Protein Alignment GDF11 and Actbeta

DIOPT Version :10

• Sequence 1: NP_005802.1
• Gene: GDF11 / 10220
• HGNCID: 4216
• Length: 407
• Species: Homo sapiens
• Sequence 2: NP_651942.2
• Gene: Actbeta / 43826
• FlyBaseID: FBgn0024913
• Length: 946
• Species: Drosophila melanogaster
• Alignment Length: 617
• Identity: 121/617 - (19%)
• Similarity: 182/617 - (29%)
• Gaps: 281/617 - (45%)

Human    46 ERSSRPAPSVAPEPDGCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPL 110
            :::::|..::||             |.|:||||||.|||:||.|...||:|..:.||.:.:.
  Fly   354 KKTNQPHNNIAP-------------SDEVRLESIKRQILTKLGLSHKPNVSHPLPKQFIWET--- 402

Human   111 QQILDLHDFQGDALQPEDFLEEDEYHATTETV-------------------ISMAQETDPAVQTD 156
                 ::...|..:.|.:.......:...:|:                   .....|.||:....
  Fly   403 -----IYRVDGGRMIPNNAFGSSGKNLDQKTIKLRAFASPGSHLFNGRGGRTDQRSERDPSHHKY 462

Human   157 GSPLCCHFHFSPKVMFTKVLKAQL-------------WVYLRPVPRPATVYLQILRLK------- 201
            .||....|:.|...::.|||:.:.             |...|.:...:.:....:.||
  Fly   463 RSPFDFTFNISKNNVYGKVLRNRSLERIDKKNSFLNGWTENRQLKINSQIASMPIELKSHHNSSP 527

Human   202 -----------------------------PL-----TGEGTAGGGGG------------------ 214
                                         |:     ....|..|..|
  Fly   528 KELKSGAVRKVNGINGTQMNENALKKSTYPIDINHSIDNKTHTGKNGEMSHNDYEYFNDYSVQTH 592

Human   215 -------GRRHIRIRSL--KIELHSRSGHWQSI----------DF----KQVL------------ 244
                   ||..|..:..  .||..::.||.:|.          ||    ::::
  Fly   593 DKNRYHEGRSSIGYQPAIHNIEYENQKGHHESFADDHENIDHEDFFGNTQEIITFAEEGTQYRQY 657

Human   245 -------------------------------HS-WFRQPQS-----------NWG-------IEI 259
                                           || |..:.:|           .||       |:|
  Fly   658 RILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKI 722

Human   260 NAFDPS--------GTDLAV------------------------------------------TSL 274
            ..|..|        |.|.|:                                          |..
  Fly   723 WVFQLSTSINITEKGIDKAIIFRASFQVDPKNLGWQKFDLTDTIREWYGHTSHEKLRLLIDCTGC 787

Human   275 GPGAEGLH---------------------PFMELRVLENTKRSRRNLGLDCDEHSSESRCCRYPL 318
            | |...||                     ||:.|....:..|..|...:||. .:...:||:...
  Fly   788 G-GRYSLHLFQTSKLRGNSSDYLSTNPNRPFLVLHTESSRTRRVRRRAVDCG-GALNGQCCKESF 850

Human   319 TVDFEAFGW-DWIIAPKRYKANYCSGQCEYMF-----MQKYPHTHLVQQANPRG---SAGPCCTP 374
            .|.|:|.|| ||||||:.|.||||.|.|...|     .|.: |.|.:::....|   ...|||.|
  Fly   851 YVSFKALGWDDWIIAPRGYFANYCRGDCTGSFRTPDTFQTF-HAHFIEEYRKMGLMNGMRPCCAP 914

Human   375 TKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406
            .|.|.::::|:.| ..||...:|.||||.|||
  Fly   915 IKFSSMSLIYYGD-DGIIKRDLPKMVVDECGC 945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GDF11	NP_005802.1	TGFb_propeptide	61..285	CDD:480997	69/470 (15%)
		TGF_beta_GDF8	301..407	CDD:381658	45/115 (39%)
Actbeta	NP_651942.2	TGF_beta_INHB	845..945	CDD:381630	41/101 (41%)