Protein Alignment TRIB1 and KCC4

DIOPT Version :10

• Sequence 1: NP_079471.1
• Gene: TRIB1 / 10221
• HGNCID: 16891
• Length: 372
• Species: Homo sapiens
• Sequence 2: NP_009907.2
• Gene: KCC4 / 850334
• SGDID: S000000529
• Length: 1037
• Species: Saccharomyces cerevisiae
• Alignment Length: 287
• Identity: 82/287 - (28%)
• Similarity: 129/287 - (44%)
• Gaps: 53/287 - (18%)

Human    84 SAPGPSRIADYL------LLPLAEREHVSRALCIHTGRELRCKVFPIKHY--------QDKIRPY 134
            |..||.::.:.|      .:.||:.|        .||.....||.....:        .|.:.||
Yeast    16 STIGPWKLGETLGFGSTGKVQLAQHE--------RTGHRTAVKVISKSIFNNNGNHSNDDSVLPY 72

Human   135 --------IQLPSHSNITGIVEVILGETKAYVFFE-KDFGDMHSYVRSRKRLREEEAARLFKQIV 190
                    ::|.||.|:..:.:|.......|:..| .:.|::.:.:.....|.|.||...|:||:
Yeast    73 NIEREIVIMKLLSHPNVLSLYDVWETNNNLYLILEYAEKGELFNLLVDHGPLPEREAINCFRQII 137

Human   191 SAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHI-------MKGEDDALSDKHGCPAY 248
            ..:::||...||..|||          ...|.|:|..:..|       ::.:.|.|....|.|.|
Yeast   138 IGISYCHALGIVHRDLK----------PENLLLDSFYNIKIADFGMAALQTDADLLETSCGSPHY 192

Human   249 VSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSA--LFSKIRRGQFCIPE--HISP 309
            .:|||::.. .|.|.|:||||.||:|:.||.||.||.:.:.:.  |..|:::|||.:|.  .||.
Yeast   193 AAPEIVSGL-PYEGFASDVWSCGVILFALLTGRLPFDEENGNVRDLLLKVQKGQFEMPNDTEISR 256

Human   310 KARCLIRSLLRREPSERLTAPEILLHP 336
            .|:.||..:|..:|.:|:...:||.||
Yeast   257 DAQDLIGKILVVDPRQRIKIRDILSHP 283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRIB1	NP_079471.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	52..86		1/1 (100%)
		PK_TRB1	97..338	CDD:270925	78/268 (29%)
		COP1-binding. /evidence=ECO:0000250|UniProtKB:Q8K4K4	355..360
KCC4	NP_009907.2	Protein Kinases, catalytic domain	19..285	CDD:473864	81/284 (29%)
		Kcc4p_like_C	920..1034	CDD:213379