Protein Alignment GDF11 and scw

DIOPT Version :10

• Sequence 1: NP_005802.1
• Gene: GDF11 / 10220
• HGNCID: 4216
• Length: 407
• Species: Homo sapiens
• Sequence 2: NP_524863.3
• Gene: scw / 46000
• FlyBaseID: FBgn0005590
• Length: 400
• Species: Drosophila melanogaster
• Alignment Length: 370
• Identity: 86/370 - (23%)
• Similarity: 136/370 - (36%)
• Gaps: 74/370 - (20%)

Human    88 RLKEAPNISREVVKQLLPKAPPLQQILD----LHDFQGDALQPEDFL---EEDEYHATTETVISM 145
            |.:..||:.....|.||.....:.:..:    ||.....:|. :|.|   |:.:..|:..::::.
  Fly    53 RRQAEPNLHNSASKFLLEVYNEISEDQEPKEVLHQRHKRSLD-DDILISNEDRQEIASCNSILTF 116

Human   146 AQETDPAVQTDGSPLCCHFHFSPK--VMFTKVLKAQLWVYLRP--VPRPATVYLQILRLKPLTGE 206
            :....|. |.| :.|..|..|:..  .:...:::|.|.:|.:|  |.|.|...:.:.|..
  Fly   117 SSRLKPE-QLD-NELDMHITFNTNDVPVDLSLVQAMLRIYKQPSLVDRRANFTVSVYRKL----- 174

Human   207 GTAGGGGGGRRHIRIRSL-KIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIE------INAFDP 264
                   ..|:....|.| .:...|....|...:....|..|..    |.|::      |:..|.
  Fly   175 -------DNRQDFSYRILGSVNTTSSQRGWLEFNLTDTLRYWLH----NKGLQRRNELRISIGDS 228

Human   265 SGTDLAV---------TSLGP-------GAEGLHPFMELRVLENTKRSRRNLGL-------DCDE 306
            ..:..|.         |||.|       |.|.|....:||...:.::.|...|.       ..|.
  Fly   229 QLSTFAAGLVTPQASRTSLEPFIVGYFNGPELLVKIQKLRFKRDLEKRRAGGGSPPPPPPPPVDL 293

Human   307 HSSESRCCRYPLTVDF-EAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHT---------HLVQQ 361
            :.....|.|...|||| |....:|:||||:::|.:|.|.|.:....|...|         ||.|.
  Fly   294 YRPPQSCERLNFTVDFKELHMHNWVIAPKKFEAYFCGGGCNFPLGTKMNATNHAIVQTLMHLKQP 358

Human   362 ANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406
            ..|:    |||.||.:..|.:|.:.::..|...|....|...|||
  Fly   359 HLPK----PCCVPTVLGAITILRYLNEDIIDLTKYQKAVAKECGC 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GDF11	NP_005802.1	TGFb_propeptide	61..285	CDD:480997	46/230 (20%)
		TGF_beta_GDF8	301..407	CDD:381658	37/123 (30%)
scw	NP_524863.3	TGFb_propeptide	39..254	CDD:480997	43/219 (20%)
		TGF_beta_BMP5_like	299..400	CDD:381639	35/105 (33%)