Protein Alignment TRIB1 and nipi-3

DIOPT Version :10

• Sequence 1: NP_079471.1
• Gene: TRIB1 / 10221
• HGNCID: 16891
• Length: 372
• Species: Homo sapiens
• Sequence 2: NP_510573.3
• Gene: nipi-3 / 181650
• WormBaseID: WBGene00010700
• Length: 655
• Species: Caenorhabditis elegans
• Alignment Length: 250
• Identity: 64/250 - (25%)
• Similarity: 117/250 - (46%)
• Gaps: 23/250 - (9%)

Human   105 VSRALCIHTGRELRCKVFP---IKHYQDKIRPYIQLP-------------SHSNITGIVEVILGE 153
            |:||:|..|.......|.|   .....|.|| .:|:|             |...|:..:|:|...
 Worm   211 VTRAVCSQTREMFTAHVLPEWKASKVIDVIR-RLQIPTDISSMTADEIRLSELCISKRMEIIKSN 274

Human   154 TKAYVFFEKDFGDMHSYVRSR-KRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEE 217
            .:..:....:...:|||...| ..:.|.:...:::::|..|..||...::|.:.|.|.|....:.
 Worm   275 DRYILMNPCESATIHSYATERLDEITENDVMSIYQKVVEIVRFCHSRKVILQNFKPRSFYLKKDA 339

Human   218 RTQ--LRLESLEDTHIMKGEDDA-LSDKHGCPAYVSPEILNT-TGTYSGKAADVWSLGVMLYTLL 278
            ..:  :|...|:|....:.:.:| .:.:..|..:::||:|.. :.|:...:.::|.|||:||.||
 Worm   340 HNKWVVRPCFLQDMSCEEDQSEAQFTRRSVCVPFMAPEMLTAESRTHHSYSTELWGLGVLLYILL 404

Human   279 VGRYPFHDSDPSALFSKIRRGQFCIP-EHISPKARCLIRSLLRREPSERLTAPEI 332
            .|:||||::....||..|:..|...| ..||.|:|.::..||::.|:.|:...::
 Worm   405 TGKYPFHENSMPLLFRTIKFKQHRWPFNFISSKSRNIVNMLLKKAPATRMNLEDL 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRIB1	NP_079471.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	52..86
		PK_TRB1	97..338	CDD:270925	64/249 (26%)
		COP1-binding. /evidence=ECO:0000250|UniProtKB:Q8K4K4	355..360
nipi-3	NP_510573.3	Protein Kinases, catalytic domain	208..459	CDD:473864	64/248 (26%)