.||:||.:|..|.||.|.....||..|..|.:.:|:.:||.|..||:.:
Yeast   223 ISGK-LYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIKRM 286

Human   319 LRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPEYQEDSD 366
            |...|..|::..||:...||:..| |.|:     ....:.|..:|:::
Yeast   287 LIVNPLNRISIHEIMQDDWFKVDL-PEYL-----LPPDLKPHPEEENE 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRIB1	NP_079471.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	52..86		3/8 (38%)
		PK_TRB1	97..338	CDD:270925	75/250 (30%)
		COP1-binding. /evidence=ECO:0000250|UniProtKB:Q8K4K4	355..360		0/4 (0%)
SNF1	NP_010765.3	STKc_AMPK_alpha	52..306	CDD:270981	75/257 (29%)
		UBA_2	344..389	CDD:430091
		AdenylateSensor	504..626	CDD:406881